Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"Immune priming"”.
-
Immune Priming in A. Mellifera
Trans-generational immune priming (TgIP) is the transfer of maternal immune experience to progeny, producing offspring pathogen resistance and ultimately survival from infections. In colony-forming insects like the honey bee Apis mellifera, TgIP would yield a form of lasting immunity benefiting …
-
Understanding immune priming in Pacific oysters: A multi-omics exploration of transcriptomic, epigenetic and microbiome regulation
… to prevent or to treat and, in this context, immune priming has been proposed as a method to increase resistance to disease, and has been reported to be effective for viral pathogens. However, it is unknown whether an immune response can be primed in oysters to provide protection against …
-
Understanding immune priming in Pacific oysters: A multi-omics exploration of transcriptomic, epigenetic and microbiome regulation
… to prevent or to treat and, in this context, immune priming has been proposed as a method to increase resistance to disease, and has been reported to be effective for viral pathogens. However, it is unknown whether an immune response can be primed in oysters to provide protection against …
-
Atr-Mediated Cd47 and Pd-L1 Upregulation Restricts Radiotherapy-Induced Immune Priming and Abscopal Responses In Colorectal Cancer
… are extremely rare, and the post-irradiation immune escape mechanisms in CRC remain elusive. We report that CRC cells utilize a common DNA repair signaling pathway — ATR/Chk1/STAT3 — to upregulate both CD47 and PD-L1 in response to radiotherapy, which through engagement of SIRPα and PD-1 …
-
Leveraging Innate Immune Sensors to Generate Durable Anti-Glioma Adaptive Immune Responses
… T cell effector infiltration but is dominated by immune suppressive microglia, macrophages, and myeloid-derived suppresser cells. These innate immune cells display impaired phagocytosis and antigen presentation and are inadequate for triggering the subsequent immune activating signals needed for …
-
Identifying Immunological Signatures in Blood Predictive of Host Response to Plasmodium Falciparum Vaccines and Infections Using Computational Methods
… Plasmodium parasites that cause malaria and host immune system have made it difficult to identify specific mechanisms of vaccine-induced and naturally acquired immunity. After more than half a century of research into potential immunization methods, reliable immune correlates of malaria protection …
-
Impact Of Cryoablation On Tumor Immunity
… an effective tool for both tumor debulking and immune priming if Th1-promoting adjuvants are used in combination therapy.</p>
-
An analysis of the cellular and humoral immune responses of Galleria mellonella larvae
The invertebrate immune system is composed of the intertwined cellular and humoral components which have similar structural and functional attributes to the mammalian innate immune system. For this reason insects have served as useful screening tools in academic and industry research for the …
-
The Gut Mucosal Microbiome of HIV- exposed Uninfected Infants in Africa
… Uninfected (HUU) peers, as well as altered immune and vaccine responses. The reasons for this remain unclear, but one hypothesis is that altered gut microbiomes in HEU adversely affect the developing infant immune system. The microbiome (a collection of an array of microorganisms, their …
-
Characterization of virulence-attenuated Listeria monocytogenes common among food and food-associated environments but rarely associated with disease
… (i) raise listeria-specific CD8+ T cell-mediated immune responses and (ii) confer protection against a subsequent challenge by a fully-virulent strain. Results provided evidence that after exposure to L. monocytogenes carrying a VA SNP in inlA, there is an expansion of Listeria-specific CD8+ T …
-
The Impact of Heat Stress on Immune Function
… entire ecosystems, the impact of heat stress on immune competence remains poorly understood. Indeed, both protective and detrimental consequences to immune function have been assigned to heat, including in the context of infection. This thesis combines in vivo models, flow cytometry and …
-
A computational approach to understanding maternal influences on the development of ruminant neonates
… transfer of maternal immunoglobulins (IgGs) and immune cells. This vulnerability is further exacerbated by overlapping early-life health challenges, including metabolic, microbial, mucosal, and mental stress. Additionally, ruminant newborns possess limited energy and nutrient reserves within …