Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Immune modulators"”.
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Development of Immune Modulators Targeting Autoimmune Disorders and Pulmonary Injury: Design, Synthesis, and Biological Evaluation of Sphingolipid-Derived Sphingosine-1 Phosphate Receptor 1 Agonists
… and asthma account to the most prevalent autoimmune diseases and pose major challenges in modern medicine. The lysophospholipid–activated G protein–coupled receptor family of sphingosine-1-phosphate receptors are central regulators of the eukaryotic native as well as adaptive immune system and …
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The Design and Synthesis of Novel Barbiturates of Pharmaceutical Interest
… that barbituric acid derivatives may also act as immune modulators. The recent explorations of barbiturates and their potential anti-cancer and immune modulating properties are the subject of this work. Novel synthetic approaches to the development of new barbituric acid derivatives were explored …
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Multi-omic Approaches to Investigate the Inflammatory Response in Activated Macrophage Cells
… stimuli. Cells were treated with immune modulators that either<br/>modelled bacterial infection (Kdo2-Lipid A) or reflected the signals produced by<br/>damaged or dying cells during clearance (ATP). In-depth proteomic analyses<br/>identified significant metabolic reprogramming …
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The Evolution of Drosophila Immunity
… conditions alike. However, the divergence of immune response is overwhelmingly driven by trans, suggesting that altering trans-regulatory elements, such as signalling pathways or immune modulators, may allow natural selection to alter the expression of large numbers of immune-responsive genes …
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Novel immunotherapy for paediatric cancers
… heterogeneity in the expression of multiple immune co-signalling ligands by leukaemia cells derived from individual patients. High CD86, CD70 and ICOSL was associated with bad CART cell persistence while OX40L and IL10 expression - with good CART cell persistence and delayed CART cell …
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The role of tissue-resident immune cells in PanIN to PDAC progression
… lymphoid cells (ILC2) are emerging as important immune modulators of the cancer microenvironment, although their role in PDAC remains contentious with both pro- and anti-cancer roles having been described. In this thesis, I have characterised the role of ILC2 in early- and late-stage PDAC with …
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The Novel Function of Creatinine Acting as an Anti-Inflammatory Immunomodulator and Antioxidant
… these data suggest that both CR and CRN act as immune modulators by inhibiting pro-inflammatory cytokine TNF-α, and it has been hypothesized that CR supplementation may decrease the ability of the host to respond rapidly to pathogens due to increased CRN levels. Furthermore, the data suggest …
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The impact of HIV-1 subtype C Envelope N-glycosylation on DC-SIGN meditated modulation of DC function to facilitate transmission or enhance viral pathogenesis
… and may be involved in the modulation of the immune response to HIV-1 infection. In this study, we hypothesized that Env N-glycosylation may affect viral pathogenesis by influencing Env structure and function. Furthermore, we also postulated that differences in Env glycosylation could affect …