Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Immune modulator"”.
-
Mild Traumatic Brain Injury with Associated Visual System Dysfunction: Investigating Histopathology, Functional Correlates, and a Novel Therapeutic Immune Modulator
… of the brain’s reaction to trauma is an immune response that can cause additional long-term damage above and beyond that of the initial injury. This response was observed in our model as regions of microglial cell activation throughout areas of the brain important for visual processing. A …
-
De novo design of protein binders as functional therapeutics
… I report the design of minibinder antagonists as immune modulator for cytokine storm; in Chapter 3, I report the design of endocytosis ligands for target degradation and signaling amplification. Overall, the minibinder is a brand-new drug modality/platform with advantages of ultra-stability, …
-
Development and Characterization of B7-H3-Targeted Radioimmunotherapies For The Treatment of Solid Tumors
… a treatment for solid tumors and as a potential immune modulator.</p>
-
Understanding the function and structure of herpes simplex virus type 1 pUL55, a novel immune evasion protein
… protein, which we hypothesised to be an innate immune modulator with similar functions to ICP0. ICP0 exhibits E3 ubiquitin ligase activity and is known to stimulate proteasomal degradation of several host proteins in HSV-1 infected cells. Multiple studies to date have used the *dl*1403 mutant …
-
Gene Therapy and Stem Cell Therapy to Improve the Outcome of Human Islet Transplantation
… is hindered by two major barriers, the immune rejection from the organ recipients and the PNF of islet grafts. Immune rejection describes a process where transplanted islets are attached, recognized and attacked by the host immune system while the PNF is characterized as the loss of …
-
Studying the B and plasma cell responses to the immune checkpoint blockade treatment of cancer
Immune checkpoint blockade (ICB) therapies targeting PD-1 and CTLA-4 have revolutionised cancer treatment. However, their efficacy is not completely understood, especially regarding their effects on anti-tumour B and plasma cell responses, which are now regarded as important components of the …