Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"Immune microenvironment"”.
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Modulating Tumor Immune Microenvironment Using Heterologous Proteins
… response rates among different cancers. Since, immune cells and the cancer cells share the same genetic background, tumor cells evolve to evade anti-tumor immune responses by either hijacking the pathways already present in the body to avoid overactivation of immune responses or creating a …
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Modulating Tumor Immune Microenvironment Using Heterologous Proteins
… response rates among different cancers. Since, immune cells and the cancer cells share the same genetic background, tumor cells evolve to evade anti-tumor immune responses by either hijacking the pathways already present in the body to avoid overactivation of immune responses or creating a …
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Computational profiling of the tumour immune microenvironment
… cancer cells but other populations, including immune and stroma, collectively termed the tumour microenvironment (TME). Single-cell RNA sequencing has offered unparalleled insights in different and rare cell populations. However, bulk RNA-seq remains a cost-effective and widely-used approach to …
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The Immune Microenvironment of Microsatellite Instable Endometrial Cancer
… benefit from these therapies; however, the tumor immune microenvironment in MSI-H EC has not yet been well described.</p> <p>In order to evaluate the immune microenvironment of MSI-H EC, multiple approaches were used, including analysis of large publically available datasets and detailed …
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Investigation of Divergent Metabolic Programs in the Tumor-Immune Microenvironment
The current immune metabolism field has been using the term lactate and lactic acid interchangeably, with the notion that lactate and lactic acid are waste products of highly glycolytic cancer cells that negatively affects TIL function and viability to promote tumorigenesis. However, it is yet …
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Decoding The Tumor and Immune Microenvironment In Pdac and Breast Cancer By Single Cell Sequencing.
… populations and gene changes for the purpose of immune-related cancer therapies. First we have characterized the T cell populations of the normal and malignant human pancreas. Furthermore, we utilized single cell TCR sequencing to track transcriptional states of T cell clones from human PDACs …
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Unraveling Epigenetic Mechanisms That Regulate Breast Cancer Lung Metastatic Relapse by Rewiring the Immune Microenvironment
… transcription factor sites with key roles in immune cell lineages.</p> <p>Luminex cytokine profiling also revealed to us that loss-of-Brd7 led to upregulation of pro-metastatic cytokine secretion like CXCL10, CCL5, CCL2, CCL20. To further delineate the effect of loss-of-Brd7 on the immune …
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TimiGP: A Computational Framework to Determine the Tumor Immune Microenvironment Associated with Prognosis and Immunotherapy Response
… evidence has suggested that the tumor immune microenvironment (TIME) drastically impacts cancer patients’ clinical outcomes, including prognosis and immunotherapy response. However, understanding TIME remains challenging due to its complexity and heterogeneity. In this dissertation, we …
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Role of STAT1 in Disease Progression and the Tumour Immune Microenvironment of High-Grade Serous Ovarian Cancer
… Recent studies investigating the tumour immune microenvironment have highlighted the prognostic significance of different tumour infiltrating lymphocyte (TIL) subsets and secreted immune factors in HGSC. However, the mechanisms promoting TIL recruitment to the tumour epithelial …
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The role of B lymphocytes, plasma cells and tertiary lymphoid structures in the immune microenvironment of Non-Small Cell Lung Cancer
… όπως οι αναστολείς ανοσιακών σημείων ελέγχου (immune checkpoint inhibitors, ICIs). Οι TLS διευκολύνουν την προσέλκυση και την ενεργοποίηση των Τ και Β λεμφοκυττάρων εντός του μικροπεριβάλλοντος του όγκου, οδηγώντας σε ισχυρότερες προσαρμοστικές ανοσιακές αποκρίσεις, οι οποίες χαρακτηρίζονται …
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Dissecting the Relationship between Mucin 5AC and the Lung/Gut Microbiome in the Pathogenesis of K-ras Mutant Lung Cancer
… of mucin polymers on bacterial growth and the immune microenvironment in the context of other airway inflammatory diseases, this work aims to better understand the MUC5AC-to-microbiome relationship and test the combinatorial effects of MUC5AC-deficiency and pan-microbiome depletion on tumor …
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Assessing the temporal role of miR-200 loss in murine models of NSCLC
… by epithelial-mesenchymal transition (EMT) and immune evasion. The microRNA 200 family is a master regulator of EMT and is implicated in immune regulation. In this study we have developed a novel genetically engineered mouse model (GEMM) and derived primary cell lines from them to explore the …
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The Functional Contribution of Adaptive Immunity In The Biology of Pancreatic Cancer and Therapeutic Targeting of Oncogenic Kras
… technique and new combination chemotherapies. Immune checkpoint blockade has revolutionized the treatment of cancers such as melanoma, bladder cancer and non-small cell lung carcinomas. Unfortunately, PDAC is among the tumor types that remain refractory to checkpoint immunotherapy(Royal et al., …
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Clonal Phenotype Mapping Reveals Genomic Alterations Underlying Tumor Immunosuppression during Immunotherapy
… shaping their ability to either elicit or evade immune responses. In pancreatic ductal adenocarcinoma (PDAC), where immunotherapy has yet to become an effective treatment option, we investigated the role of intratumoral heterogeneity in influencing immune interactions. Using orthotopic clonal …
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Clinical Relevance of the Immune Contexture and AXL Kinase in Triple-Negative Breast Cancer
… transition (EMT), and cancer-related immune responses. In particular, the tumour immune microenvironment and the interaction between immune and cancer cells are emerging as crucial factors in tumour progression, prognosis, and response to therapy in TNBC. In this study, we aimed to …
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Delineating metastasis in MSS colorectal cancer by single - cell RNA sequencing
… revealed significant heterogeneity in the tumor microenvironment (TME) characterized by a diversity of cancer-associated fibroblasts, immune cells, and endothelial cell populations. Notably, we identified different CAF subtypes, including inflammatory (iCAFs), matrix(mCAFs), complement (cCAFs), …
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Coordinated Blockade of TGF-β and PD-L1 Promotes Anti-Tumor Immunity in Ovarian Cancer Models
… diagnosis and high recurrence rates. Current immune checkpoint blockade (ICB) therapies show limited efficacy in HGSC, with no approved immunotherapy options for patients. This is due to an immunosuppressive tumor immune microenvironment (TIME) that limits the efficacy of ICB. Resistance to …
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Micrornas Associated With Melanoma Inflammation and Response to Pd-1 Inhibition
… molecularly targeted agents and immunotherapies. Immune checkpoint inhibitors achieve T-cell mediated anti-tumor efficacy by blocking engagement of inhibitory checkpoints on T-cells to overcome immunosuppressive signals from tumor cells and the broader microenvironment. Despite these advances, …
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Clinical Relevance of Immune Cells in Pancreatic Adenocarcinoma and their Implication in Immunotherapy
… have done during my PhD training, focused on the immune microenvironment of pancreatic adenocarcinoma (PDAC). The aim was to delineate key features of immunologic and tumour components shaping the biology of pancreatic cancer. Immunotherapy has been largely explored as a promising anticancer …
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