Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 26 for “"Immune effector"”.
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Engineering aglycosylated antibody variants with immune effector functions
… efficacy, the engagement and activation of immune effector cells - mediated by the interaction of the conserved Fc regions of the antibody with the Fc gamma receptors (Fc[gamma]Rs) on immune cells - is critical to the efficacy of several. This thesis describes the engineering of antibody Fc …
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The dynamics of anti-tumour responses generated by chimeric antigen receptor-modified immune effector cells
… tumours. Understanding the biology of CART cell effector function may explain treatment failure, and lead to more effective cell therapy products. Population-based assays such as flow cytometry give a snapshot of these complex cellular systems, but do not allow one to study the fate of individual …
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PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, ATHEROSCLEROSIS AND EXTRACELLULAR VESICLES ¿ EXPERIMENTAL AND CLINICAL EVIDENCE
… and secreted proteins involved in immune response and immune effector processes. Concerning macrophages, VSMCPCSK9-EVs enhanced inflammatory milieu and uptake of oxidized low-density lipoproteins, whereas the migratory capacity was reduced. When injected into zebrafish embryos, …
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HER2 and Folate Receptor Targeted Therapy is Enhanced by NK Cell-Activating Cytokines
… monoclonal antibodies (mAb) may depend on immune effector cells that express Fc receptors (FcR) for immunoglobulin G. Natural killer (NK) cells are innate immune effector cells that play a crucial role in cancer rejection and immunosurveillance. Importantly NK cells express the Fcgamma …
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Role of ICAM-1, a cell adhesion molecule, in morphological changes of BV2 microglial cell
Microglial cells, the major immune effector cells in the central nervous system, are activated in various brain injuries. Lipopolysaccharide (LPS), found in the outer membrane of Gram-negative bacteria, one of the major activator of microglia induces morphological changes and activation of the …
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Genetic analysis of endoplasmic reticulum homeostasis during stress and infection of Caenorhabditis elegans
… aeruginosa induces a transcriptional innate immune response leading to the secretion of immune effector molecules into the intestinal lumen. Previous work has demonstrated a critical role for the endoplasmic reticulum unfolded protein response in surviving immune activation during larval …
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Paclitaxel-induced macrophage activities in the tumor-bearing host: immunologic implications and therapeutic applications
Tumors induce immune dysfunction through the production of soluble factors that subvert macrophage (Mf) function to favor tumor growth. Previous studies suggested that tumor-induced immune cell dysfunction may be reversible through regimens that disrupt tumor cell suppressor mechanisms and …
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EXPLORING THE MUTATIONAL LANDSCAPE OF MITOCHONDRIAL GENOME IN HEMATOLOGIC MALIGNANCIES
… mtDNA mutations in non-neoplastic immune effector cells, suggesting potential implications for immune surveillance. Together, these findings provide the first systematic characterization of mtDNA alterations across major hematologic malignancies. They highlight the widespread …
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Impact of cationic host defence peptide LL-37 on human neutrophil death and inflammatory responses
… data on LL-37- mediated modulation of innate immune effector cell cytokines responses to inflammatory signals. I propose that during acute inflammation LL-37 can modulate innate immune responses through its activity on cytokine production, and that LL-37-mediated secondary necrosis of …
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Glioblastoma: multifaceted immunosuppression mediated through galectin family members
… describe the distribution of intratumoural immune cells, and characterise the effects of secreted immunomodulatory on adaptive immune effector cells. Mass spectrometry data identified galectin family members in the glioblastoma secretome. ELISA assays confirmed galectin presence in …
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Expression of ICAM-1, MHC-1 and B7 surface molecules in canine primary appendicular osteosarcoma
… it has developed mechanisms to elude the immune surveillance system. The aim of the study was to determine whether canine primary appendicular osteosarcomas express ICAM-1, MHC-1 and B7 molecules which are critical in eliciting optimum immune response. Cell lines and tissue sections …
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The pathogenesis of EHV1 in horses : novel insights from experimental inoculations and field situations
… how individual EHV1-infected cells escape from immune effector mechanisms at the primary site of replication (Chapter IV). Secondly, to develop suitable vaccination and treatment strategies during natural occurring outbreaks of disease, field information about the epidemiology of the virus is …
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PEDOT:PSS Enhanced Electroporation for Cell Therapy Manufacturing
… cellular systems to simultaneously optimize immune cell trafficking to the tumor microenvironment (TME), TME control, tumor recognition, healthy tissue discrimination, proliferation, persistence, and external feedback control. The typical production of these therapies incorporates various …
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Importance of specific NK cell subsets for antitumor immunity in HPV+ cancers
… (SOC) treatment. Identifying the antitumor host immune mediators important for treatment response and designing strategies to promote them are essential for improving clinical outcome. The natural killer (NK) cells are a critical component for antitumor innate effector immunity. Among the …
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Investigating functions of tumor-infiltrating natural killer cells in genetically-engineered mouse models of non-small cell lung cancer
The immune system has long been hypothesized to play a role in restraining tumor growth, but compelling evidence for this role evaded scientists for the better part of a century. After many years of skepticism, the field of cancer immunology has recently undergone a major revolution. The success of …
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Differential gene expression and immune regulatory mechanisms in parasite-resistant hair and susceptible wool sheep infected with the parasitic nematode, Haemonchus contortus
… objective was to determine differences in the immune response associated with parasite-resistant hair and susceptible wool lambs infected with 10,000 H. contortus and in uninfected controls. Animals were sacrificed and abomasum and lymph node tissues were collected at 3 or 27 days …
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The Treatment of Solid Tumours with Complete Freund's Adjuvant
… is an emerging field in cancer treatment. The immune system contains multiple immune cell types which have been demonstrated to play complex roles in cancer development, progression, and elimination of tumour masses. This thesis describes the assessment of a novel potential cancer treatment, …
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The Treatment of Solid Tumours with Complete Freund's Adjuvant
… is an emerging field in cancer treatment. The immune system contains multiple immune cell types which have been demonstrated to play complex roles in cancer development, progression, and elimination of tumour masses. This thesis describes the assessment of a novel potential cancer treatment, …
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Antibody-Effector Functions in Antiviral Response
… fundamental component of the adaptive arm of the immune system. Interactions of the antibody's fragment crystallizable (Fc) domain with Fc receptors (FcR) on effector leukocytes is essential for proper immunological function and bridges the humoral with the cellular components of immunity. While …
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Humoral immune response to melanoma: discovery and evaluation of anti-melanoma antibodies
… numerous studies have examined T cell-mediated immune responses to melanoma and their therapeutic potential, there has been less focus on B cell-mediated immune responses and the tumor-reactive antibodies they produce. The aim of this work was three-fold: (1) to develop a methodology to detect …
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