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Showing 1 to 20 of 46 for “"Immune dysregulation"”.

  1. Monogenetic Immune Dysregulation Syndromes and their Effect on the Plasma Cell Compartment

    Reid, Hayley MarieChristian-Albrechts-Universität zu Kiel

    Long-term immunity is shaped by the immune system's interactions with infectious agents or vaccinations. In individuals with immune dysregulation, such as patients with primary immunodeficiency (PID) or rheumatic diseases, these interactions are altered. Plasma cells (PC) and their B cell …

    cau-kiel Repository record

  2. DISSECTING IMMUNE DYSREGULATION IN PATIENTS WITHTHYMIC EPITHELIAL TUMORS BY AUTOANTIBODY ANDSINGLE-CELL PROFILING

    BALIN, SIMONEUniversità degli Studi di Milano2026

    … cells and the proportion of intratumoral immune cells. Prognosis progressively worsened from type A thymomas to TCs. Patients with thymomas showed an elevated susceptibility to paraneoplastic syndromes, in particular autoimmune diseases (ADs), which affects around 30% of thymoma patients. …

    milano Repository record

  3. Relationships between psychological factors and immune dysregulation in context: a life-course approach

    Hammond, Catherine CampbellUniversity of Essex2018

    … exposures, psychological responses to them and immune dysregulation. The approach taken is informed by theories about the life-course, the stress process, the stress response and the inflammatory theory of depression. The first two empirical chapters provide evidence about the contribution of …

    essex Repository record

  4. Adaptive Immune Responses to Vaccination Against SARS-CoV-2 in Individuals with Immune Dysregulation

    Horner, EmilyUniversity of Cambridge2024

    … utilised novel mRNA technology to produce an immune response against the viral spike protein. The efficacy of these vaccines was key to control the pandemic and beyond this, vital for the protection of individuals at high risk from disease. The pace of the expeditious approval and subsequent …

    cambridge Repository record

  5. Psychosocial Distress Mediates Immune Dysregulation Through Alterations in Global Epigenetic Patterns and Chromatin Remodeling Proteins

    Krukowski, Karen1970

    … and increased HPA activation can lead to immune dysregulation consisting of reduced natural killer (NK) cell activity (NKCA) (Biondi, 2001; Kiecolt-Glaser et al., 1987; Kiecolt-Glaser et al., 2002; Witek-Janusek et al., 2008; Witek-Janusek et al., 2007). This is of particular relevance to …

    loyola-thes Repository record

  6. Pathogenic Mechanisms Underlying Immune Dysregulation Associated To Hypomorphic RAG2 Mutation: Role Of Microbiota At Mucosal Interfaces

    Rigoni, RositaThe Open University2018

    … immunodeficiency associated with multisystem autoimmune–like manifestations, mediated by oligoclonal self-reactive T and B cells, named Omenn Syndrome (OS). The clinical and immunological spectrum of OS presentation is extremely broad. Commonly, patients present symptoms very similar to …

    the-open-u Repository record

  7. Investigations into the role of exogenous estrogenic endocrine disrupting chemicals on immune dysregulation in autoimmune disease

    Edwards, Michael RichardVirginia Tech2019

    … surrounding environmental exposure to EEDCs and immune system modulation. A commonly prescribed EEDC, 17α-ethinyl estradiol, is a synthetic analog of 17β-estradiol (E2), and is also found in many environmental reservoirs of human and animal exposure. Little is known regarding the immunomodulatory …

    vt Repository record

  8. PU.1-ACTIVATED GENOMIC REGIONS DEFINE LOW-RISK MDS SUBSETS CHARACTERIZED BY IMMUNE DYSREGULATION AND DISEASE PROGRESSION

    VALLELONGA, VERONICAUniversità degli Studi di Milano2025

    … by PU.1 genomic occupancy in regions linked to immune and inflammatory responses, increased T-cell and NK activation, and a higher frequency of SRSF2 mutations. Clinically, patients in this group exhibit greater susceptibility to infections and cardiovascular events, along with an elevated risk …

    milano Repository record

  9. Impact of Prenatal Alcohol Exposure on Cognition and Inflammation in Aging Male and Female Rats: A Longitudinal Approach

    Qureshi, SunnyBrock University2024

    … effects of PAE on cognitive functioning, immune system dysregulation, and neuroinflammation in aging rats with a focus on sex-specific differences. Using a well-established rat model of PAE, spatial learning and memory, recognition memory, serum cytokine levels and Iba-1 cell expression in …

    brock Repository record

  10. Mucosal Immunopathogenesis of Feline Immunodeficiency Virus (FIV)

    Howard, Kristina2006

    … of infection. FIV is an established model of HIV immune dysfunction but the mucosal pathogenesis of FIV infection has not been well studied. In the present study, we (1) identify the normal phenotype of feline small intestinal leukocyte populations; (2) characterize changes occurring in the …

    ncsu Repository record

  11. IL-2-Dependent Regulation of Immune Homeostasis and Response to Infection

    Hayes, Erika Therese2021

    Interleukin-2 (IL-2) is a critical regulator of immune homeostasis through its impact on both regulatory T (Treg) and effector T (Teff) cells. However, the precise role of IL-2 in the homeostatic maintenance and function of Treg cells in the adult peripheral immune system remains unclear. Here, we …

    washington Repository record

  12. Targeting Innate Immune Memory to Alleviate Monocyte Exhaustion and Chronic Inflammation

    Yajun, WuVirginia Tech2025

    … remain unresolved clinical challenges due to immune dysregulation. Innate immune cells, particularly monocytes, are key regulators of inflammation and its resolution. However, unbalanced or prolonged stimulation can drive these cells into dysfunctional states. These cells may enter …

    vt Repository record

  13. ROLE OF MICRORNAS IN THE PATHOGENESIS OF ATOPIC DERMATITIS

    LIEW WEN CHIY2018

    … is characterized by skin barrier defect and immune dysregulation. In this study, we investigated the role of microRNA in AD pathogenesis. We found miR-335 to be highly expressed in the differentiating layers of normal epidermis but downregulated in AD. miR-335 overexpression in cultured basal …

    nus Repository record

  14. SAFETY, EFFICACY, AND IMMUNOGENICITY OF SARS-COV-2 MRNA VACCINES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

    PREETI DHANASEKARAN2024

    … individuals, their safety and efficacy in autoimmune conditions like systemic lupus erythematosus (SLE), a type 1-interferon-driven disease, remain uncertain, as their mechanism of inducing T-cell-mediated responses and antibody production may risk exacerbating underlying immune dysregulation. …

    nus Repository record

  15. Human coronavirus NL63 envelope protein-protein interactions: role in pathogenesis

    Schoeman, DewaldUniversity of the Western Cape2024

    … (PDZ) domain-containing proteins, facilitating immune dysregulation and hyperinflammation. Early work on SARS-CoV-1 revealed that the PBM of its E protein serves as a pathogenic determinant, which was later supported by SARS-CoV-2 studies that demonstrated similar immunopathological outcomes. …

    western-cape Repository record

  16. Determinants of systemic treatment response in atopic dermatitis

    Sander, NicoleChristian-Albrechts-Universität zu Kiel

    … involves epidermal barrier dysfunction, immune dysregulation, and alterations of the skin microbiome. Despite major advances through targeted therapies, predictors of individual treatment response remain poorly defined. This thesis investigates systemic therapies for AD by integrating …

    cau-kiel Repository record

  17. Immune Cell Subsets Direct or Antagonize Tumor Immunity: Promotion of TH1 Responses in Tumor Vaccination

    Pressley, Jennifer SparkmanVirginia Tech2005

    Tumors evade immune system tumor-controlling functions. T cells critical to antitumor immunity are tolerogenic in tumor-burdened animals, and fail to lyse neoplastic cells. Our goal was to investigate the kinetics of immune dysfunction related to tumor-burdened host (TBH) memory T cell responses …

    vt Repository record

  18. Assessing The Outcomes of Blocking Ccl2-Ccr2 Signaling Axis On Breast Cancer Brain Metastasis

    Qi, Yutao, <p>0000-0001-8242-3880</p>2022

    … promoting brain metastasis outgrowth by driving immune suppression. Here, in this project we have been aiming to develop effective therapies by immune-modulating the roles of the CCL2-CCR2 signaling axis in immune dysregulation in brain metastasis. We demonstrated that CCR2 antagonism cannot …

    uthsc Repository record

  19. Dysregulated ERK signal pathway and immune profiles in Fragile X Syndrome

    Weng, NingUniversity of Illinois at Urbana-Champaign2012

    … account for the delay in ERK activation. FXS and immune dysregulation is an emerging area in FXS research. We hypothesize that immune cells from FXS patients may have different gene expression and protein profiles. We first analyzed genome-wide microarray data from FXS lymphoblastoid cell, and …

    uiuc Repository record

  20. An investigation of the regulation of Sialoadhesin ligands on CD4+ T cells and its potential significance in Systemic Lupus Erythematosus

    Kidder, DanaUniversity of Dundee2011

    … (Tregs) in a mouse model of experimental autoimmune Encephalomyelitis (EAE); however the nature of the interaction between Sn and CD4+ T cells is not well characterised. The first aim of this thesis was to investigate the upregulation of Sn ligand (SnL) on CD4+ T cells in vitro. Both Tregs and …

    dundee Repository record

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