Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Immune complex"”.
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Investigating the role of kidney mononuclear phagocytes in immune complex-induced inflammation.
… kidney MNP subsets at baseline and during autoimmune IgG immune complex (IC)-induced inflammation. We found that kidney MNPs could be divided into at least six subsets in healthy mice based on their expression of F4/80, CD11b and MHC II. These subsets differed in their localization within the …
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Genetic and Acquired Abnormalities in C3 Glomerulopathy and Primary Immune Complex-Mediated MPGN
… MPGN is currently classified in immune complex-mediated MPGN (IC-MPGN), characterized by activation of the complement classic pathway, and C3 Glomerulopathy (C3G), with predominant complement alternative pathway (AP) activation. C3G is further classified in Dense Deposit Disease …
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NZB/NZW F1-Derived Monoclonal Anti-Dna Autoantibodies: Dual-Specificity and Immune Complex Formation
The glomerulonephritis associated with the autoimmune disease Systemic Lupus Erythematosus (SLE) is mediated by immune complexes composed of DNA, complement components and anti-DNA autoantibodies, with the primary pathogenic antibodies being dsDNA specific. Recent studies had identified a …
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Roles of CCAAT/enhancer-binding protein [beta] and [-delta] in immunoglobulin G immune complex-induced Inflammation
… activation were induced in immunoglobulin G immune complex (IgG IC)-treated macrophages by using gel shift assays. The increased expression of C/EBP&beta and -&delta occurred at both mRNA and protein levels. Furthermore, induction of C/EBP&beta and -&delta was mediated, to a large extent, by …
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Clinical Presentation and Histopathological Description of the Spectrum of Renal Diseases in HIV Infected Adults Presenting With Renal Insufficiency at the University Teaching Hospital,Lusaka Zambia
… than HIVAN. A group of diseases known as HIV immune complex kidney diseases have gained prominence in this regard. Other diseases include acute tubular necrosis, acute and chronic interstitial nephritis, haemolytic uremic syndrome and many others. Objective: To determine the clinical …
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Clinical Presentation and Histopathological Description of the Spectrum of Renal Diseases in HIV Infected Adults Presenting With Renal Insufficiency at the University Teaching Hospital,Lusaka Zambia
… than HIVAN. A group of diseases known as HIV immune complex kidney diseases have gained prominence in this regard. Other diseases include acute tubular necrosis, acute and chronic interstitial nephritis, haemolytic uremic syndrome and many others. Objective: To determine the clinical …
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A ten year retrospective study of the aetiology and outcome of crescentic glomerulonephritis in children presenting to the Red Cross Children's Hospital, Cape Town, South Africa
… sub-types of crescentic glomerulonephritis were immune-complex in 19 (80%), Pauci-immune in 2 (8 %), unspecified type in 3 (12 %) and no child had the anti-glomerular basement membrane subtype. The underlying aetiology of the immune complex sub-type was post-infectious in 11(57.9%), idiopathic in …
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Developmental Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Induced and Exacerbated Autoimmunity in Adulthood
… (TCDD) exposure can permanently alter immune system ontogeny, resulting in the dysregulation of a number of vital immune pathways. We hypothesized that developmental exposure to TCDD may also impair the establishment of self-tolerance, resulting in an increased risk of autoimmunity. For …
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Tissue-resident immunity in the human kidney
… these cells lies a network of tissue-resident immune cells with incompletely characterised roles in tissue homeostasis, repair, and defence. Furthermore, different regions of the kidney are affected by distinct immunologically relevant insults - ascending bacterial infection in the …
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Molecular Players in Lupus: Leads from Proteomic Screens
… Erythematosus is a multifactorial systemic autoimmune disorder marked by anti-nuclear antibodies (ANA), rashes and photosensitivity, joint inflammation, nephritis, and other clinical criteria. SLE develops through the breakdown of three major checkpoints: adaptive immune tolerance, peripheral …
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Immune memory and activation markers in systemic lupus erythematosus
… (SLE) is a chronic inflammatory autoimmune disease characterized by the loss of tolerance to self-antigens, immune complex deposition, tissue inflammation and destruction. SLE manifestations, prevalence and severity vary among different populations and ethnicities. Even today, the …
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Larval Hemolymph Proteins and Physiological Role of Prophenoloxidases in Anopheles Gambiae
… vectors for human malaria. Understanding its immune system may provide new means for disrupting the disease transmission. While the Drosophila melanogaster and Manduca sexta immune systems are well studied, most components ofthe mosquito system remain to be examined. Insect hemolymph contains …
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Metal binding to transferrin and immune reactions in Parkinson's disease
… controls suggesting the activation of a cellular immune response. Furthermore, plasma neopterin was lower in treated compared to untreated PD patients, although the difference was not significant. There was no evidence for the activation of the humoral immune response in untreated or treated PD …
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The Role of ADAM10 in the Immune System: Maintenance of Lymphoid Architecture, MDSC Development and Function, B cell Derived Exosomal Antigen Presentation, and B1 cell IgE Production.
… study, we examined the role of ADAM10 in the immune system. Here, we show that knocking out ADAM10 on the mature B2 cell causes a defect in the development of secondary lymphoid architecture that becomes more severe post-immunization. We also show that overexpression of ADAM10 leads to a …
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The Impact of IL-9 on Disease in Murine Models of Systemic Lupus Erythematosus
… is a relapsing-remitting antibody-mediated autoimmune disease characterized by systemic immune complex deposition. A subset of SLE patients has been shown to have elevated CD4+IL-9+ T cells as well as increased secreted IL-9 and Il9 mRNA compared to healthy controls. In other antibody mediated …
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Next-Generation Sequencing for New Gene Identification and for Diagnosis in Steroid-Resistant Nephrotic Syndrome
… in conditions commonly associated with NS: the immune complex-mediated membranoproliferative glomerulonephritis (IC-MPGN), the C3 glomerulopathy (C3G) and the podocytopathies, usually characterized by steroid-resistant nephrotic syndrome (SRNS). The first part of the thesis focused on IC-MPGN …
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Investigation of the role of copy number variation in the susceptibility to systemic lupus erythematosus
… erythematosus (SLE) is a chronic systemic autoimmune disease characterised by immune complex deposition and production of autoantibodies against nuclear antigens (ANA). The aetiology of SLE is complex; however, twin and genome-wide association (GWA) studies clearly indicate that SLE has a …
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Investigation of the role of copy number variation in the susceptibility to systemic lupus erythematosus
… erythematosus (SLE) is a chronic systemic autoimmune disease characterised by immune complex deposition and production of autoantibodies against nuclear antigens (ANA). The aetiology of SLE is complex; however, twin and genome-wide association (GWA) studies clearly indicate that SLE has a …
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