Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Immune cell infiltration"”.
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Anti-VEGF Therapy Modulates Immune Cell Infiltration and Function in Multiple Breast Cancer Models
… cancer is initiated when mammary epithelial cells acquire mutations in genes that regulate cell proliferation, survival, polarity, and differentiation. However, a growing body of evidence indicates that the stromal cell response to these malignant cells participates in tumorigenesis and is …
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Investigating the protective effects of intestinal GABA[subscript A] receptor activation on an animal model of Multiple Sclerosis
… are found not only in the CNS, but also in T cells and within the intestines. Past studies have indicated that GABA can have an anti-inflammatory effect and production of GABA by gut bacteria decreases in patients with multiple sclerosis (MS). We examined whether administration of a positive …
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Role of Slit2 in Reducing Complications after Surgical Brain Injury
… water and plasma proteins as well as peripheral immune cell infiltration into the brain parenchyma that further potentiates brain edema and worsens post-operative neurological function. Activated resident immune cells and infiltrated peripheral immune cells release inflammatory mediators and …
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Investigation of local South African avipoxviruses as potential vaccine vectors
… use as vaccine vectors as a result of their excellent safety profile and host range restriction. In this study, 8 novel South African (SA) avipoxvirus isolates were characterized. They could be divided into five groups, according to gross pathology and pock appearance on CAMs. Histopathology …
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Absence of Enhancer of Zeste Homolog 2 Promotes the Progression of KRAS-Driven Pancreatic Ductal Adenocarcinoma
… but did affect progression, and reduced immune cell infiltration, suggesting a role for EZH2 in limiting early progression of KRASG12D-mediated PDAC.
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Investigating The Role of Abro1 In Dna Damage-Induced Immune Response
… such as enlarged spleens, increased numbers of T cells and B cells, elevated levels of IL6 and TNF-alpha in the blood, and increased immune cell infiltration in major organs. Recently, it has been shown that genomic instability can trigger cGAS/STING pathway , inducing activation of the innate …
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Imaging Glioblastoma metabolism using mass spectrometry imaging
… characteristics such as proliferation rate, immune cell infiltration, hypoxia, or vascularisation. Growing cells outside the primary tumour as primary cell lines and then implanting them orthotopically into rodent brains did not change their metabolic phenotype. In addition, modulation of the …
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The Role of Ganglioside GD2 and GD3 Synthase (ST8SIA1) in the Regulation of Immune Suppression in Breast Cancer
… are acidic glycosphingolipids involved in cell adhesion, proliferation, and modulation of signal transduction pathways. It has been reported that tumor-shed gangliosides influence the activity of immune cells including macrophages, NK cells, and T cells. GD3 synthase (GD3S) is the key …
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Inflammatory astrocyte and T cell interactions are supported by hyaluronan in a murine model of Multiple Sclerosis
Multiple Sclerosis (MS) is an autoimmune disorder characterized by demyelination, neurodegeneration, and immune cell infiltration into the central nervous system (CNS). Inflammatory astrocytes, one of the first described subtypes of reactive astrocytes, are thought to play a role in the development …
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Ketogenic Diet is Protective During Endotoxin-Induced Lung Injury
… by uncontrolled lung inflammation with excessive immune cell infiltration, which eventually leads to severe pulmonary edema and poor oxygenation. ARDS affects hundreds of thousands of people a year, particularly those afflicted with sepsis or other critical illnesses. So far, there is a lack of …
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Cystatin C and sex dimorphism in experimental autoimmune encephalomyelitis
… allergic encephalomyelitis (EAE). MS is an autoimmune disease characterized by infiltration of myelin reactive immune cells into the central nervous system (CNS) that is more prevalent in genetically susceptible women compared to men. Alteration in the level of CysC in the CNS of MS patients is …
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Molecular basis of immunotolerance in canine neoplasia
… highly immunogenic neoplasm, the function of the immune system is hampered by the expression of immune checkpoint molecules by the cancer cells. In contrast, soft tissue sarcomas are poorly immunogenic, as Tumor infiltrating Lymphocytes are lacking, or when present they are usually at the …
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Host-intrinsic factors determine anti-tumor efficacy of exercise in pancreatic ductal adenocarcinoma
… effect of exercise on tumor infiltrating immune cells.</p> <p>We interrogated tumor stromal composition changes with exercise and observed a gut microbiome dependent reduction in alpha smooth muscle actin (αSMA<sup>+</sup>) cells and <em>Il6</em> expressing inflammatory cancer associated …
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Effects of Penfluridol On Integrin-Fak Signaling and Tumor Cell Killing In Combination With Oncolytic Hsv In Glioblastoma
… an important role in activating multiple intracellular pathways, one of which is focal adhesion kinase (FAK). Phosphorylation of FAK can lead to the activation of various downstream signaling pathways that can increase tumor cell growth and proliferation, making it an ideal target for cancer …
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Exploring the immune landscape of the tumour microenvironment in meningiomas and the role of immune infiltration in meningioma models
… alterations. <br/>Aims: To investigate the immune landscape of meningiomas classified by grades, genotypes and methylation classes (MCs), and to elucidate the role of the TAMs in meningioma progression utilising a patient-derived 3D co-culture model.<br/>Methods: Multiplex …
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Somatic Mutations in Primary Sjögren’s Syndrome
… understanding of the pathogenesis of autoimmune diseases continues to elude us. In this thesis, I explore the hypothesis that somatic mutations may underpin the development and progression of autoimmune disease, specifically primary Sjögren’s syndrome (PSS). PSS is a chronic, systemic …
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The role of adaptive immunity in Parkinson's pathology following traumatic brain injury
… development later in life, but the molecular and cellular mechanisms are unknown driving this relationship. A single, mild brain injury can activate both resident and peripheral neuroinflammatory signaling pathways that are similarly activated in the brains of PD patients, likely increasing …
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Identification and Application of Novel Therapeutic Targets for PRPH2-Associated Disorders
… following early intervention and reduced immune cell infiltration following late intervention. These results show modulation of OS structural abnormalities to be a viable option for amelioration of retinal degeneration. In parallel studies, we investigated the role of metabolic …
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The Role of the Mitogen Activated Protein Kinase Pathway in Cisplatin and Noise-Induced Hearing Loss
… two main causes of hearing loss. There are many cellular pathways involved in both types of hearing loss and the mitogen activated protein kinase (MAPK) pathway is one. The MAPK pathway consists of a phosphorylation cascade with RAF, MEK1/2, ERK1/2 as the main three kinases that effect a …
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Integrative analysis of the metastatic neuroblastoma transcriptome
… expression patterns in MYCN-amplified tumors and cell lines, and binding motifs for these factors were significantly enriched in differentially-spliced genes. ChIP-seq analysis showed direct binding of MYCN to promoter regions of splicing factors PTBP1 and HNRNPA1, demonstrating that MYCN …
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