Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Immune cell fate"”.
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Metabolic control of immune cell fate by hypoxia-inducible factors
… for life and is a major determinant of mammalian cell fate. Vital systems are driven by the activity of oxygen-dependent enzymes within fundamental processes, such as cellular metabolism and gene transcription. The hypoxia-inducible factors (HIFs), which are regulated by oxygen-sensing …
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Mechanistic Insights on The Immunomodulatory Functions of Diverse Environmental Factors on Systemic Autoimmunity
The immune defense is geared to protect against a tremendous array of invaders. The ultimate goal of the immune system is to induce effective and balanced inflammatory responses that enable the efficient elimination of possible threats while avoiding both immunodeficiency and autoimmunity. The …
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Metabolic Disorders Rewire Systemic and Tumor Immunity to Shape Anti-Tumor Responses in Cancer Patients
… higher cancer incidence and respond poorly to immune checkpoint inhibitors and cellular therapies. Rather than acting solely on tumors, metabolic dysfunction dismantles antitumor immunity both locally and distally. Distally, chronic systemic inflammation and stromal remodeling distort the …