Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 136 for “"Immune Systems"”.
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Enhancing real-time embedded systems development using artificial immune systems
… Electronics industry produces a large number of systems which exhibit both real-time and embedded properties (RTES). Frequently problems are encountered during the development of these systems due to a mismatch between the requirements of traditional real-time development techniques and the …
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Ancient Immune Systems: Sensing and Signaling in Bacterial-Phage Conflict
… of bacterial defense mechanisms [1]. These systems are thought to have provided the evolutionary foundation for numerous eukaryotic immune strategies [2]. Experimental studies have validated many of these anti-phage defense systems and revealed the mechanisms by which they disrupt phage …
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Structural Damage Assessment Using Artificial Neural Networks and Artificial Immune Systems
<p>Structural health monitoring (SHM) systems have been technologically advancing over the past few years. Improvements in fabrication and microelectronics allow the development of highly sophisticated sensor arrays, capable of detecting and transmitting an unprecedented amount of data. As the …
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Molecular Mechanisms of Sensing and Synergy by Anti-Bacteriophage Immune Systems in Staphylococcus
… across all domains of life have evolved immune strategies in the form of genetically encoded systems to defend themselves. Immunity can be conceptualized as occurring in three fundamental stages. First, the immune system must identify an invading pathogen— either directly via recognition …
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Aircraft Abnormal Conditions Detection, Identification, and Evaluation Using Innate and Adaptive Immune Systems Interaction
… and evaluation based on the artificial immune systems paradigm, which has the capability to address the complexity and multidimensionality issues related to aircraft systems.;Within the proposed framework, a novel algorithm was developed for the abnormal conditions detection problem and …
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Inheritance, innovation, and adaptation of immune systems: Regulation of the Innate Immunity Sensor Stimulator of Interferon Genes (STING)
… represent a common focus across various living systems. Recent advancements have shed light on the structural similarities observed in multiple innate immune proteins shared between bacteria and humans. These findings suggest the evolutionary origins of certain human innate immune genes from …
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Are bats evolving more potent antiviral immune systems? Investigating the evolution and antiviral capacity of SERINC3 in Rhinolophus bats
… and abundant viral reservoir species. Their immune systems are uniquely anti-inflammatory and anti-viral, often tolerating viral infection without any signs of disease. Several pandemic and emerging viruses have been traced back to different bat species, including SARS-CoV-2, SARS, Ebola …
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Studies on Real-Valued Negative Selection Algorithms for Self-Nonself Discrimination
The artificial immune system (AIS) is an emerging research field of computational intelligence that is inspired by the principle of biological immune systems. With the adaptive learning ability and a self-organization and robustness nature, the immunology based AIS algorithms have successfully been …
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Anti-phage defense as a driver of molecular innovation
… force for the creation of bacterial defense systems and corresponding phage evasion strategies. To counter phage predation, bacteria have developed a vast diversity of enzyme chemistries and molecular sensing mechanisms whose study has produced new biotechnological tools and insights into our …
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Sympathetic Neural Control of Inflammation by ADRB2-Mediated IL-10 Secretion
The nervous and immune systems reciprocally regulate their functions through the release of chemical messengers. Norepinephrine (NE), a neurotransmitter released by catecholaminergic nerve endings, allows the sympathetic nervous system to communicate with immune cells through adrenergic receptors …
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Stochastic regulation of signaling in lymphocytes
… bacteria, etc. But we survive thanks to our immune systems. One of the important immune systems is the adaptive immune system, which mounts pathogen specific immune responses. The orchestrators are lymphocytes, including B cells and T cells. When lymphocytes are stimulated strongly enough by …
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Mechanisms of phage detection by bacterial innate immune proteins
… As a result, bacteria have evolved diverse immune mechanisms to protect themselves from phage infection, such as restriction modification, CRISPR-Cas, and abortive infection (Abi) systems. Because Abi systems function through killing infected cells to protect the bacterial population, they …
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The Immune Status of Two Bloom's Syndrome Siblings
… in question. Procedure. This study examined the immune reactions of these siblings with such tests of immune function as: T- and B-cells, T-cell subsets, chemotaxis, nitroblue tetrazolium (NBT), mitogen stimulation and mixed lymphocyte culture (MLC). Findings. Results are compared with those of …
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The Role of Prolactin in CCL28 Regulation
Infants are born with naive immune systems, making them susceptible to a variety of infections. In order to protect the newborn infant it is important that mothers be able to pass protective IgA antibodies to their infants through breast milk. B cells that produce IgA enter the mammary tissue …
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Precise and expansive genomic positioning for CRISPR edits
The recent harnessing of microbial adaptive immune systems, known as CRISPR, has enabled genome-wide engineering across all domains of life. A new generation of gene-editing tools has been fashioned from the natural DNA/RNA-targeting ability of certain CRISPR-associated (Cas) proteins and their …
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Equine obesity-related hyperleptinemia
… effects of hyperleptinemia on the endocrine and immune systems. Endotoxin was given to mares and geldings to investigate the role and/or regulation of leptin in the pro-inflammatory cytokine response. Of the endpoints measured, only platelet count differed between normal and hyperleptinemic …
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Structure-Activity Studies of Glycosphingolipids as Antigens of Natural Killer T Cells
… natural killer T (NKT) cells of the innate immune system. Critical to the recognition of glycosylceramides by NKT cells are antigen presenting cells (APC), such as dendritic cells, which are responsible for binding, processing, and delivery of ligands to these lymphocytes. This event is …
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Development of novel antibody-based diagnostics for the early and rapid detection of cardiac markers
… antibodies and recombinant fragments. The immune systems of mice, rabbits and chickens were investigated in this work, which allowed for the identification of the main advantages and disadvantages associated with each of the host immune systems and their capacity for generating specific and …
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Diversity and Evolution in the Avian Major Histocompatibility Complex
… the chicken has one of the best-understood immune systems, largely due to the interests and investment of the commercial poultry industry. The chicken Major Histocompatibility Complex (MHC) has been particularly well-studied, since variation at the chicken MHC is strongly associated with …
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