Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"Immune System Diseases"”.
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Žmogaus mezenchiminių kamieninių ląstelių genetinių savybių tyrimas saugiai terapijai užtikrinti /
… holds promise for treating degenerative and immune system diseases and repair of damaged tissues. Human tissues are cryopreserved and isolated MSCs are expanded in various culture media when prepared for clinical applications. These manipulations can significantly alter the MSC genetic …
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Investigation of human mesenchymal stem cell genetic characteristics to ensure therapy safety /
… holds promise for treating degenerative and immune system diseases and repair of damaged tissues. Human tissues are cryopreserved and isolated MSCs are expanded in various culture media when prepared for clinical applications. These manipulations can significantly alter the MSC genetic …
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Developing a vector for expressing serratiopeptidase in Lactococcus lactis
… these treatments, supplementing the body with systemic enzymes may attenuate inflammation. One promising enzyme is serratiopeptidase. Serratiopeptidase is a serine protease expressed by Serratia marcescens which has demonstrated anti-inflammatory, anti-edemic, and analgesic activity in …
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Human Immunodeficiency Virus and Acquired Immune Deficiency : Beliefs, Knowledge, and Behaviors of High-School Students Attending Seventh-day Adventist Academies
<p>Problem. Few attempts have been conducted to assess knowledge of HIV/AIDS in the adolescent population attending Seventh-day Adventist secondary schools. This present study was to investigate the HIV/AIDS-related beliefs, HIV/AIDS-related knowledge, and HIV/AIDS-related behaviors of adolescents …
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Effects of GABA on inflammation and intestinal barrier disruption
… Our previous works show that experimental autoimmune encephalomyelitis (EAE) induction modifies the gut's microbiota composition, reducing frequencies of gamma-aminobutyric acid (GABA)-producing bacteria. GABA levels are reduced in the brains and circulation of MS patients. We engineered …
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Investigating the protective effects of farnesol formations against neuroinflammation
… are mechanisms associated with CNS demyelinating diseases, we sought to determine whether FOL treatment would result in protection against experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. We demonstrate that there is a correlation between reduced …
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Multiple Psychosocial Factors as Predictors in the Progression of HIV-1 to AIDS
… psychosocial factors, the central nervous system, the immune system, and disease. From this perspective, this study reviews the biopsychosocial medical model and components of the stress-immunity-health (SET) model. The constructs of stress and social support are discussed and defined …
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The Life Story Analysis of Those Suffering from Autoimmune Thyroiditis
… was to understand the pervasive impacts of autoimmune thyroiditis, specifically Hashimoto’s and Graves’ disease. To accomplish this, the life story methodology was utilized to gather individual experiences from 11 participants diagnosed with Hashimoto’s or Graves’ disease. The participants …
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Intact Families with a Multiple Sclerotic Parent: Social and Emotional Adjustment of Parents and School-Age Children
<p>Problem Statement. Research on children with a multiple sclerotic parent has been minimal and until recently focused only on negative aspects. This study investigated how families successfully cope with multiple sclerosis (MS) and how their school-age children are affected, positively or …
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The Cx3Cl1-Cx3Cr1 Chemokine Axis Contributes to Tumor Immune Evasion and Its Blockade Enhances Responses to Anti-Pd-1 Immunotherapy
… While CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration, the mechanisms employed by this axis on these cells to mediate immune suppression remain poorly understood. Here, we explore the immune evasion strategies implemented by this axis and …
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Enhancement of anti-HIV-1 Ribozyme Activities by Rev Binding and Multimerization
<p>To effectively apply hammerhead ribozymes as therapeutic agents it is necessary to co-localize them with the desired target. Human immunodeficiency virus type1 (HIV- 1) infectivity is dependent on <em>env</em> gene expression. HIV-1 Rev protein binds to a higher ordered RNA structure within the …
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Development of Catalytic RNAs as Potential Anti-HIV-1 Agents
… ribozyme can be increased by a lipid-delivery system (liposome). Experiments utilizing a liposome delivery system into human H9 lymphocytes are described.</p> <p>Finally, this study describes the use of the yeast Saccharomyces cerevisiae as eukaryotic model for studying ribozyme expression and …
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African American women and HIV prevention
<p>For many health conditions, non-Hispanic Blacks bear a disproportionate burden of disease, injury, death, and disability. The purpose of this study was to examine African American females and their HIV prevention methods, as well as to identify factors that may lead to the non-use of condoms. …
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Effect of anti-microbial immunizations in the progression of amyloid and neuroinflammatory pathologies in a mouse model of Alzheimer's disease
… microorganisms that affect the respiratory system to evaluate their effect in the progression of amyloid and neuroinflammatory pathologies. iv Lipopolysaccharide (LPS) injections and immunizations against coronavirus disease 19 (COVID-19), influenza and pneumonia, were administered to …
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Uncovering Novel Mechanism of Immune Modulation of Invariant Natural Killer T Cells By Liposomal Α-Galactosylceramide
… T cells (iNK-T cells) are a powerful regulatory immune cell that can recruit both innate and adaptive immune cells. Unlike conventional T cells (CD4<sup>+ </sup>and CD8α<sup>+</sup>), they recognize glycolipid antigens via the MHC-class-I like molecule, CD1d. A synthetically derived glycolipid …
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Psychosocial Predictors of Survival in Persons with HIV or AIDS
… be addressed, specifically the rebuilding of immune system. Both HIV and AIDS have a variable course in disease progression. The field of Psychoneuroimmunology proposes a mechanism by which psychosocial variables could impact immune function and may serve to exacerbate or be protective of …
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Genetic Exploration of Hereditary Immune Diseases
<p>An autoimmune disease is a condition arising from an abnormal immune response to a normal body part. There are at least 80 types of autoimmune diseases, rheumatoid arthritis and systemic sclerosis are two of them. My study focuses on these two diseases. Our hypothesis is that mutated genes lead …
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Determining the Roles of Q-SNAREs in Mast Cell Tumor Necrosis Factor Exocytosis
<p>As evidence accumulates on the contributions of mast cell function to the development of allergic disorders, cardiovascular and neurological pathologies, and cancers, there is a growing recognition of the importance of mast cell-derived TNF to mast cell-mediated pathophysiology. However, our …
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Autoimmune Consequences of Histone Deimination during Neutrophil Activation
… for the understanding and treatment of autoimmune diseases. Evidence implicates cell death and autoantigen modifications in the initiation of autoimmune reactions. One form of neutrophil cell death deserves attention because it occurs as a consequence of neutrophil activation, requires the …
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