Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Immune Synapse"”.
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How TCR signal strength controls CTL polarisation for target killing
… (CTL) are major effector cells in the adaptive immune response against intracellular pathogens and cancers, killing targets with high precision. Precision is achieved through the specificity of the clonally expressed T cell receptor (TCR). TCRs recognise a specific peptide chain loaded into a …
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T cell receptor- and calcium-induced Gli signalling in CD8+ T cell effector function
… (CTLs) are potent effector cells of the immune system, capable of directly lysing neoplastic and infected cells. The Hedgehog (Hh) signalling pathway - a critical regulator of embryonic development and adult tissue maintenance - is induced in CTLs following TCR stimulation and has been …
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NKG2D Ligands in Cancer
… expression of adhesion molecules to mediate immune-synapse formation. Because these resistance mechanisms are readily amenable to therapeutic alteration, NK cell transplantation holds promise for future cancer therapy.</p>
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HEDGEHOG SIGNAL TRANSDUCTION IN EFFECTOR IMMUNE CELLS
… the Hh pathway impacts the kinetics of NK immune synapse formation, without affecting cytotoxic granule content and release or cytokine production. Importantly, I demonstrate that amplification of Hh signalling in human NK cells can enhance tumour cell killing. Next, I show that T cells can …
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Novel Imaging-Based Techniques Reveal A Role For Pd-1/Pd-L1 In Tumor Immune Surveillance In The Lung
<p>The binding of immune inhibitory receptor Programmed Death 1 (PD-1) on T cells to its ligand PD-L1 has been implicated as a major contributor to tumor induced immune suppression. Clinical trials of PD-L1 blockade have proven effective in unleashing therapeutic anti-tumor immune responses in a …
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Role of Stat3 In Human Nk Cell Functions
… lymphocytes, which play a critical role in the immune response against malignant cells and microbial infections. NK cells are equipped with activating receptors, which upon detecting ligands expressed on stressed cells induce cytolytic activity of NK cells. Stimulation of NK cell proliferation …
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Cytotoxic T lymphocyte biology under the microscope
… (CTLs) are essential agents of the adaptive immune system that seek out and destroy virally infected or cancerous cells. Incapacitate them and you become severely immunocompromised and riddled with tumours (à la prf1-/- mouse model); enhance them and you can beat previously unbeatable cancers …
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Novel peptide antigens provide insights into the recognition process by T cells
… clustering of TCR-peptide/MHC complexes in the immune synapse. The third chapter in this thesis details a project examining the contributions of position 97 of the murine MHC allele Ld in affecting peptide binding. A 2010 study published by the International HIV Controllers Study group described …