Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Immune Phenotype"”.
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Assessing the immune phenotype of cardiac syndrome x: a prospective study of biomarkers
… in CSX patients. This could allow phenotype switching in vascular smooth muscle cells with the resultant vascular remodelling causing reduced vessel responsiveness to local rheological stimuli and reduced luminal diameter with consequent increased microvascular resistance during …
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HUMAN GENETIC VARIANTS IN ESSENTIAL SPLICING FACTORS AND THEIR IMPACT ON IMMUNE PATHOLOGY
… neurodegenerative disorders, cancers and autoimmune diseases. Splicing is a multi-step process executed by the spliceosome, which is composed of five small nuclear ribonucleoproteins (snRNPs) and hundreds of proteins that are generally referred to as splicing factors (SFs). Here we present two …
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Tuberculosis and genes of the IL12/IL23/IFNγ pathway: Exploring functional significance of novel mutations in the IL12p40 promoter
… was done by reporter assay and immunological phenotype was investigated by measurement of cytokines levels and cytokine receptor expression. WAVE screening identified two heterozygous SNPs, -1523 A/G and -1564 C/T. Statistical analysis showed that -1523 A/G may be protective against TB disease …
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Novel Imaging-Based Techniques Reveal A Role For Pd-1/Pd-L1 In Tumor Immune Surveillance In The Lung
<p>The binding of immune inhibitory receptor Programmed Death 1 (PD-1) on T cells to its ligand PD-L1 has been implicated as a major contributor to tumor induced immune suppression. Clinical trials of PD-L1 blockade have proven effective in unleashing therapeutic anti-tumor immune responses in a …
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Heterologous Prime-Boost strategies using live-attenuated and viral vector vaccines to combat pneumonic plague
… regimen). The 2-dose regimen induced robust immune responses to provide full protection to animals against parental CO92 and its isogenic F1 (CAF-)-deletion mutant challenges during both short- and long-term studies. While all of these approaches were completely protective, differences in the …
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Heterologous Prime-Boost strategies using live-attenuated and viral vector vaccines to combat pneumonic plague
… regimen). The 2-dose regimen induced robust immune responses to provide full protection to animals against parental CO92 and its isogenic F1 (CAF-)-deletion mutant challenges during both short- and long-term studies. While all of these approaches were completely protective, differences in the …
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Characterization of Chronic Glucocorticoid Exposure on Natural Killer Cell Function: A Model for Stress Induced Alterations on the Epigenetic Landscape
<p>Psychological stress can impact immune function through altered glucocorticoid production. Natural killer (NK) cells and their effector functions are particularly susceptible to both psychological stress as well as exogenous glucocorticoids. The purpose of this study was to assess the impact of …
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Fusion Proteins as Selective Inducers of Constitutive Activity and Tools to Discriminate the Biased Signaling Profile of β2 Adrenoceptor Ligands
… Th1 or Th2 inflammatory response regulating the immune phenotype of respiratory diseases. Our data implies our fusion proteins can be used as tools to isolate the function elicited by a unique signaling pathway in physiologically relevant cell types.
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Exploring the Role of IL-1β/IL-1R in the Pathogenesis of K-ras Mutant Lung Cancer
… shown that IL-1β blockade promotes an anti-tumor immune phenotype in a mouse model of KM-LUAD driven by lung epithelial cell-specific expression of K-ras<sup>G12D</sup> (CCSP<sup>Cre</sup>/LSL-K-ras<sup>G12D</sup>, CC-LR mouse), suggesting that IL-1β mediates tumor-promoting inflammation. Yet, …
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KUPFFER CELLS¿ MITOCHONDRIAL PLASTICITY AFFECTS SYSTEMIC IMMUNO-METABOLISM
… within the hepatic niche, playing both an immune and metabolic role. As a result, KCs require large amounts of energy to perform their functions, which is why mitochondria turn out to be critical for their functioning. Among the mitochondrial proteins that regulate their dynamism, OPA1 is …
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Probiotic Modulation of Mucosal Immune Responses in an In Vitro Co-Culture Model
… many mechanisms including modulation of the gut immune system. Gut mucosal macrophages play a pivotal role in driving mucosal immune responses. The local environment and macrophage subset determine immune response: tolerance, associated with an M2-like, regulatory macrophage phenotype and …
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Nasal Associated Lymphoid Tissue in health, infection and autoimmunity
The immune system exists in three core components - epithelial surface barrier immunity to prevent entry of foreign antigens from the environment; innate immunity to provide an immediate but non-specific cellular immune defence response to foreign antigens; and an adaptive immune response providing …
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Mediators of monocyte activity in inflammation
… of pro-inflammatory cytokines, which alters the immune phenotype of circulating monocytes. Vitamin C supplementation reduced monocytic adhesion to endothelial cells, but had no effect on serum levels of CRP. Where long-term antioxidant intervention may provide benefit from the risk of developing …
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Can levamisole upregulate the equine cell mediated immune response in vitro?
… Some EPM affected horses have decreased immune response. A cell-mediated immune response has been shown to be protective for development of EPM after infection with Sarcocystis neurona in mouse models. Levamisole has been proposed as an adjunctive therapy for EPM to upregulate the …
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Polysequence Nanomaterials for Immunomodulation
… which promote anti-inflammatory and TH2 immune responses. We created an immunomodulatory supramolecular nanomaterial system inspired by the randomized nature of glatiramoids termed KEYA-Q11. By creating a glatiramoid-like peptide library integrated within self-assembling Q11 nanofibers, …
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Cellular Immune Changes in the Peripheral Blood of Subjects Chronically Infected with XMRV
… chronically alter the regulation of the innate immune system causing immunosuppression. Recently, evidence of a new human retrovirus, Xenotropic murine leukemia virus-related virus, XMRV, was detected in the blood of >67% of 101 Chronic Fatigue Syndrome (CFS) patients tested and shown to be …
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Genomic investigation of primary immunodeficiency
… which effect one or more components of the human immune system and are typically considered monogenic. PID presents with features including increased susceptibility to infection, autoimmunity, autoinflammation, atopy and malignancy. The list of genes associated with these inborn errors of immunity …
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Investigating the role of PABPC5 in mouse physiology
… did not show any discernible trends. Second, an immune phenotype that emerged during the initial characterisation of Pabp5 knock-out male mice was briefly explored. Male mice lacking Pabp5 exhibited a global decrease in the number of circulating white blood cells. The number of lymphocytes and …
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Investigation of ACE-overexpression in Myeloid Cell Lines through Whole-Proteome Analysis
… in other biological systems and disease. In the immune system, ACE and angiotensin II influence inflammation and wound repair. Independently of angiotensin II, ACE overexpression in murine macrophages (ACE 10/10) and neutrophils (NeuACE) has shown remarkable enhanced immune phenotypes with the …
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Genetic characterization of Rpp1-mediated Asian soybean rust resistance using in-depth transcriptomic and genomic analyses
… lesions with no or limited sporulation, or immune phenotype of the incompatible interaction that show miniscule or no lesions and no sporulation. Due to the rapid changing nature of rust effector proteins to avoid being detected by the resistant genes, and to the spectrum of …