Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 132 for “"Immune Evasion"”.
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Tuberculosis transcriptomics: host protection and immune evasion mechanisms
… manner to pinpoint novel host protection and immune evasion genes and elucidate the role of these genes in vitro macrophage assays and in vivo knockout mouse studies. The data in this thesis showed that basic leucine zipper transcription factor 2 (Batf2) was an important factor that regulates …
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Innate immune evasion and interferon antagonism by porcine epidemic diarrhea virus
… in the order Nidovirales. The innate immune system is the first line of host defense in response to viral infections. Type I interferons (IFN-α/β) are the major components of the innate immune system, and in turn many viruses have evolved to modulate the host interferon responses. In …
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Genetic alterations defining human primary melanoma and mechanisms of immune evasion
… also help shape how tumours evolve and escape immune regulation. Studying these changes can therefore help to refine our understanding of melanoma progression with the added potential to offer new perspectives for disease management. Most prior melanoma sequencing studies have focused on …
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The role of staphylococcal superantigen-like protein 7 (SSL7) in immune evasion
… virulence factors that interfere with the host immune defence. Staphylococcal superantigen-like (SSL) proteins comprise a family of virulence factors suspected to target key components of the innate immune system and promote host colonisation and immune evasion. This thesis examined SSL7, a …
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UNCOVERING IMMUNE EVASION MECHANISMS FOR THE PROGNOSIS AND THERAPY OF ENDOMETRIAL AND OVARIAN CANCERS
… biology and interactions between cancer and the immune system is essential for the recognition and development of potential new immunotherapeutic strategies and targets as well as the optimization of existing immunotherapies. Therefore, the aim of this thesis was to characterize the molecular …
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Putative Roles of Cd200 In The Leukemogenesis and Immune Evasion of Leukemia Stem Cells
… that AML LSCs can be eliminated by the immune system, the translation of existing immunotherapies to AML have been met with limited success. Consequently, understanding and exploiting the unique immune mechanisms of AML LSCs is critical. To identify novel immunotherapeutic targets, we …
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Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion
<p>Glycosylation of immune receptors and ligands, such as T-cell receptor (TCR), major histocompatibility complex (MHC), and co-inhibitory molecules, regulates immune signaling activation, antigen presentation, and immune surveillance. Recent studies revealed that the glycan structures of …
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Impact of Tumor Cell Expressed CD38 on Metastasis and Immune Evasion in Breast Cancer
… hybrid EM murine tumors are enriched in CD38, an immunesuppressive molecule associated with worse clinical outcomes in liquid malignancies but relatively understudied in solid tumors such as breast cancers. Hence, we sought to investigate the role of CD38 in hybrid EM-driven metastasis using …
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Dissecting the Roles of Cancer Cell Lipid Metabolism in Tumor Progression and Immune Evasion
… cancer cells growing under lipid peroxidation or immune pressure. Cancer cells rewire their metabolism and rely on endogenous antioxidants to mitigate lethal oxidative damage to lipids. However, the metabolic processes which modulate the response to lipid peroxidation are poorly defined. Using …
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The Role of NKT Cells in Immune Evasion of Liver Metastases Arising from Intraocular Tumors
Uveal melanoma (UM) is the most common intraocular tumor in adults and liver metastasis is the leading cause of death in UM patients. We have previously shown that NKT cell-deficient mice develop significantly fewer liver metastases from intraocular melanomas than do wild-type (WT) mice. Here, we …
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Fas ligand expression and tumour immune evasion; the role of prostaglandin E2 and the EP1 receptor
… tumours develop multiple mechanisms to evade the immune system and suppress the anti-tumour immune response. Upregulation of Fas Ligand (FasL/CD95L) expression may represent one such mechanism. FasL is a member of the tumour necrosis factor superfamily that triggers apoptotic cell death following …
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Functional and Mechanistic Analysis of Protein Degradation by Human Cytomegalovirus to Uncover Viral Immune Evasion Mechanisms
… that is controlled by a multifaceted host immune response. However, immunocompromised patients, including transplant recipients and those with acquired immunodeficiency syndrome, are at a high risk of HCMV-associated morbidity and mortality. HCMV is also the most prevalent infectious cause …
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Functional Genomic Studies of Cancer Immune Evasion Using In Vitro and In Vivo CRISPR/Cas9 Genetic Screens
… have shed light on the mechanisms of cancer immune evasion. An accumulation of data in recent years has identified several immune checkpoints, whose expression by cancer cells allows them to evade anti-cancer immune responses. The great potential of these findings is highlighted by the recent …
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Understanding the function and structure of herpes simplex virus type 1 pUL55, a novel immune evasion protein
… protein, which we hypothesised to be an innate immune modulator with similar functions to ICP0. ICP0 exhibits E3 ubiquitin ligase activity and is known to stimulate proteasomal degradation of several host proteins in HSV-1 infected cells. Multiple studies to date have used the *dl*1403 mutant …
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The Cx3Cl1-Cx3Cr1 Chemokine Axis Contributes to Tumor Immune Evasion and Its Blockade Enhances Responses to Anti-Pd-1 Immunotherapy
… While CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration, the mechanisms employed by this axis on these cells to mediate immune suppression remain poorly understood. Here, we explore the immune evasion strategies implemented by this axis and …
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Functional and Structural Characterisation of Spy0136, a Novel Group A Streptococcal Virulence Factor
… a potential involvement of this protein in immune evasion mechanisms. This binding was shown to be glycan-dependent for C1s, C3, and C5. Functional analysis of Spy0136 in host immune evasion revealed that the protein inhibits complement-mediated haemolysis of erythrocytes. Moreover, …
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Immunity to Leishmania mexicana parasite
… consists of two stages which involve different immune evasion mechanisms: promastigote and amastigote. Understanding parasitic interactions with host cells and developing a protective vaccine could improve the management and treatment of the disease.
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