Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Immune Escape"”.
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Role of Nitric Oxide-Signalling in Hypoxia-Induced Immune Escape in Cancer
… is the acquired ability of tumour cells to escape immune-mediated lysis. A potential mechanism by which tumour cells avoid immune destruction involves the shedding of MHC Class I Chain-Related Protein A (MICA), a Natural Killer (NK) cell-activating ligand, from the tumour cell membrane. …
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A discrete-time waning immunity model for the spread of an immune escape pathogen
… of waning immunity models for the spread of an immune escape (antigenically evolving) pathogen, such as the Omicron lineage of SARS-CoV-2, and investigates the possibility of such models in generating sustained or relatively large amplitudes of damped oscillations in infections. The classic …
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Dissecting Human Antibody Responses Against Influenza A Viruses And Antigenic Changes That Facilitate Immune Escape
… pre-existing antibodies, allowing the virus to escape population immunity in a process known as antigenic drift. Due to antigenic drift, individuals can be repeatedly infected by antigenically distinct influenza strains over the course of their life. Antigenic drift undermines the effectiveness …
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Tumor immune escape in allogeneic stem cell transplantation: Releasing the brake on graft-versus-tumor immunity
Contains fulltext : 101020.pdf (Publisher’s version ) (Open Access)
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HIV-1 Immune Escape and Neutralizing Antibodies : Solid Phase Proteoliposomes Containing HIV-1 Envelope Glycoproteins as Antigens and Immunogens and HIV-1 Core Envelope Glycoproteins Deficient in T-Helper Epitopes
… vaccines has been frustrated by many viral immune escape mechanisms. Trimeric envelope glycoprotein formulations hold promise to overcome limitations of monomeric envelope glycoproteins as immunogens. The generation of native, trimeric envelope glycoprotein complexes, however, remains a …
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Development and characterization of immunogenic genetically engineered mouse models of pancreatic cancer
Insights into mechanisms of immune escape have fueled the clinical success of immunotherapy in many cancers. However, pancreatic cancer has remained largely refractory to checkpoint immunotherapy. To uncover mechanisms of immune escape, we have characterized two preclinical models of immunogenic …
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Evolution of adaptive immune response from acute to chronic phase of hepatitis C virus infection
… replication during HCV infection. HCV evades the immune system by rapid viral evolution affording escape from immune selection pressure including at MHC-I restricted epitopes. However, some CTL epitopes remain conserved well past the time of establishment of chronic infection, implying additional …
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Modelling the Evolution of HIV-1 Protein-Coding Sequences with Particular focus on the early stages of Infection
… could render the virus more sensitive to host immune responses, are of particular interest for vaccine studies. However, sequence samples from the earliest phase of HIV infection are scarce, and inferences about the nature of the infecting virus and its evolution during the course of early …
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INTRA-TUMORAL INFILTRATION OF GZMKHIGH CD8+ T EFFECTOR MEMORY CELLS IS ASSOCIATED WITH POOR CLINICAL OUTCOME IN NON-METASTATIC COLORECTAL CANCER.
… subtype that likely generate disparate immune responses. The heterogeneity in the immune cell response to CRC highlights the need to develop novel immune diagnostics that could predict the risk of disease relapse and devise a secondary strategy to address that risk. The purpose of this …
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Population dynamics of infectious disease and pathogen evolution: modelling vaccine escape
… focussing on the selection pressure for immune escape. We study the qualitative patterns of this escape pressure — as a function of the vaccination coverage — and the epidemiological impact thereof, taking analytical approaches wherever possible. Chapter 2 varies the balance of the …
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Using Tumour Evolution to Understand the Epigenetic and Transcriptional Adaptations of Cancer to Host Immunity
… development whereby tumours evolve to avoid the immune system. The relevance of immunoediting in carcinogenesis, metastasis and immunotherapy resistance makes understanding the mechanisms of immunoediting essential in informing cancer therapy and prevention. Previous work on immunoediting has …
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HIGH-THROUGHPUT PROFILING OF INNATE IMMUNE CELLS TO UNVEIL TUMOR ESCAPE MECHANISMS IN MATCHED COLORECTAL CANCER AND LIVER METASTASES
… tumor types largely unresponsive to immune checkpoint (IC) therapies. Indeed, MSS/MSI-L tumors display "immune cold" microenvironments dominated by immunosuppressive mechanisms, which severely constrain treatment options. This unmet clinical need highlights the importance of …
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Wastewater-Based Genomic Epidemiology
… variants with increased transmissibility or immune escape, which drove successive waves of infection and reinfection. Genomic surveillance has become a cornerstone of pathogen monitoring, but clinical sequencing remains expensive, logistically demanding and biased by non-random testing. …
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Atr-Mediated Cd47 and Pd-L1 Upregulation Restricts Radiotherapy-Induced Immune Priming and Abscopal Responses In Colorectal Cancer
… are extremely rare, and the post-irradiation immune escape mechanisms in CRC remain elusive. We report that CRC cells utilize a common DNA repair signaling pathway — ATR/Chk1/STAT3 — to upregulate both CD47 and PD-L1 in response to radiotherapy, which through engagement of SIRPα and PD-1 …
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Learning from pre-pandemic data to design and test future-proof therapeutics
… pandemic preparedness relies on predicting immune-evasive viral mutations to enable early detection of variants of concern and design vaccines and therapeutics that are resilient to future viral evolution. However, current strategies for viral evolution prediction are not available early in …
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EPIGENETIC MODIFICATIONS REGULATING LIVER HOMEOSTASIS AND TUMORIGENESIS
… by the selection of mutations able to induce immune escape. Conversely, the abrogation of all the cBAF complexes, targeting both Arid1A and Arid1B subunits, led to synthetic lethality in a couple of weeks. Moreover, loss of all the Arid1 proteins caused a strong effect on transcriptional …
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Untersuchung zur Funktion von Cathepsin B in der durch zytotoxische T-Zellen vermittelten Lyse von Tumorzellen
… durch CTL ausgesetzt sind, Cathepsin B als einen Immune escape -Mechanismus nutzen.
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Compartmental Hepatitis B Virus (HBV) Evolution, Replication and Infectivity in vivo and ex vivo
… under the influence of NA therapy or host immune pressure (i.e., fulminant hepatitis B). The study on HBV replication and genetic evolution in PBMC, liver and plasma of CHB patients under NA therapy revealed the HBV evolution varied between three compartments both before and after …
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Intratumoral B and T cell receptors: reconstruction and analysis
… organism. In cancer, abnormal cells manage to escape the immune system and grow uncontrollably. In this sense, cancer can be considered as an oversight of the immune system, as immune escape is a defining feature of clinically detectable cancers. The role of the immune system in fighting cancer …
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