Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Immune Checkpoint Molecules"”.
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INSIGHTS ON THE CROSSTALK BETWEEN THE IMMUNE SYSTEMAND CANCER: IMMUNE CHECKPOINT MOLECULES AND LYMPHOIDPOPULATIONS ASSESSMENT IN CANINE ROUND CELL TUMORS
The crosstalk between the immune system and cancer represents a fundamental aspect of oncology, since a better understanding of disease mechanisms could lead to the development of novel therapeutic strategies. This PhD project focused on three main topics: (1) the expression and prognostic role of …
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Investigating the inhibitory effects of secreted proteins on macrophage in glioblastoma
… microenvironment of glioblastoma contributes to immune suppression and inhibition of T cell activity through secreted immuno-suppressive proteins and cytokines, dysfunction of immune cells and upregulation of immune checkpoint molecules. Macrophages are the most populous non neoplastic cells in …
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Molecular basis of immunotolerance in canine neoplasia
… highly immunogenic neoplasm, the function of the immune system is hampered by the expression of immune checkpoint molecules by the cancer cells. In contrast, soft tissue sarcomas are poorly immunogenic, as Tumor infiltrating Lymphocytes are lacking, or when present they are usually at the …
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Étude de l’expression et du rôle du ligand du co-stimulateur inductible des cellules T (ICOSL) dans les ostéoclastes humains
… in the bone microenvironment with bone cells and immune cells present in the adjacent bone marrow. Osteoclasts, which degrade the bone matrix, express costimulatory molecules on their surface, like antigen-presenting cells, which enable them to interact with immune and cancer cells, exerting an …
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Immune Checkpoint Molecule Expression in Canine Lymphoma and Canine Reactive Lymphoid Hyperplasia
… treatments. Targeted immunotherapy using checkpoint molecule blockade of PD-1 and PD-L1 shows promise for various types of human cancer, including relapsed/refractory lymphoma; however, little is known regarding the role of these checkpoint molecules in canine lymphoma. Objectives: To …
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Identification of tumour microenvironment-derived signals that modulate the development and functionality of MDSCs
… Suppressor Cells (MDSCs) are a heterogeneous immune population found within the tumour microenvironment (TME). We sought to explore the potential role of microenvironment components on the suppressive behaviour, development and maintenance of MDSCs, focusing mainly on the role of the …
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THE ROLE OF CD4+ T MEMORY SUBSETS IN HIV INFECTION: IMMUNE RESPONSE IN PEOPLE WITH HIV AND LATENCY ESTABLISHMENT
… make them pivotal for maintaining durable immune memory and controlling persistent infections. In the context of vaccination, the induction of vaccine-specific TSCM is a key determinant of long-term protection. In the context of human immunodeficiency virus (HIV), CD4+ TSCM, serve as target …