Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Immune Checkpoint Inhibition"”.
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Determining stromal evolution in response to immune checkpoint inhibition
Directing the immune system to recognise and eliminate developing tumours has been hypothesised for over a century, yet only recently has this concept translated to the clinic with the discovery of immune checkpoint inhibitors (ICIs) which reactivate anti-tumour T cells. However, their rapid …
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Imaging Biomarkers of Response to Immune Checkpoint Inhibition in Melanoma
Immune checkpoint inhibition using monoclonal antibodies targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed cell death receptor-1 (PD-1) to enhance cytotoxic T-lymphocyte response against tumours has been used in the management of several malignancies including metastatic melanoma. …
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DESIGNING ANTI-PDL1 ANTIBODY CONJUGATED POLYMERIC COACERVATES AS A NOVEL “NANO-IMMUNOTHERAPY” AGAINST HEPATOCELLULAR CARCINOMA
… death and conjugated anti-PDL1 antibodies for immune checkpoint inhibition against murine hepatomas was thus designed. Several crucial insights have been gleaned which provide a roadmap for the improvement of future designs of nano-immunotherapies not only for a more robust and stable delivery …
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Investigating the Role of Hippo/Warts Signaling in Sarcomatoid Renal Cell Carcinoma
… epithelia. Lats1/2 mutant tumors respond to immune checkpoint inhibition (ICI), as is seen in some human sRCCs. Bioinformatic analysis reveals an enrichment of serum response factor (Srf) targets amongst genes upregulated following Lats1/2 deletion. Ablating Srf in the Lats mutant background …
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DELINEATING GUT-MEDIATED RESPONSE AMONG MELANOMA PATIENTS UNDERGOING ANTI-PD1 IMMUNOTHERAPY
The advent of immune checkpoint inhibition therapy markedly improved outcome for melanoma. However, response remains heterogeneous, with about half of the patients being refractory or developing relapse. Meanwhile, current knowledge on the causal link between the gut microbiota and immunotherapy …
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Development of monoclonal antibodies targeting T cell coinhibitory proteins TIM-3 and TIM-4
Immune checkpoint inhibition (ICI) therapy uses antibodies to block checkpoint proteins from binding with their partner proteins to help overcome dysfunctional T cells and promote the recognition and elimination of tumour cells. The exploration of novel immune checkpoint targets, like T cell …
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The Efficacy of Immunotherapy in Preventing Liver Cancer and the Role of Metabolic Zonation in Its Development
… two questions about HCC. First, we asked if immune checkpoint inhibition could prevent tumorigenesis in a chemically-induced mouse model of HCC. We found that initiation of anti-PD-1 immunotherapy prior to tumorigenesis could prevent up to 46% of liver tumors. This reduction in tumor burden …
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Modelling pancreatic cancer in vivo with patient derived organoids & humanised mouse models for the investigation of immunotherapeutic treatment response
… preclinical models are heavily reliant on murine immune compartments or reconstitution with an allogeneic human immune system (HIS), and thus do not represent the immunophenotypic variations between patients. In this dissertation I outlined the development of a novel preclinical model of human …
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Discovery of Anti-CD47 Peptides for Cancer Immunotherapy and CD47-mimicking Peptides That Inhibit Phagocytic Clearance of Nanoparticles
… as a standard pillar of cancer treatment. Immune checkpoint inhibitors that are currently available target the adaptive immune system, generating T-cell antitumor responses. As critical innate immune cells, macrophages play important roles in homeostasis, preventing pathogen invasion, …
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Potential of metabolic MRI to address unmet clinical needs in localised renal cancer.
… biology of the most aggressive region (e.g. immune-checkpoint inhibition rather than anti-angiogenetic agent as I propose in the FHd-RCC report). 2. Chapter 3: here I have addressed the unmet clinical need for more accurate renal tumour subtype differentiation. Building on previously reported …
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Modeling of Cns Cancer With A Focus On The Immune Component
… developed, in particular with regard to the immune component. The works contained in this thesis look at craniopharyngioma, glioblastoma, and several forms of brain metastasis. While some attention is given to the tumor cells themselves, as well as the patient setting which these studies …