Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 439 for “"Immune Cell"”.
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Polyunsaturated fatty acids and immune cell functions
… with baseline. It also significantly decreased cell surface expression of CD36+, CD54+ and CD62L+ on monocytes. In contrast, there was no association between LA-rich corn oil and these adhesion molecules and chemokines suggesting that GLA and/or its metabolites are affecting the chemokines and …
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Functional Asymmetry of The Immune Cell Plasma Membrane
<p>Mammalian cells maintain a distinct disparity in lipid composition between the two leaflets of the bilayer of the plasma membrane. This compositional asymmetry is most prominent for phosphatidylserine (PS), a negatively charged lipid that is found almost exclusively on the cytoplasmic (inner) …
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Imaging innate immune cell behaviour in lymphoid organs
Innate immune cells generate the early host response to infection and tissue injury. Neutrophils are rapidly recruited from circulation to inflammatory tissues for pathogen killing. Type 2 innate lymphoid cells (ILC2s) mediate early responses to helminths and allergens via cytokine production. …
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Investigating Tumour-Immune Cell Interactions in Paediatric Malignancies
… of interactions between the patient’s immune system and tumour. We hypothesised that biological properties of tumours that do not respond to immunotherapy can be detected prior to treatment and serve as biomarkers for patient selection. Furthermore, we hypothesise that tumour cell …
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Immune cell alterations in mouse models of prostate cancer
Numerous studies have demonstrated that tumour cells have the ability to alter immune function to create an immune suppressed environment. This allows tumour cells to escape immune surveillance and consequently the tumour can progress. Dendritic and T cells have critical roles in immune activation …
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Development of 89Zirconium-PET Tracers for Immune Cell Imaging
The use of cell-based therapies as a living drug have gained considerable attention for the treatment of a range of conditions such as genetic diseases, autoimmune disorders and cancer. The emergence of genetically engineered T cells expressing chimeric antigen receptors (CAR T-cells), together …
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Alterations in endometrial immune cell populations affect endometrial cell functions
… unclear. Research now shows evidence that the immune system has a pivotal role in endometriosis development as well as the related infertility. Among other immune cells, the T-helper lymphocytes accumulate in the normal endometrium during the mid- to late-secretory phase of the menstrual cycle …
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Metabolic control of immune cell fate by hypoxia-inducible factors
… for life and is a major determinant of mammalian cell fate. Vital systems are driven by the activity of oxygen-dependent enzymes within fundamental processes, such as cellular metabolism and gene transcription. The hypoxia-inducible factors (HIFs), which are regulated by oxygen-sensing …
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Tumor cell-immune cell interaction: A lethal two way street
… ligand expression upon activation through the T-cell receptor and induced apoptosis in Fas+, LSA tumor cells using the FasL-based pathway. However, LSA and EL-4 tumor cells constitutively expressed Fas ligand and killed Fas+ PE-9 CTLs and Fas+, but not Fas-negative (Fas-) activated T cells and …
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Single-cell Analysis of Structural and Immune Cell Interactions in Periodontitis
… insight into inflammatory pathways, single-cell RNA sequencing (scRNA-seq) enables detailed characterization of cell-type–specific responses and coordinated interactions within the periodontal microenvironment. OBJECTIVE: This study aimed to compare the transcriptional landscapes of …
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Rgg2/Rgg3 Quorum Sensing in Streptococcus pyogenes and Innate Immune Cell Responses
The immune system and microbial pathogens work against each other in many ways resulting in a never-ending dance. This thesis investigates the relationship between macrophages, a type of innate immune cell, and Streptococcus pyogenes, an important human pathogen. In Chapter 2 of this thesis, it is …
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Gestational trophoblastic disease - clinical prediction and exploration of the immune cell landscape
Contains fulltext : 292282.pdf (Publisher’s version ) (Open Access)
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Investigation of the role of BACE1 in adipocyte and immune cell function
… to obesity. This was shown by a reduction in immune cell infiltration, in particular macrophages, in the white adipose tissue (WAT) and liver accompanied by reduced levels of pro-inflammatory, and increased levels of anti-inflammatory, cytokines within the WAT. This led to the hypothesis that …
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Route of Nutrient Administration Alters Intestinal Immune Cell Composition in Neonatal Piglets
… and disaccharidase activity and alters systemic immune function. The impact of TPN on intestinal immune cell composition in neonates has been poorly characterized. Therefore, the central objective of this doctoral research was to determine the effects of TPN on intestinal immune cell composition …
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Uncovering the Immune Cell Landscape of Melanoma using Multiplex Immunohistochemistry and Computational Analysis
Contains fulltext : 283469.pdf (Publisher’s version ) (Open Access)
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Engineering extracellular vesicles and immune cell homing materials for next generation cancer immunotherapy
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Epithelial and immune cell dynamics in non-traditional models of mammary postnatal development
… epithelial bilayer of luminal and myoepithelial cells. The specific contribution of each distinct epithelial compartment to mammary postnatal development and the mammary microenvironment remains to be elucidated. The present study aims to exploit the ovine and rabbit mammary gland to interrogate …
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Recessive and rare variant effects on common diseases and the immune cell transcriptome
… in G&H with rare, putative LoFs affecting immune genes, for single-cell RNA-sequencing (scRNAseq) of peripheral blood mononuclear cells (PBMCs). Cell-type-specific LoF effects on transcription have yet to be studied at scale, and in my thesis I discuss the three phases to building this …
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The Effect of the Conceptus on Endometrial Angiogenesis and Immune Cell Populations During Implantation
… factors produced by the conceptus that target cells of the endometrium during this period of time when the endometrium is undergoing decidualization. This review focuses on some of the approaches that have been used in the past and what has been learned about the effect of the conceptus on the …
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