Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 5984 for “"Immune"”.
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Leveraging Innate Immune Sensors to Generate Durable Anti-Glioma Adaptive Immune Responses
… T cell effector infiltration but is dominated by immune suppressive microglia, macrophages, and myeloid-derived suppresser cells. These innate immune cells display impaired phagocytosis and antigen presentation and are inadequate for triggering the subsequent immune activating signals needed for …
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The impact of maternal immune activation on pig muscle development and postnatal immune function
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-04-12 without embargo terms
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Behavioral analysis of piglets exposed to a second immune challenge following maternal immune activation
The combined effects of maternal immune activation (MIA) and a second immune challenge later in life on pig behavior have not been studied. Deciphering these effects is particularly relevant in diseases that can have pronounced effects during gestation, such as porcine reproductive and respiratory …
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Adaptive Immune Responses to Vaccination Against SARS-CoV-2 in Individuals with Immune Dysregulation
… utilised novel mRNA technology to produce an immune response against the viral spike protein. The efficacy of these vaccines was key to control the pandemic and beyond this, vital for the protection of individuals at high risk from disease. The pace of the expeditious approval and subsequent …
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Immune Dysfunction in Cystic Fibrosis
… environment of the lungs or innate to CF immune cells itself, leukocytes were isolated from peripheral blood and stimulated with LPS and compared to healthy donors. Our hypothesis is that there will be an increase in cytokine expression in blood leukocytes as well, with a further increase …
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Scaling in the immune system
How different is the immune system in a human from that of a mouse? Do pathogens replicate at the same rate in different species? Answers to these questions have impact on human health since multi-host pathogens that jump from animals to humans affect millions worldwide. It is not known how rates …
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Immune Priming in A. Mellifera
Trans-generational immune priming (TgIP) is the transfer of maternal immune experience to progeny, producing offspring pathogen resistance and ultimately survival from infections. In colony-forming insects like the honey bee Apis mellifera, TgIP would yield a form of lasting immunity benefiting …
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GP96 and the immune response
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 2001.
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Modulation of macrophage and epithelial cell immune defences by probiotic bacteria: immune stimulation versus suppression
… play a fundamental role in driving muco-sal immune responses. These include, tolerance, associated with an M2-, regulatory macrophage phenotype and inflammatory activation with an M1-like phenotype. The cross-link between mucosal tolerance and inflammatory cytokine suppression, and …
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Inflammatory Breast Cancer: The Immune Perspective
… is known about the role of inflammation or immune mediators in IBC. Therefore, we analyzed blood samples from IBC patients and non-IBC patients, as well as healthy donor controls to establish an IBC-specific profile of peripheral blood leukocyte phenotype and function of T cells and …
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Genetic Exploration of Hereditary Immune Diseases
<p>An autoimmune disease is a condition arising from an abnormal immune response to a normal body part. There are at least 80 types of autoimmune diseases, rheumatoid arthritis and systemic sclerosis are two of them. My study focuses on these two diseases. Our hypothesis is that mutated genes lead …
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The immune response in Q fever.
Contains fulltext : 145305.pdf (Publisher’s version ) (Open Access)
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Immune Mediators of Murine Lyme Arthritis
Lyme disease is the most common vector-borne disease in both the United States and Europe; however, its pathogenesis is incompletely understood. The studies described in this thesis aid in the elucidation of mechanisms regulating murine Lyme arthritis and may suggest mechanisms by which human Lyme …
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Novel innate immune functions of saliva
The innate immune system in humans has succeeded in developing numerous mechanisms against the injurious effects of bacteria, along with their toxins as a result of several thousand years of co-evolution. The oral mucosal surface represents such a unique environment, where despite being constantly …
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Characterisation of TAPBPR in immune cells
… lines (B-lymphocytes and monocytes) and primary immune cells were identified. Intriguingly, interactomic studies revealed the association of TAPBPR with non-classical MHC-I molecules. Taking specific interest in HLA-F, an enigmatic MHC-I molecule, the association was confirmed through …
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Immune reactions in acute viral hepatitis
viii, 122 leaves
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Senescence and the Innate Immune System
… Senescent cells are removed by the innate immune system, including natural killer (NK) cells, during normal embryonic development and healthy wound healing. Since eradication of senescent cells in mice leads to resistance against age-related disorders and functional restoration, one …
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Immune reconstitution post bone marrow transplantation
… of this project were therefore: to document the immune reconstitution following T-cell depleted bone marrow and peripheral blood stem cell transplantation and to compare this with the recovery following autologous grafts. to document the cell surface expression of CD95 in an attempt to comment on …
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