Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Immature B cell"”.
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The Role of Foxo Transcription Factors in B Cell Development and Activation
… system depends on a diverse, self tolerant B cell repertoire. Mature B cells distributed throughout secondary lymphoid organs respond to antigenic stimuli by dividing and differentiating into plasma cells and other effector cell types. Signaling from the B cell receptor (BCR) plays a critical …
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Proteins mediating somatic hypermutation and class switch recombination at the immunoglobulin locus
Summary Antibodies are produced by B cells before antigen contact. A given B cell synthesizes antibodies of one specificity only. However, the large number of B lymphocytes allows for a large diversity, which stands ready to meet the antigenic universe. Upon contact with the cognate antigen, the B …
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Untersuchungen zur CD40 induzierten Expression von A1 in B-Lymphozyten der Maus
Stimulation von unreifen B-Lymphozyten der Maus über den Antigenrezeptor führt zu Wachstumsstopp und Apoptose. Eine gleichzeitige Stimulation über CD40 bewirkt die Aufrechterhaltung der Proliferation und schützt die Zellen vor programmiertem Zelltod. In der vorliegenden Arbeit konnte gezeigt …
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PKB/Akt : a critical regulator of lymphocyte, development and function
… kinase, is highly involved in the regulation of cellular proliferation and survival. To characterize PKB’s function in lymphocyte development and activation, transgenic (tg) mice that express a membrane targeted constitutively active form of PKBa (myr PKB) in T and B cells were analysed. …
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B cell signalling in mechanisms of central and peripheral tolerance
… system to prevent autoimmunity. Hence during B cell development, a number of central and peripheral developmental checkpoints ensure the deletion of self-reactive B cells and selection of tolerant B cells. For example, antigen-driven ligation of the B cell receptor (BCR) on immature B cells …