Global ETD Search
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Showing 1 to 19 of 19 for “"Imipramine"”.
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The Imipramine Binding Site: Effects of Aging, Ovarian Hormones, Adrenal Hormones, and Chronic Antidepressant Treatment
Binding sites for the antidepressant imipramine have been described in the brain and blood platelets of several species of animals, including rats and humans. Decreased levels of imipramine binding sites are found in depressed patients when compared to controls.
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An evaluation of a proposed animal model of depression: Effect on adult behavior and response to imipramine in three tests
Antidepressant (AD) administration to developing rats produces behavioral alterations in adulthood. The similarity between these behavioral alterations and symptoms of depressive disorder suggested that juvenile antidepressant administration may be useful as an animal model of depression.
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A Post-Treatment Evaluation of the Combined Effects of Imipramine Pharmacotherapy and Brief Psychotherapy in the Treatment of Childhood Anxiety Disorders
… methodologies. The treatment program integrated Imipramine pharmacotherapy and brief psychotherapy. The participants' nuclear and extended family histories were examined in terms of the occurrence of psychopathology and endemic transactional patterns. The examination of family patterns utilized …
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The Role of Chromatin Remodeling in Hippocampus in Depression and Antidepressant Action
… and chronic treatment with the antidepressants imipramine and electroconvulsive seizure (ECS). Chromatin modifications and transcriptional changes were assayed in one gene in particular, the brain-derived neurotrophic factor (BDNF). BDNF is alternatively spliced to generate several mRNA …
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Minimal Brain Dysfunction with Hyperactivity: a Comparison of the Behavioral and Cognitive Effects of Pharmacological and Behavioral Treatments
… stimulant (methylphenidate) and antidepressant (imipramine) drugs in the short-term, clinical treatment of minimal brain dysfunction. Twenty-nine boys, ranging in age from 6 through 12 years, with the diagnosis of minimal brain dysfunction with hyperactivity, were randomly assigned to three …
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The Role of CREB in Social Isolation and Natural Reward Behavior
… by chronic but not acute administration of imipramine. In addition, aspects of social isolation can be mimicked in non-isolated animals by inhibition of CREB in the nucleus accumbens and certain deficits in isolated animals can be reversed by wildtype overexpression of CREB. However, other …
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Measurement Of Anhedonia In The Chick Anxiety-Depression Model
… administration of vehicle, 10 or 15 mg/kg Imipramine prior to exposure to the isolation apparatus folloby testing in the straight alley maze. Both 10 and 15 mg/kg Imipramine were shown to alleviate the onset of behavioral despair in the isolation test. The 15 mg/kg Imipramine dose also …
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ANTIDEPRESSANT EFFECTS OF THE NTS1 AGONIST PD149163 IN THE FORCED SWIM TEST
… PD149163 and the tricyclic antidepressant drug imipramine on immobility in the forced swim test and on locomotor activity in an open field in mice. PD149163 decreased the total time spent immobile at doses of 0.1 mg/kg and 1.0 mg/kg, without increasing overall locomotor behavior in the open …
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Monoaminergic Regulation of MeCP2 Phosphorylation in Mouse Models of Psychiatric Disease
… increase in social interaction following chronic imipramine treatment, the KI mice fail to show a behavioral response to chronic treatment. These data suggest that pMeCP2 may be implicated in the antidepressant action of chronic imipramine. Finally, investigation of the brain regions in which …
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Identification Of A Treatment-Resistant, Ketamine-Sensitive Genetic Line In The Chick Anxiety-Depression Model
… were administered the tricyclic antidepressant imipramine (0-20 mg/kg), the selective serotonin reuptake inhibitor (SSRI) fluoxetine (0-10 mg/kg), the tetracyclic antidepressant maprotiline (0-10 mg/kg), the glutamate receptor antagonist ketamine (0-15 mg/kg), or vehicle (physiological saline) …
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The Impact of Efficacious Treatments for Major Depressive Disorder on Remission Rates of Specific Symptoms: A Re-Analysis of the Treatment of Depression Collaborative Research Program
… 158 adults with MDD randomized to CBT, IPT, imipramine or placebo. We statistically derived 4 factors from the baseline Hamilton Depression Rating Scale. We hypothesized that the rate of remission of somatic factors (sleep and appetite) would be most rapid in the group receiving imipramine …
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Pharmacological Reversal of Cognitive Bias in The Chick Anxiety-Depression Continuum Model
… to ensure that drug treatments, clonidine and imipramine, do not substantially influence cognitive decision making to natural and ambiguous appetitive and aversive stimulus cues in the social treatment condition. Experiment 1 consisted of three socially tested groups (previous studies have …
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Examining Hippocampal Reelin Expression and Neural Plasticity in an Animal Model of Depression
… corticosterone (CORT), and the antidepressant imipramine, influence reelin expression in the proliferative region of the hippocampus. In addition we determined whether changes in reelin expression are associated with alterations in neurogenesis and behavioral measures of depression. Results …
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The role of the C. elegans transcription factor LIN-11 in cell fate specification
… lin-11 mutant animals were exposed to serotonin, imipramine or nicotine. These drugs are able to induce egglaying in wild type and ablated wild type animals. Ablated hermaphrodites homozygous for a lin-11 mutation exposed to the drug treatments were not able to lay eggs. Therefore, the abnormal …
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Quantitative assessment of the pharmacotherapy of biopolar disorder and schizophrenia
… to 7). The relapse risk ratio for lithium versus imipramine was 0.62 (95% CI 0.46 to 0.84) and the NNT was 4 (951% Cl 3 to 7), The combination of lithium and imipramine was no more effective than lithium alone. The risk of relapse was greater with lithium alone than with the lithium-divalproate …
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The Impact of Sunlight Variation on Depressive Symptoms Following Treatment for Major Depressive Disorder
… behavior therapy (CBT), interpersonal therapy, imipramine, or placebo administered for 16 weeks. Depressive symptom severity, recovery status, and categorical ratings of symptomatology were then measured on four occasions during the 18-month follow-up period. Treatment site-specific sunlight …
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Cationic amphiphilic drug-induced autophagosome accumulation is due to autophagosome sequestration within vimentin intermediate filament networks resulting in prolonged autophagosome half-life
… <p>amphiphilic drugs (CADs) U18666A, imipramine and clozapine caused</p> <p>lysosomal non-esterified cholesterol and autophagosome accumulation.</p> <p>Measurement of LC3-II conversion in the presence of lysosomal inhibitors</p> <p>bafilomycin A1 and NH4Cl, degradation of long-lived …
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Early environments and neurobehavioural programming: Therapeutic actions of antidepressants. Neurobehavioural programming during development.
… were administered vehicle or an antidepressant (imipramine 15mg/kg; or sertraline 10mg/kg) once daily until postnatal day 10. We assessed maternal Porsolt activity, nurturance (ABN, L/G, nest building) and anxiety-like behaviour in the elevated plus maze (EPM). Representative offspring of each …
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Inhibition of extracellular vesicle release enhances cancer chemotherapy and inhibition of outer membrane vesicle release sensitises bacteria to antibiotic and bacteriophage therapy
… EV inhibitors Bisindolylmaleimide-I, EGTA, Imipramine, Pantethine and Y27632 inhibited OMV release significantly. The role of EV inhibitors on antibiotic therapy was then further explored. The disc diffusion method and Minimum Inhibitory Concentration (MIC) was used to determine whether OMV …