Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Imipenem"”.
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Pseudomonas aeruginosa OprD-Family Porins Facilitate Imipenem Translocation Resulting in AmpC β-Lactamase Induction Contributing to the Effectiveness of Imipenem/Relebactam
… relebactam in combination with the carbapenem imipenem has restored susceptibility in some isolates, yet the mechanism remains unknown. Imipenem resistance has been tied to the depletion of the outer membrane porin, OprD and overproduction of AmpC chromosomal β-lactamase. It is not known how …
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IN VITRO ΑΝΑΠΤΥΞΗ ΑΝΤΟΧΗΣ ΠΡΟΤΥΠΟΥ ΣΤΕΛΕΧΟΥΣ PSEUDOMONAS AERUGINOSA ΣΤΟ ΙΜΙΡΕΝΕΜ ΚΑΙ ΙΔΙΟΤΗΤΕΣ ΑΥΤΟΥ
… AERUGINOSA (IR) WAS "ADAPTED" IN VITRO TO IMIPENEM BY SERIAL TRANSFERS IN BROTH CONTAINING INCREASING CONCENTRATIONS OF ANTIBIOTIC AND UP TO 32MG/ML. 30 SERIAL SUBCULTURES OF THE RESISTANT PROGENY (IR-RES) IN ANTIBIOTIC FREE SOLID MEDIA RESULTED IN A PROGENY (IR-REV) WHICH WAS STILL …
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Molecular Mechanisms of Antibacterial Resistance Among Pseudomonas aeruginosa: Multi-Drug Efflux Pumps and Their Interactions with Other Resistance Mechanisms
… addition, a drug combination of fluoroquinolone-imipenem was explored to prevent the emergence of resistance during therapy by efflux and other chromosomal mechanisms. Contrary to previous reports in the literature, four of the well characterized efflux pumps, mexAB-oprM, mexCD-opri, mexEF-oprN, …
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Metronidazole resistance in clinical Bacteroides fragilis isolates from Groote Schuur Hospital, Cape Town, South Africa
… showed that 8% were highly resistant to imipenem and cefoxitin and 65% to tetracycline. All strains were sensitive to clindamycin. Two strains, B. fragilis GSH8 and GSH15 were Mtz resistant and strain GSH15 showed multidrug resistance to metronidazole, imipenem, cefoxitin and …
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Studies of the nature of Burkholderia cepacia in cystic fibrosis
… was particularly effective in the hydrolysis of imipenem. Meropenem, biapenem, cephaloridine, ceftazidime, benzylpenicillin, ampicillin and carbenicillin were hydrolysed at a lower rate. An unusual inhibition profile was noted. Inhibition by the metal ion chelators ethylene diamine tetra acetic …
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The postantibiotic effect of the carbapenem antibiotics on gram-negative bacteria
… evaluate the in vitro PAE of three carbapenems; imipenem, meropenem and biapenem on Gram-negative bacteria under reproducible laboratory conditions that partially mimicked those occurring in vivo. The effects on carbapenem PAE of the method of antimicrobial removal, concentration, exposure …
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The microbiological causes of chronic osteomyelitis at the University Teaching Hospital,Lusaka
… showed highest sensitivity to ciprofloxacin and imipenem. Chronic osteomyelitis was common in children (median age 7.5 years) and in patients of low socioeconomic status. CONCLUSION: Staphylococcus aureus is the commonest cause of chronic osteomyelitis at the University Teaching Hospital.
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Perfil de resistência aos antimicrobianos frente à pseudomonas aeruginosa isoladas de afecções oftálmicas em diversas espécies: revisão sistemática
… nofloxacin and gatifloxacin) and to Imipenem. In the isolates were observed resistance of the 82,9% to chloramphenicol, proving not to be effective against Pseudomonas aeruginosa. This is the prove that the empirical use of this antibiotic should be better evaluated due to the rapid …
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Ocorrência de Staphylococcus sp. em ambiente hospitalar, caracterização de superfícies e adesão de Staphylococcus aureus em sondas nasoenterais de poliuretano e silicone
… (30 µg), ceftazidima-CAZ (30 µg), imipenem-IMP (10 µg), oxacilina- OXA (1 µg), sultamicilina ampicilina e sulbactam-APS (10/10 µg) e vancomicina-VAN (30 µg). Corpos-de-provas das sondas de poliuretano e silicone foram submetidos à análise de tensão de ruptura e estiramento …
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Investigation of the prevalence of antibiotic resistant bacteria and their genes in wastewater
… genes. Penicillin, ampicillin, meropenem and imipenem traces were determined in domestic wastewater and Bacillus cereus isolates were identified. CTX M, TEM and SHV resistant genes were detected. These genes are commonly found in water and are implicated in numerous diseases such as …
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Fieber und Neutropenie bei krebskranken Kindern - prognostische Faktoren und Therapie
… Therapieerfolg einer initialen Monotherapie mit Imipenem/Cilastat zur Behandlung von Kindern mit Fieber und Chemotherapie-bedingter Neutropenie zu untersuchen und mit dem Therapieerfolg einer initialen Therapie mit einer Ceftazidim/Teicoplanin Kombination zu vergleichen. In insgesamt 106 …
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Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
… between ceftobiprole and both meropenem and imipenem. Vancomycin, balofloxacin, and floxuridine showed weak synergy. A similar antagonistic effect of mupirocin on ceftobiprole was also observed in other studies showing that it led to β-lactam resistance. We also performed a high-throughput …
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Charakterisierung und Antibiotika-Resistenzprofil von Shiga Toxin-produzierenden Escherichia coli Isolaten von Patienten und Ausscheidern
… Cefotaxim, Ceftazidim, Cefotiam und Imipenem, die Aminoglykoside Gentamicin und Streptomycin, die Gyrasehemmer Ofloxacin und Ciprofloxacin sowie Tetracyclin, Chlorampenicol und die Sulfamethoxazol/Trimethoprim-Kombination Cotrimoxazol. Alle E. coli O157 Stämme, die von Patienten mit …
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Artificial Intelligence Applications for Optimizing Population and Clinical Drug Decision-Making Processes
… cost-effectiveness analysis of cefiderocol and imipenem/cilastatin indicated for cUTI using MS Excel, the software program TreeAge, and ChatGPT4. The third and last study evaluated ChatGPT4’s validity and reliability in identifying and classifying adverse drug events of fluoroquinolone …
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Prevalência e perfil de susceptibilidade aos antibióticos de patógenos em uroculturas de crianças
… pneumoniae. No sulfametoxazol trimetoprima e no imipenem foram encontradas as menores e as mais elevadas respectivas taxas de sensibilidade, em relação aos patógenos pesquisados. Discussão e conclusões: a frequência de ITU em meninos no primeiro ano de vida foi 1.83 vezes maior do que em meninas …
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Detection and characterisation of carbapenem-resistant gram-negative bacilli infections in Ghana
… of CR isolates showed complete resistance to imipenem, meropenem and ertapenem at ≥32 μg/ml, of which 24.3% were found in Pseudomonas aeruginosa isolates and 18.9% in Acinetobacter baumannii isolates. In all, no KPC-1 and IMP-1 genes were detected. Carbapenemase genes identified were blaNDM-1 …
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Mobilome and antibiotic resistance in Acinetobacter baumannii
… (such as ceftazidime) and carbapenems (such as imipenem and meropenem) represent important treatment options for infections caused by this microorganism. Nevertheless, the number of strains resistant to these antibiotics has been increasing during the last decade. The ability to capture, …
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Pseudomonas aeruginosa: estudo epidemiológico e da ação do óxido nítrico sobre biofilmes de amostras mucoides de pacientes com fibrose cística
… eficazes contra a P. aeruginosa foram Amicacina, Imipenem, Meropenem e Aztreonam. Biofilmes de amostras mucóides da P. aeruginosa são muito mais complexos se comparados aos das amostras não-mucóides. No primeiro caso, as bactérias se agregam em estruturas que lembram teias de aranha que se fixam …
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Caracterización de mecanismos de resistencia a carbapenémicos, integrones y tipificación molecular en cepas de Pseudomonas aeruginosa de diferentes orígenes
… (85%) y el hallazgo de dos cepas resistentes a imipenem en una misma muestra de pimiento. El análisis de los mecanismos de resistencia a carbapenémicos, la presencia de integrones y la tipificación molecular de los aislados fueron también objetivos de esta tesis. Se observó la ausencia de …
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Characterization of β-lactamases and Porins in Uropathogenic E. coli
… to the carbapenems meropenem, ertapenem and imipenem. (3) KPC protein levels could not explain variability in the β-lactam MICs of the KPC producers. (4) Porin aberrations were associated with carbapenem non-susceptibility in five isolates: three non-carbapenemase producers and two …
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