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Showing 1 to 4 of 4 for “"Imidazopyridines"”.
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Exploration of Transition Metal Catalyzed C−C and C−N Bond Formation to Access Synthetically Elusive Small Molecules
… intermediates, as they readily provide access to imidazopyridines and similar heterocyclic systems. The direct synthesis of N-substituted-3-amino-4-halopyridines is problematic, as reductive aminations and base promoted alkylations are difficult in these systems. A high yielding …
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Targeting the Colchicine Binding Site on Tubulin to Overcome Multidrug Resistance and Anticancer Efficacy of Selective Survivin Inhibitors
… several structural scaffolds including indolyl-imidazopyridines (DJ95 and DJ101), VERU-111 analogs with a modified indole moiety (10ab and 10bb) or 3,4,5-trimethoxyphenyl moiety (13f), and heterocyclic pyrimidines (4a, 6a, 5a, and 5b). We demonstrated the cytotoxic potency of these compounds …
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Antimalarial benzimidazoles and related structures incorporating an intramolecular hydrogen bonding motif: medicinal chemistry and mechanistic studies
… two classes of compounds, benzimidazoles and imidazopyridines, incorporating an intramolecular hydrogen bonding (IMHB) motif, were explored for their antimalarial potential. These two chemotypes were selected on account of their privileged nature due to their capacity to interact with various …
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Ruthenium Hydride Catalyzed Silylvinylation of Alkynes
<p>The intermolecular ruthenium hydride catalyzed coupling of internal alkynes with subsequent insertion of olefin acceptors is described. This approach utilizes a vinyl silicon tether to provide complete regiocontrol, a stereoselective anti-exo-dig cyclization which affords a tetrasubstituted …