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Showing 1 to 10 of 10 for “"Imidazolidinone"”.
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Antiviral Agents: 3,5-Disubstituted 1,2,4-Oxadiazole Derivatives and Novel Peptidomimetics Containing Hydroxyethyl Isostere and Imidazolidinone Structures
… new class of peptidomimetics derived from both imidazolidinones and hydroxyethylene isosteres is described herein. The key step of their synthesis is the opening of a fused ring aziridine with amino acids or small peptides to form an oxazolidinone, followed by rearrangement to the target …
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Observations on the Mode of Action of 2-Imidazolidinone, a Female Sterilant of the Adult House Fly Musca Domestica L. (Diptera: Muscidae)
Made available in DSpace on 2014-12-09T20:27:17Z (GMT). No. of bitstreams: 1 6507182.pdf: 3237679 bytes, checksum: 60a48845708e03142529944824205a64 (MD5) Previous issue date: 1965
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Imidazolidinones in amine catalysis
… perceived shortcomings. In Chapter 2, a novel imidazolidinone containing an α-electron withdrawing group is evaluated as an asymmetric catalyst for Diels-Alder cycloaddition reactions. A substrate and reaction scope is presented and the conformational preference of the imidazolidinone is probed …
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The use of chiral auxiliaries in the synthesis of chemically and biologically important chiral compunds
… importance have been synthesised using imidazolidinone and Evans' oxazolidinone chiral auxiliaries (CA). The thesis comprises two parts, which were carried out at the Universities of Cape Town, RSA and University of Michigan in the USA. In part 1, carried out in the Chemistry Department …
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Chiral acyl radicals generated by visible light enable stereoselective access to 3,3-disubstituted oxindoles: application toward the synthesis of (–)- and (+)-physovenine
… This work outlines the development of a novel imidazolidinone-derived acyl radical, generated under photoredox catalysis, and its application toward the stereoselective synthesis of 3,3- disubstituted oxindoles via an additional-cyclisation cascade sequence to acrylamide precursors. 6 oxindoles …
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Studies in Synthesis and Organocatalysis: (i) The Design and Synthesis of Novel Electron Deficient Dienes and their Application in the First Enamine Activated Organocatalytic 1,6-Conjugate Addition. (ii) The Development of a New Organocatalytic Methodology through the Combination of DNA-Based Catalysis and Organocatalysis
… of a novel achiral DNA-intercalating imidazolidinone was realized in high yield (40% yield over 4 steps). Several synthetic routes to the intercalating imidazolidinone were explored. The catalyst was found to still retain the ability to generate a reactive iminium ion and participate …
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Gold(I) and Platinum(II)-Catalyzed Hydrofunctionalization of Allenes and Alkenes with Carbon and Nitrogen Nucleophiles
… hydroamination of 1-alkenes with 1-methyl-2-imidazolidinone was expanded to include additional 1-alkenes functionalized with carboxylic acid derivatives. However, a nucleophile screen failed to identify nucleophiles other than cyclic ureas and 2-oxazolidinone that efficiently undergo …
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New methodology for the synthesis of chiral, non-racemic a-tertiary amine centres: application to the synthesis of the marine alkaloid lepadiformine
… alkylation of an auxiliary-malonate, in which an imidazolidinone auxiliary provided excellent facial selectivities in the alkylation in conjunction with KHMDS as the base. Five derivatives were generated in high yields (>85 %) and selectivities (dr >95:5). Extension of the methodology to generate …
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AMIDYL RADICALS IN LIGHT PROMOTED REACTIONS
… of amidyl radicals to aldehydes employing an imidazolidinone organocatalyst to promote the selectivity of the transformation. Moreover, we report also the development of the flow process for this transformation. Chapter 2.2 concerns the development and the study of a new class of amidyl …
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Selenium redox-catalyzed alkene syn-difunctionalization
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01