Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Imidazoles"”.
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The preparation and reactions of some imidazoles
Thesis (M.A.)--University of Kansas, Chemistry, 1920. ; Includes bibliographical references.
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Reactividad de imidazoles y triazoles coordinados a fragmentos metálicos: formación de enlaces C-C o M-C
… fundamentalmente la desprotonación de N- alquilimidazoles o N- alquiltriazoles coordinados a fragmentos organometálicos catiónicos. Estos complejos metálicos podrían considerarse análogos a las sales de azolio correspondientes (imidazolio o triazolio) y su desprotonación da lugar a especies muy …
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The Photochemical Cyclisation of N-Styryl Compounds Produced During an Investigation into the Reactions of Imidazoles with Epoxides
Please see Thesis for the abstract.
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Investigation of bioactive scaffolds as antimicrobials
… from previous projects, 1,5-disubstituted imidazoles and ascididemin scaffolds were identified as lead compounds, prompting further investigation. An SAR investigation of 1,5-disubstituted imidazoles afforded 71 novel second-generation 1,5-disubtsituted imidazole compounds. Biological …
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Recent advances in copper- and palladium-catalyzed carbon-heteroatom and carbon-carbon bond-formation
… with a variety of nucleophiles, including (benz)imidazoles, oxindoles, 2-, 3- and 4-hydroxypyridines, anilines, and aliphatic, benzylic, allylic and propargylic alcohols. In many cases, catalyst optimization and ligand structure are discussed and evaluated. Where applicable, the palladiumand …
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Towards a fragment approach to haemozoin inhibiting antimalarials : exploration of coordination and π-stacking interactions with Fe(III)PPIX by spectroscopy and synthesis
… Coordination of a series of pyridines, imidazoles, amines and phenolates with Fe(III)PPIX, and n-stacking interactions of these compounds with protoporphyrin IX (PPIX) and Fe(III)PPIX were measured in 40% (v/v) aq. DMSO by spectrophotometric titration.
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Kinetics and Mechanism of the Catalysis of the Decomposition of Hydrogen Peroxide by Schiff Base Complexes of Copper(II).
… and imidazole or methyl substituted imidazoles, B, which form monomeric CuSALAD.B<sub>2</sub> complexes, in aqueous ethanol solvent. Freezing point depression and vapor pressure lowering studies were carried out to confirm the dimeric nature of the [CuSALAD]<sub>2</sub>.H<sub>2</sub>O …
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Studies in the synthesis of pyrimidines, pyrazoles, and pyrazolo pyrimidines. New syntheses of 1, 3 and 5 substituted pyrazolo [3, 4-d] pyrimidines, including glycosides related to naturally occurring pyrimidines, imidazoles, purines and their nucleoside derivatives.
Some compounds, analogous to those found in naturally occurring systems, are found to possess chemotherapeutic activity. Some, in the form of their nucleoside or nucleotide derivatives, are valuable antimetabolites in that they may block normal RNA or DNA polymerisation, or may be incorporated into …
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Palladium-catalyzed C-N cross-coupling and application to the synthesis of delayed singlet emitters for OLED development
… methods provide efficient access to N-arylated imidazoles and pyrazoles in moderate to excellent yields. In Chapter 3, a series of novel triptycene-based compounds were synthesized using a palladium-catalyzed C-N, C-C, C-N cross-coupling sequence. Experimental results suggest that this series of …
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Nickel-catalyzed asymmetric cross-couplings of secondary alkyl electrophiles and photoinduced, copper-catalyzed C-N couplings
… variety of N-heterocycles, such as indoles, benzimidazoles, imidazoles, and carbazoles, undergo Ullmann couplings under mild conditions (room temperature) with an inexpensive catalyst (Cul, without an added ligand).
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Analogues of bredinin: Synthesis of 5-hydroxyimidazoles from acyclic precursors
Compared to 1-substituted-5-aminoimidazoles relatively few 1-substituted-5-hydroxyimidazoles have been reported; however, an interesting 1-substituted-5-hydroxyimidazole is the immunosuppressive agent bredinin, which shows antiviral, antimalarial, antitumour and antiarthritic activities. Bredinin …
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A mechanistic assessment of novel anticancer drugs targeting the metastatic cascade and tumour vascularisation.
… of efflux transporters. Unlike CA-4, imidazoles are chemically stable and do not undergo isomerisation into the inactive trans-configuration of the CA-4 stilbene motiv. Additionally, they are not recognised by MDR-transporters of cancer cell lines that are refractory to CA-4. In in …
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Carbon−Hydrogen Bond Functionalization using Removable Monodentate Directing Groups
… coupling of sp2 C−H bonds with pyrazoles, imidazoles, and sulfonamides. Reactions proceed in fluorinated alcohol solvents at elevated temperatures and require use of 1.3−3 equiv of copper(II) acetate. This appears to be the first method for copper-promoted C−H/N−H coupling directed by a …
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Myoglobin Microsperes and Metalloporphyrin -Peptide Complexes
… the cyclic peptide complexes ligate both imidazoles cooperatively to the heme, producing only a low spin complex. Electrochemical measurements of the E1/2 of the FeIII(coproporphyrin-I) complexes of these peptides are all a fairly low potentials, ranging from -215 to -252 mV vs. NHE at pH …
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Apertura de sulfamidatos cíclicos con nucleófilos nitrogenados
… frente a diferentes aminas aromáticas, como imidazoles y pirazol, obteniendo los productos de apertura del sulfamidato con buenos rendimientos. Por último, se completó el estudio utilizando como nucleófilos diversas piridinas y N-alquilimidazoles, llegando a los correspondientes productos de …
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Study of Bis-Imidazol-2-Ylidines as Ligands for Transition Metal Catalyzed Coupling Reactions
… were developed. In this study the aryl imidazoles were prepared from the corresponding phenol and carbonyldiimidazole. Subsequent N-alkylation then furnished the Nheterocyclic carbenes in high yield. Novel unsymmetrical N-heterocyclic carbenes with aryl and benzylic side groups have been …
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Synthetic coenzymes for in vitro selection of DNA enzymes.
… suggest a catalytic role for the coenzyme imidazoles. In conclusion, we have demonstrated that combinatorial selection techniques can be used to select for coenzyme-dependent deoxyribozymes. This convenient methodology provides the opportunity to utilize the power of synthetic organic …
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Discovery of Novel Tubulin Polymerization Inhibitors and Survivin Inhibitors as Potential Anticancer Agents
… previously reported a set of 2-aryl-4-benzoyl- imidazoles (ABI) derivatives with potent anti-proliferative activity against melanoma cells and xenografts. A new series of 4-aryl-2-benzoyl-imidazoles were designed and synthesized after further optimization of the ABI series. The new scaffold …
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ELECTROCHEMICAL ORGANIC TRANSFORMATIONS: FROM THE DEVELOPMENT OF ENANTIOSELECTIVE STRATEGIES TO CONTINUOUS-FLOW METHODOLOGIES
… such as protected resorcinols and electron-rich imidazoles, while electron-poor arenes and easily oxidized heterocycles like indoles undergo competitive anodic degradation.
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Excited state intramolecular proton transfer (ESIPT) to nitrogen in heterocyclic compounds
… counterparts (HPBT and HPBO) and the related imidazoles. - The compounds of the pyridine group are related to the basic structure of 2-(2'-hydroxyphenyl)-pyridine (HPP). Structural variations involve benzo fusion (quinolines) and addition of a 3,3' bridge. A complementary compound is the well …
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