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Showing 1 to 2 of 2 for “"Imidazo[1,2-a]pyridine"”.
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Exploiting Chemical Libraries to Identify and Characterize Novel Bioactives with Efficacy Against Pathogenic Candida Species
… modified to generate substituted analogues and imidazo[1,2-a]pyridine bio-isosters to improve metabolic stability. I identified four analogues with improved stability that retained anti-Candida bioactivity. Furthermore, all four analogues selectively inhibited C. albicans Yck2 over the human CK1 …
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Computational and synthetic approaches in the design and development of chemical probes for estrogen receptor function
… Correspondingly, we describe the development of imidazo[1,2-a]pyridine ligands to probe the importance of the core scaffold structure in ligand binding affinity. Computational analysis of ligand and receptor structures has led to the identification of the interaction between their respective …