Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"Imaging probe"”.
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Responsive, multimodal imaging agents for MRI: advancing the detection of metals and oxidized species implicated in neurodegenerative disorders
… successful development of responsive, multimodal imaging agents required a bottom-up approach starting with the nature of the iron oxide nanoparticles. Thee relaxivity of the nanoparticles was found to be dependent on the total anisotropy of the particles themselves, which is in turn a function of …
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Forward viewing OCT endomicroscopy
A forward viewing fiber optic-based imaging probe device was designed and constructed for use with ultrahigh speed optical coherence tomography in the human gastrointestinal tract. The light source was a MEMS-VCSEL at 1300 nm wavelength running at 300 kHz sweep rate, giving an effective A-line rate …
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Novel Devices for Terahertz Wave Imaging, Wave-guiding and Sensing
… terahertz waves for broadband near-field imaging, wave-guiding (invisible space), and sensing (resonator), are presented in this thesis. We developed the original working concepts of each device, and demonstrated the prototype experimentally in our lab. The working concepts of physics were …
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Design Of A Dynamic Focusing Microscope Objective For Oct Imaging
… Coherence Tomography (OCT) is a novel optical imaging technique that has assumed significant importance in bio-medical imaging in the last two decades because it is non-invasive and provides accurate, high resolution images of three dimensional cross-sections of body tissue, exceeding the …
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Nuclear magnetic resonance microscopy and diffusion
… with a home-built high resolution microscopy imaging probe. It is one of the most stable microimaging system designed and fully equipped for microscopic fMRI study. This work is an advancement of using MRI to study fundamental neuron science and cell signal pathways in vivo. NMR Microscopy of …
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Large-scale imaging of endothelial calcium from inside intact atreries
… model. This thesis describes a novel microscopic imaging system that enables direct visualisation of the endothelium from within the lumen of intact and pressurised arteries. The system incorporates a custom-built, side-viewing imaging probe (consisting of a gradient-index relay lens and an …
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Exciton Dynamics in DNA-Chromophore Assemblies
… materials for light harvesting, computing, and imaging. Such applications require control over the spatiotemporal evolution of excited states. Natural light harvesting systems achieve the required control through precise molecular placement; however, it has been challenging to emulate …
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New technologies for optical coherence microscopy
… from unacceptable false negative rates. Optical imaging technology that provides real-time, high-resolution imaging of human tissue in vivo with resolution at or near that of histopathology may significantly improve clinicians' capabilities to identify malignancies at curable stages. The ability …
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The Development of Peptide Analogues as Potential Fluorescent and PET Imaging Probes.
Molecular imaging is a non-invasive way to diagnose disease. Molecular imaging probes consist of a targeting entity that has a high affinity for a biological target and a signaling source for external detection. Multimodality imaging combines the advantages of different imaging modalities, at the …
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Endoscopic optical coherence tomography for clinical studies in the gastrointestinal tract
… cross-sectional and three dimensional imaging by measuring the echo time delay of backscattered light. OCT imaging is performed using low-coherence interferometry. With the development of Fourier domain detection techniques and fiber-optic based OCT endoscopes, high speed internal body …
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Targeting the Tumor Stroma Using a Monoclonal Antibody Platform Technology
… new and innovative approaches to treat mCRPC. Imaging is a crucial aspect of mCRPC clinical management used for the detection of recurrent or distant disease. The development of new therapies is also dependent on accurate imaging modalities for patient staging and evaluating treatment response. …
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Fluorinated Nanoparticles: A Novel Technology Platform for Multimodal Biomedical Imaging Applications
… in microbubble contrast agents for ultrasound imaging, positron sources for PET imaging, and as an imaging probe in 19F MRI. Additionally, fluorinated organic compounds generate a high ionization yield of fluorine in secondary ion mass spectrometry (SIMS), which is gaining recognition as an in …
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Measurements of small ice crystals in arctic cirrus: observations from the Indirect and Semi-Direct Aerosol Campaign (ISDAC)
… and Aerosol Spectrometer (CAS), a Cloud Droplet Probe (CDP), a Forward Scattering Spectrometer Probe (FSSP), and a two-dimensional stereo probe (2DS) were compared as functions of the concentrations of crystals with D > 100 μm measured by a Cloud Imaging Probe (CIP) and two-dimensional stereo …
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Swept source optical coherence microscopy for pathological assessment of cancerous tissues
… OCM offers a suitable alternative to confocal imaging by providing enhanced contrast due to the additional coherence gate to the inherent confocal gate, increasing the field of view and imaging depth, and eliminating the need of external contrast agents. In the past, development of OCT systems …
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Anti-inflammatory drugs for modulation of host response to biomaterials and application in diabetes therapy
… Firstly, we developed a new non-invasive in vivo imaging technique to study the activity of early immune cells in the host response to implanted biomaterials. A fluorescent imaging probe (Prosense680*, Perkin Elmer) activatable by cathepsins, a class of inflammatory proteases secreted from immune …
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Novel approaches to MRI of glioma
… contributes to a very poor prognosis. Current imaging of glioma is insufficient for a thorough diagnosis, therapy assessment and prognosis prediction. Moreover, refined and more sophisticated imaging technique could help in furthering our knowledge of gliomas. In order to facilitate …
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The use of gamma distributions to quantify the dependence of cloud particle size distributions in hurricanes on cloud and environmental conditions
… Analyses project with in-situ cloud probes installed on the NASA DC-8 are used to identify snow and graupel particles through measures of particle morphology, and then to define SDs of snow and graupel, and of all ice hydrometeors combined. These SDs are then fit to gamma functions to …
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Design, Synthesis and Development of Transporter Targeting Agents For Image-Guided Therapy and Drug Delivery
… count density ratios up to 5 at 4 hour imaging. Both <sup>99m</sup>Tc-labeled agents showed decreased tumor uptake after paclitaxel treatment. Immunohistochemistry analysis demonstrated that the uptake of <sup>99m</sup>Tc-N4amG was correlated with Ki-67 expression. Both …