Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"Imaging biomarkers"”.
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Imaging biomarkers for Duchenne muscular dystrophy
… patients. We propose the use of image-based biomarkers with suitable machine learning algorithms instead. We find that force-controlled (precise acquisition at a certain force) and force-correlated (acquisition over a force sweep) ultrasound helps to reduce variability in the imaging process. …
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Advanced imaging biomarkers in age-related macular degeneration
Η ηλικιακή εκφύλιση της ωχράς κηλίδας, είναι μία κύρια αιτία σημαντικής μείωσης της όρασης παγκοσμίως, ενώ η επίπτωση της εκτιμάται ότι θα αυξηθεί σημαντικά. Η αναγνώριση πρώιμων βιοδεικτών που θα σημάνουν την αυξημένη πιθανότητα μετάπτωσης από πρώιμα σε πιο προχωρημένα στάδια της νόσου, που …
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Validation of photoacoustic imaging biomarkers in cancer biology
… the photoacoustic effect, photoacoustic imaging (PAI) holds significant potential to elucidate these dynamics, but to fulfil this potential, a need for a thorough technical and biological validation arises. This thesis presents technical validation of PAI systems, which builds confidence …
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Novel imaging biomarkers and resection strategies in pancreatic cancer
Contains fulltext : 312719.pdf (Publisher’s version ) (Open Access)
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Magnetic Resonance Imaging Biomarkers of Renal Structure and Function
… are essential, especially noninvasive diagnostic imaging. While other imaging modalities (ultrasound and x-ray/CT) have their unique advantages and disadvantages, MRI has superb soft tissue contrast without ionizing radiation. More importantly, there is a richness of contrast mechanisms in MRI …
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Diffusion Tensor Imaging Biomarkers of Brain Development and Disease
… Recently, diffusion tensor magnetic resonance imaging has emerged as a powerful tool for brain atlasing; however, its utility is hindered by image resolution and signal limitations. These limitations can be overcome by imaging fixed ex-vivo specimens stained with MRI contrast agents, a …
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Imaging Biomarkers of Response to Immune Checkpoint Inhibition in Melanoma
… approach. The development of non-invasive imaging methods and imaging biomarkers of response to immune checkpoint inhibitors could therefore provide important diagnostic and prognostic information. This project builds on existing technologies in Cambridge to develop structural and …
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Statistical Methods For The Analysis And Development Of Quantitative Imaging Biomarkers
The field of neuroimaging statistics is concerned with elucidating meaningful conclusions from high-dimensional imaging objects, often in the form of single-dimensioned summary statistics. Ideally, these summaries should provide interpretable biomarker measurements that can guide patient diagnoses …
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Model-based quantitative combinatorial optical microscopy for extracting clinical imaging biomarkers
… noninvasive, high-resolution biomedical optical imaging techniques based on unique, yet complementary, contrast mechanisms have emerged. While each imaging modality is able to elucidate certain properties of the particular sample under study, an integrated approach in which all modalities are …
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Graph Theory and Dynamic Programming Framework for Automated Segmentation of Ophthalmic Imaging Biomarkers
… Earlier and faster detection of ophthalmic imaging biomarkers also leads to optimal treatment and improved vision recovery. While modern optical imaging technologies such as optical coherence tomography (OCT) and adaptive optics (AO) have facilitated in vivo visualization of the eye at the …
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Exploring Radiomics and Unveiling Novel Qualitative Imaging Biomarkers for Glioma Diagnosis in Dogs
… and analyze quantitative features from medical imaging modalities such as Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Positron Emission Tomography (PET), ultrasound (US) and digital radiographs (DX). By extracting pixel/voxel-level data, followed by standardization and feature …
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Radiobiological mechanisms and novel imaging biomarkers in metastatic prostate cancer treated with radium-223
Prostate cancer is the most commonly diagnosed form of disease and the most frequent cancer among men in the UK. The vast majority of metastatic prostate cancer patients who initially respond to Androgen deprivation therapy (ADT), will eventually progress to castration-resistant prostate cancer …
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Digitally quantified neuropathological correlates of structural and functional imaging biomarkers in progressive supranuclear palsy
Neuroimaging measures are increasingly useful as *in vivo* biomarkers for differential diagnosis in neurodegenerative tauopathies. However, the relationship between imaging changes and neuropathology requires more thorough validation and beyond Alzheimer’s disease. In tauopathies, tau is the key …
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Investigation of Radiation Injury In The Esophagus From Definitive Chemoradiation Therapy Using Novel Imaging Biomarkers
… esophagus by first developing <em>in-vivo</em> imaging biomarkers of radiation-response in the esophagus using 4-dimensional computed tomography (4DCT) and <sup>18</sup>fluorodeoxyglucose positron emission tomography (FDG-PET), separately. These imaging biomarkers were then compare with …
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Improving breast cancer risk assessment with image-based deep learning models
… information about breast tissue using imaging biomarkers such as density scores. However, these imaging biomarkers are limited in that they suffer from variability in radiologists' assessments and they reduce the rich information contained in the image down to a single number. In this …
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Methods for the Prediction of Osteoradionecrosis resulting from Head and Neck Cancer Radiation Therapy
… method to achieve this goal is by evaluating imaging biomarkers associated with ORN development. With appropriate imaging biomarkers, HNC treatment can be optimized to reduce the prevalence of ORN and allow for earlier ORN detection.</p> <p>In this dissertation, several imaging biomarkers were …
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Exploring neurodegeneration in Ataxia-Telangiectasia
… precise disease phenotyping, and metabolic and imaging biomarkers limits the progress of developing curative treatments and successful clinical trials for this disease. This study focuses on trial readiness and exploring the neurodegenerative process in A-T. I have focused on the development of …
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Non-invasive diagnosis of non-alcoholic fatty liver disease.
… analysis of liver magnetic resonance images as biomarkers for NASH and fibrosis detection by investigating patients with biopsy-proven NAFLD who underwent magnetic resonance protocols using 1.5T General Electric or Philips devices. Two imaging biomarkers (NASHMRI and FibroMRI) were developed, …
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Radiomic Analysis of Sonograms for the Detection of Tendon Damage
… Hence, there is a critical need to establish biomarkers to assist in early detection of tendinopathy in at-risk populations such as athletes. One set of imaging biomarkers can be generated using radiomics. This technique extracts numerical values from medical images, such as those captured …
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Energy failure following traumatic brain injury: Potential mechanisms and impact of normobaric hyperoxia
… aimed to examine the utility of diffusion tensor imaging and whole-brain proton MR spectroscopy (WB 1H MRS) as imaging biomarkers to investigate normobaric hyperoxia as a therapeutic option following traumatic brain injury (TBI). Using ([18F] FMISO PET evidence of tissue hypoxia consistent with …
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