Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Imaging biomarker"”.
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Quantitative Dwi As An Early Imaging Biomarker of The Response to Chemoradiation In Esophageal Cancer
… ultrasound, re-biopsy, and morphologic imaging are insufficient for this purpose. During nCRT, morphologic changes in tumors are often preceded by changes in the tumor biology. Diffusion Weighed Imaging (DWI) is an MRI modality which is sensitive to microscopic motion of water molecules …
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INTEGRIN ALPHAVBETA3 AS THERAPEUTIC TARGET AND IMAGING BIOMARKER FOR VASCULAR ENDOTHELIAL CELLS AND CANCER EPITHELIAL CELLS
… are in fact the ideal candidate for optical imaging because they are not susceptible to photobleaching and may be functionalized in several ways. During this work the small library of cyclic RGD peptidomimetics alone or conjugated with imaging probes or nanoparticles was screened. It was …
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Methodological Development of A Multi-Parametric Quantitative Imaging Biomarker Framework For Assessing Treatment Response With Mri
<p>Quantitative imaging biomarkers (QIBs) are increasingly being incorporated into early phase clinical trials as a means of non-invasively assessing the spatially heterogeneous treatment response to anticancer therapies, particularly as indicators for early response. MR QIBs are derived from the …
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The Rat as a Translational Model of Neurotrauma: Primary Somatosensory Input and Imaging Biomarker Validation Following Spinal Cord and Peripheral Nerve Injuries
… to help validate and evaluate advanced dMRI biomarkers of PNI. Our long long-term goal is to use dMRI to quantify nerve injury and recovery to aid clinical decision making and aid prognostication following PNI. We found that rats display a similar response to primates and are suitable …
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Quantitative Non-Contrast Perfusion Measurements Using Arterial Spin Labeled MRI: Evaluation of Therapy Response in Brain Tumors and Technical Advancements in Kidneys
… change in size becomes evident. Quantitative imaging techniques can identify these early effects, providing a valuable window of opportunity to effectively manage cancer treatments. Notably, angiogenesis, a key biological process that promotes aberrant tumor neovascularization, is emerging as …
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Exploring Radiomics and Unveiling Novel Qualitative Imaging Biomarkers for Glioma Diagnosis in Dogs
… and analyze quantitative features from medical imaging modalities such as Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Positron Emission Tomography (PET), ultrasound (US) and digital radiographs (DX). By extracting pixel/voxel-level data, followed by standardization and feature …
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In vivo Knee Kinematics and Cartilage Recovery of Noncontact Anterior Cruciate Ligament Injuries
… using bone bruises present on magnetic resonance imaging, and 2) to assess cartilage recovery time as a potential imaging biomarker of osteoarthritis in ACL injured subjects. In the first aim, two common bone bruise patterns were determined and used to quantitatively determine the injury position …
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The perioperative setting as a platform for breast cancer biomarker development
… breast cancer. The identification of predictive biomarkers of response to systemic therapy is of great research interest, as this may allow treatment to be tailored to the individual. Pathologic complete response (pCR), the absence of residual invasive carcinoma in the breast or axillary lymph …
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EXAMINING BACKGROUND PARENCHYMAL ENHANCEMENT AS A NOVEL BIOMARKER FOR BREAST CANCER RISK IN BLACK WOMEN
… screening with breast magnetic resonance imaging (MRI) or ultrasound, as breast density—the proportion of fibroglandular to fatty tissue—can obscure tumors on mammography. Additionally, reast density is a moderate-to-strong risk factor, showing a clear dose-response relationship with …
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ARTIFICIAL INTELLIGENCE FOR DETECTION AND QUANTIFICATION OF BREAST ARTERIAL CALCIFICATIONS ON MAMMOGRAMS AS A BIOMARKER OF CARDIOVASCULAR DISEASE
… as one of the most promising women-specific biomarkers: BAC are localized Mönckeberg sclerosis expression involving within the tunica media of breast arteries and detectable as parallel line opacities on about 13% of routine mammograms. They have been shown to be associated with an elevated …
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Magnetic Resonance Spectroscopy Imaging of 2-Hydroxyglutarate in Brain Tumors at 3T and 7T In Vivo
… is a significant breakthrough in neuro-oncology imaging. 2HG is the first imaging biomarker that is specific to a genetic mutation in gliomas, making the diagnosis of IDH mutant gliomas possible without biopsy. 2HG also has a significant predictive value with respect to the stage and survival in …
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Improving Quantitative Treatment Response Monitoring With Deformable Image Registration
Quantitative imaging with 18F-FDG PET/CT has the potential to provide an in vivo assessment of response to radiotherapy (RT). However, comparing tissue tracer uptake in longitudinal studies is often confounded by variations in patient setup and potential treatment induced gross anatomic changes. …
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Hyperpolarized Xenon-129 Magnetic Resonance Imaging of Functional Lung Microstructure
… contrast agent for lung magnetic resonance imaging (MRI), which upon inhalation follows the functional pathway of oxygen in the lung by dissolving into lung tissue structures and entering the blood stream. HXe MRI therefore provides unique opportunities for functional lung imaging of gas …
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Postmortem image analysis of the human brain to characterize Alzheimer's disease and related dementias
… to detect and diagnose a patient using in vivo imaging biomarkers. These biomarkers have been sensitive in detecting structural changes, such as cortical thickness and volumetry, during the early stages of AD. However, their potential as an imaging biomarker is limited due to their lack of …
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Atherosclerotic inflammation imaging using somatostatin receptor-2 positron emission tomography
… atherosclerotic plaque progression and rupture. Imaging vascular inflammation affords a valuable marker of atherosclerotic disease activity to reveal important mechanistic insights for CVD research, to quantify early anti-inflammatory effects of new atherosclerosis drugs, and, ultimately, to help …
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Discovery of new biomarkers of mild cognitive impairment and Alzheimer's disease risk in buccal cells using laser scanning cytometry
… the principles of flow cytometry, quantitative imaging and immunohistochemistry with high-content, multi-color fluorescence analysis, and can be used to identify specific cells in a heterogeneous population as well as scoring unique molecular events within them. This study aimed at investigating …
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Magnetic Resonance Assessment of Aortic Stiffness in Diabetes and Cardiovascular Disease
… in estimating vessel length. Magnetic resonance imaging (MRI) is an established clinical cardiovascular imaging modality which like ultrasound, has the advantage of being non-invasive and non-ionising. Whilst not typically part of a clinical cardiovascular examination, MRI sequences can be …
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Clinical Translation of Optoacoustic Imaging in Breast Cancer
Optoacoustic (OA) imaging is an emerging low-cost hybrid imaging investigation/technique currently in clinical feasibility studies for breast cancer diagnosis and staging. The technique applies pulsed light to the tissue of interest where molecules absorb the light photons and generate acoustic …
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Quantitative Magnetic Resonance Imaging and Analysis of Articular Cartilage and Osteoarthritis
… search for a sensitive osteoarthritis (OA) imaging biomarker able to detect early, pre-morphological alterations in cartilage composition. Determining the compositional recovery pattern of cartilage following acute joint loading could potentially present a more sensitive biomarker for …
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Advanced Magnetic Resonance Imaging of Osteoarthritis
… utility of magnetic resonance (MR) quantitative imaging biomarkers (QIBs) of knee osteoarthritis (OA) for rapid assessment of treatment efficacy in experimental medicine studies. The development of treatments able to modify disease in OA is hampered by an inability to evaluate treatment response …
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