Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Imaging Genetics"”.
-
Imaging genetics evidence for the neurodevelopmental model of schizophrenia
This thesis applies a wide range of imaging genetics methods to disentangle the complex genetic relationship between brain structural phenotypes and schizophrenia. Chapter 1 reviews current imaging and genetic evidence for the neurodevelopmental model of schizophrenia. The neurodevelopmental model …
-
PARALLEL INDEPENDENT COMPONENT ANALYSIS WITH REFERENCE FOR IMAGING GENETICS: A SEMI-BLIND MULTIVARIATE APPROACH
<p>Imaging genetics is an emerging field dedicated to the study of genetic underpinnings of brain structure and function. Over the last decade, brain imaging techniques such as magnetic resonance imaging (MRI) have been increasingly applied to measure morphometry, task-based function and …
-
Integration of multi-omic data and neuroimaging characteristics in studying brain related diseases
… was supported by advancements in medical imaging and genotyping technologies that result in rich data production in the field of imaging genetics and radiogenomics. Studies in these fields have taken different designs and directions from genomewide associations to studying the complex …
-
Multimodal data analysis applied to a medical setting
… histopathology images in the context of imaging-genetics is demonstrated by its superior correlations with gene expressions. These findings affirm the utility of CCA for joint phenotype-genotype analysis of cancer, and the importance of capturing spatial features at multiple scales.
-
The Measure and Meaning of Structural Similarity in the Brain
The concept of similarity has recently emerged as a central and often-overlooked organizing principle of brain network structure. At the same time, recent advances in structural MRI analytics have enabled large-scale mapping of anatomical similarity within individual brains. However, key questions …
-
Genetic association of high-dimensional traits
Over the past ten years, more than 4,000 genome-wide association studies (GWAS) have helped to shed light on the genetic architecture of complex traits and diseases. In recent years, phenotyping of the samples has often gone beyond single traits and it has become common to record multi- to …
-
Decoding the Notch signal: investigating dynamics of transcription directed by Notch responsive enhancers
Information from developmental signalling pathways must be accurately decoded to generate transcriptional outcomes. Notch is an evolutionarily conserved signalling pathway, which, despite its apparent simplicity, regulates very different processes across tissues and developmental contexts. After …