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Showing 1 to 20 of 412 for “"Il-10"”.
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IL -10 gene therapy for the treatment of pulmonary inflammation
Interleukin-10 (IL-10) is an anti-inflammatory cytokine that plays an important regulatory role in inflammatory diseases. The overall goal of this research is to investigate the potential therapeutic effect of IL-10 gene therapy for the treatment of pulmonary inflammation and to develop appropriate …
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TFR Cells Suppress Gut Commensal-Specific IgA Via IL-10
… Treg-derived suppressive pathways such as IL-10. To test this, we employed a food allergy model by priming WT controls (Foxp3Cre) and TFR-deficient (Foxp3Cre.Bcl6fl/fl; Bcl6FC) mice with peanut or ovalbumin plus cholera toxin to induce food allergy, collected fecal samples, measured fecal …
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ROLE OF IL-10 PRODUCING EOMES+ TR1-LIKE CELLS IN MELANOMA
… that prevent the adaptive immune system’s ability to eradicate tumors are crucial for the development of effective cancer immunotherapies. In particular, the immunosuppressive functions of FOXP3+ T regulatory cells (Tregs) and EOMES+ type 1 regulatory T (Tr1) cells, which produce the …
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Sympathetic Neural Control of Inflammation by ADRB2-Mediated IL-10 Secretion
… and ADRB2 signaling enhances early induction of IL-10. In addition to its in vitro affects, I have shown that ADRB2 signaling controls inflammation in vivo. The in vivo role of this pathway was assessed by using an infection model, experimental colitis and LPS endotoxemia model. ADRB2-/- animals …
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Detection of HCMV viral IL-10 (vIL-10) in healthy blood donors
… infection, the full length transcript yields cmvIL-10, a potent immunosuppressive viral ortholog of human IL-10 (hIL-10). Alternative splicing of the UL111A transcript yields a truncated protein, LAcmvIL-10, which is expressed during both lytic and latent infection but with a limited range of …
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IL-10 Deficiency as a Factor in Airway Cellular Responses to Inhaled Sulfur Dioxide
… reactive oxygen species, and 3) deficient airway IL-10 production. This combination of factors may explain why asthmatics react with greater sensitivity to SO2 than non-asthmatics. A literature review was undertaken to evaluate the evidence in support of this postulate. While there is indirect …
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Temporal Transcriptional Regulation of IL-10-Induced Anti-Inflammatory Genes in LPS-Triggered Macrophages
<p>Interleukin-10 (IL-10) is an important anti-inflammatory cytokine acting to dampen macrophage activation during and after the immune response to microbial pathogens. During the innate immune response to gram-negative bacteria, macrophages are triggered to produce numerous pro-inflammatory …
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Regulation of Synergistic Inducible ABIN-3 Gene Expression in Response to IL-10 and LPS
… in response to the host cytokine Interleukin-10 (IL-10). The mechanisms by which IL-10 acts to restrain pro-inflammatory signaling remain incompletely defined. Previously, we identified ABIN-3 as an IL-10-inducible gene capable of inhibiting the action of the pro-inflammatory transcription …
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Gene therapy studies of Adenoviral IL-10 transduced Dendritic cells in allotransplantation / by Toby Coates.
… gene construct adenoviral interleukin-10 to inhibit alloimmune responses in both small and large animal transplantation models. There is promising in vitro evidence for gene therapy to modify dendritic cell function, which in small animal models can modify skin graft rejection. In large …
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Investigating The Role of Il-10 Producing Nkt Cells In Prevention of Graft Versus Host Disease
… studies have shown invariant natural killer T cells (iNKT) cells can prevent GVHD while preserving GVL. iNKT cells are unconventional T cells which recognize glycolipid antigens presented in the context of CD1d. Upon activation, they secrete cytokines according to the functional …
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Approaches for Enhancing Therapeutic Efficacy of a Novel IL-10 Gene Family Member: MDA-7/IL-24
… mda-7 gene is now classified as a member of the IL-10 family of cytokines and named IL-24. The mda-7/IL-24 cDNA encodes a protein of 206-amino acids with a predicted size of ~24-kDa, which contains an interleukin (IL)-10 signature motif at amino acids 101–121 (SDAESCYLVHTLLEFYLKTVF) shared by …
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Hyperinflammatory Experimental Cerebral Malaria: Coagulation and Glial Cell Activation in Plasmodium chabaudi Infection of IL-10-deficient Mice
… infection and occurs mostly in young African children. This syndrome results from a combination of high levels of parasitemia and inflammation. While mutations in inflammatory cytokine genes and the levels of cytokines found in serum and cerebrospinal fluid are correlated with the severity of …
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β-Sitosterol Isolated from Theobroma Cocoa Induces the Expression Of Mkp-1 and Il-10 In Trigeminal Neurons
… data. The anti-inflammatory mediators MKP-1 and IL-10 were up-regulated in trigeminal neurons in a concentration-dependent manner by β-sitosterol. A somewhat surprising finding from my study was that the active compound β-sitosterol functioned by a similar mechanism as that of the commonly …
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Role of PI3K and MAPK in Regulating the IL-10-Induced Temporal Transcriptional Program in LPS-Triggered Macrophages
… inflammatory state, the cytokine interleukin-10 (IL-10) induces expression of a set of anti-inflammatory genes that act to inhibit expression of TLR-induced pro-inflammatory genes. While many of the IL-10-induced genes can be induced by IL-10 stimulation alone, some others, such as TNIP3, are …
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Studies on the production of IL-1β, TNF-α, iNOS, IL-10, and ROS in the APP/PS1 mouse model of Alzheimer's disease
… demonstrated the neuroprotective effects of IL-10 in LPS-injected rat cerebral cortex, which was mediated by inhibition of NADPH oxidase activation and pro-inflammatory mediators expression. Here, we observed the expression of pro-inflammatory mediators and IL-10 in the cerebral cortex of …
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Infecção, in vitro, por Staphylococcus aureus meticilina-sensível e meticilina-resistente: produção de IL-12, IFN-γ e IL-10 por macrófagos/linfócitos de ratos submetidos à desnutrição neonatal
Staphylococcus aureus resistentes a meticilina constituem um grave problema para a saúde mundial. Alguns fatores relacionados às condições do hospedeiro predispõem às infecções por esses micro-organismos, dentre eles destaca-se a desnutrição. Assim, torna-se importante avaliar repercussões da …
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Molekulare Mechanismen der antiinflammatorischen und immunsuppressiven Effekte von Interleukin-10
Interleukin-10 (IL-10) ist ein pleiotrophes Zytokin, das von einer Vielzahl von Immunzellen gebildet wird. Im Rahmen einer Immunantwort verändert IL-10 die Expression von löslichen Mediatoren und von Zelloberflächenmolekülen in einer Weise, die zur Eindämmung einer Entzündung führt, bei …
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Charakterisierung von Monozyten anhand ihrer Interleukin-10-Produktion und Darstellund der Existenz funktionell unterschiedlicher Subpopulationen (M1/M2) analog den Th1/Th2-Schema
… aus dem Blut gesunder Spender anhand ihrer IL-10-Produktion separiert und anschließend näher charakterisiert. Fragestellung der Arbeit war, ob sich IL-10 produzierende Monozyten funktionell different von der nicht IL-10 produzierenden Subgruppe unterscheiden. Da Vorarbeiten nahe legten, dass …
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Psychoneuroimmunology of Interleukin-10
… (HPA) axis. Interleukin-10, as a prominent anti-inflammatory cytokine in the immune system, has been shown to be expressed in both the central nervous system and neuroendocrine system. Little is known, however, about IL-10's functions in the HPA axis. We hypothesize that …
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