Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"Ikaros"”.
-
IKAROS and LEUKEMIA
Acute lymphoblastic leukemia (ALL) is characterized by an accumulation of immature lymphoid cells in the bone marrow and is the most common cancer type in children. It is an immunophenotypically, morphologically, clinically, and genetically heterogeneous disorder that comprises several distinct …
-
Notch Signaling Inhibited By Ikaros1 In Human T-Cell Acute Lymphoblastic Leukemia
… of murine T-ALL models. In murine T-ALL, loss of Ikaros, a zinc finger transcriptional regulator, leads to disrupted differentiation and also cooperates with activated Notch signaling to promote T-ALL. Loss of Ikaros function most frequently results from alternative RNA splicing, which leads to …
-
Characterization of lin-42/period transcriptional regulation by the Ikaros/hunchback-family transcription factor ZTF-16 in Caenorhabditis elegans
The gene lin-42 is an ortholog of the mammalian period gene, a component of the circadian pathway that converts environmental stimuli into behavioral and physiological outputs over 24 hours. Mammalian period also regulates adult stem cell differentiation, although this function is poorly …
-
Mechanism of resistance to tyrosine kinase inhibitors in philadelphia-positive acute lymphblastic leukaemia (all): from genetic alterations to impaired RNA editing
… leukemia in mice expressing altered Ikaros (Ik) isoforms represented the background of this study. Ikaros is a zinc finger transcription factor required for normal hemopoietic differentiation and proliferation, particularly in the lymphoid lineages. By means of alternative splicing, …
-
Discovery of Dihydroartemisinin and Dasatinib Drug Combination to Cure Pooroutcome BCR-ABL+ Acute Lymphoblastic Leukemia
… (IL7), and 2) Cell-intrinsic functional-loss of IKAROS. Utilizing IL7-deficient recipient mice, we demonstrated that physiological levels of IL7 significantly attenuate the survival benefit derived from dasatinib monotherapy against Ph+ ALL. Follow-up mechanistic studies using cell signaling and …
-
Statistical methods to improve understanding of the genetic basis of complex diseases
… techniques to try and decipher the role of the Ikaros family of transcription factors in T1D pathogenesis. I find that T1D-associated variants are enriched in Ikaros binding sites in immune-relevant cell types, but that there is no evidence of epistatic effects between causal variants residing …
-
Charakterisierung von HSS-2, einer B-zellspezifischen, regulatorischen DNA-Sequenz im Bereich des Ig(lambda)-Enhancers des Menschen
… an die Sequenz des HSS-2-Bereichs ist von E47, Ikaros und NFkB anzunehmen. Alle drei stellen Transkriptionsfaktoren dar, die die B-Zellentwicklung und -differenzierung in verschiedenen Stadien steuern. Als Masterfaktor für die Chromatinöffnung im Igl-Locus kommt vermutlich E47 in Frage, die …
-
The Role of IkZF Factors in Mediating TH1/TFH Development and Flexibility
… such, we see that in the presence of IL-2, the Ikaros Zinc Finger (IkZF) transcription factor Eos is upregulated in TH1 cells, with this factor playing a significant role in promoting regulatory and effector functions of TH1 cells. Moreover, we show that Eos forms a novel protein complex with …
-
Insights Into the Regulatory Requirements for T Follicular Helper Cell Development
… novel regulatory mechanism wherein STAT3 and the Ikaros zinc finger transcription factors Ikaros and Aiolos cooperate to regulate Bcl-6 expression in these TFH-like cells. Collectively, the work in this dissertation significantly advances our understanding of the regulatory mechanisms that govern …
-
Pax5 Haploinsufficiency Cooperates with BCR-ABL1 to Induce Acute Lymphoblastic Leukemia
… <em>EBF1</em>, <em>LEF1</em>, <em>IKZF1</em> (IKAROS), and <em>IKZF3</em>(AIOLOS). These findings suggest that direct disruption of pathways controlling B-cell development and differentiation contributes to B-progenitor ALL pathogenesis. Moreover, these data demonstrate the power of …
-
Novel markers for human T regulatory cells in healthy donors and cancer patients
… FoxP3+ Tregs express Helios, a member of the Ikaros transcription factor family. The purpose of this study is to identify which of FoxP3+/-Helios+/- Tregs express GARP and LAP and to investigate if these receptors are vital markers for activated conventional Tregs, and also to examine the …
-
Characterization of Transcriptional and Post-transcriptional Regulation of lin-42/Period During Post-embryonic Development of C. elegans
… We identified ZTF-16, a member of the Hunchback/Ikaros zinc-finger transcription factor family, as a potential lin-42 activator and, using quantitative real-time PCR, confirmed that ztf-16 mutation results in down-regulation and loss of cycling expression of lin-42. We further determined that …
-
Contribution à la compréhension de l'immunopathogénie de l'aspergillose nasosinusale chez le chien
… branch of the immune response (IL-16 and Ikaros). The sequencing analysis of the promotor region of the gene encoding IL-10 revealed the presence of polymorphisms. Three polymorphisms were observed more frequently in clones belonging to the three studied cohorts, excepted for the clones …
-
Investigation of the anticancer activity and mechanisms of zinc diethyldithiocarbamate in multiple myeloma
… on the mRNA expression of cereblon (CRBN), Ikaros (IKZF1), aiolos (IKZF3) and Interferon regulatory factor-4 (IRF4), a significant downregulation of protein levels was observed after treating the MM cell lines with sub-cytotoxic concentrations of ZnDDC (2-5 μM). After exposure to low …
-
SoMa (Sound Masses): A modular system for data-driven algorithmic composition with large sample libraries, focusing on the dynamic formation and control of spatialised sound groups
Η έρευνα αυτή αφορά την ανάπτυξη ενός συστήματος στο Max/MSP, βασισμένου στην Ανάκτηση Μουσικής Πληροφορίας (Music Information Retrieval) και σε διάφορους μηχανισμούς αναζήτησης για την πλοήγηση σε μεγάλες βιβλιοθήκες από samples. Διερευνά τον δυναμικό σχηματισμό και έλεγχο υποομάδων της μεγάλης …
-
The role of GATA-1 isoforms in haematopoiesis
… of alternative lineage genes (PU.1 and Ikaros) and genes associated with progenitor proliferation (cyclin D2 and c-myb). GATA-1s, in contrast, produced less evidence of differentiation with lower DNA ploidy, less up-regulation of erythroid genes and failure to repress other lineage and …