Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 2 of 2 for “"Ii-hmgr"”.
-
Design, Synthesis, And Evaluation Of Molecular Inhibitors For Biologically Relevant Enzymes
… of molecules for the inhibition of the Class II HMGR enzyme. The work on this subject involved the de novo design and in silico screening of a set of phenothiazine molecules for the inhibition of II-HMGR. These molecules were synthesized and assayed against II-HMGR, resulting in the …
-
Understanding and Harnessing the Structural Features that Govern HMG-CoA Reductase Activity
… 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR), which catalyzes the reduction of HMG-CoA to mevalonate using two equivalents of the cofactor NAD(P)H, is part of the mevalonate pathway, found in all kingdoms of life. This pathway is at the heart of natural product biosynthesis constituting …