Global ETD Search
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Showing 1 to 5 of 5 for “"Igh locus"”.
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Characterization of Loop Extrusion and Regulatory Elements in IgH Locus Structure and Function
V(D)J recombination is a highly ordered and stepwise process that enables antigen receptors to detect a wide variety of antigens. The Igh locus undergoes large-scale locus contraction prior rearranging in pro B cells. A series of nested chromatin loops anchored by a series of distal VH enhancers, …
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Investigation of the three dimensional organisation of the genome in B cell development
… multimegabase murine immunoglobulin heavy chain (Igh) and immunoglobulin kappa chain (Igκ) loci must not only facilitate recombination between gene segments separated by up to 3Mb, but diverse recombination events. To understand how this is achieved a capture Hi-C (CHi-C) approach was developed to …
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Spatial organisation of the immunoglobulin heavy chain locus and inter-chromosomal gene networks driving B cell development
… recognize a countless number of antigens. This highly diverse repertoire is produced during B cell development in the bone marrow from the immunoglobulin heavy chain (Igh) and light chain (Igk and Igl) loci. The mouse Igh is a large (~3Mb) multigene locus that contains 195 variable (V), 10 …
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The Role of ZMYND8 in Immunoglobulin Class Switch Recombination
… actively transcribed immunoglobulin heavy chain (Igh) switch donor and acceptor DNA. The 3' Regulatory Region (3'RR), a prototypical super-enhancer located at the 3' of the Igh locus, is essential for acceptor switch region transcription, but the mechanism by which it regulates this process is not …
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STUDIES OF B CELL DEVELOPMENT AND V(D)J RECOMBINATION
… (VH) genes in the immunoglobulin heavy chain locus. The ability to produce antibodies is restricted to the B cell lineage and is tightly regulated, starting with the temporal separation of the recombination process, in which DH-JH precedes VH-DHJH recombination. Successful recombination of …