Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"IgE antibodies"”.
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Clinical Significance of Specific IgE Antibody Levels to Egg White, Ovalbumin and Ovomucoid in Egg Allergic Children Under 24 Months
… most common food allergies in children. Specific IgE antibodies to egg white is associated with the outcome of oral challenge tests, and specific IgE antibodies to ovomucoid have been suggested as prognostic factors of clinical tolerance to heated egg in children with egg allergy. The aim of this …
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Engineering protein-based modulators of allergic, temporal, and checkpoint blockade anti-cancer immunity
… allergic reactions against cancer by designing IgE class antibodies against two mouse tumor antigens and comparing them with traditional IgG antibodies. These IgE antibodies elicited modest or no tumor control, and limited efficacy could be due to fast pharmacokinetic clearance, absence of …
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Regulation of Arachidonic Acid Pathway and Eosinophilic Inflammation in Chronic Rhinosinusitis/ Nasal Polyposis. Potential Role of Staphylococcus aureus Enterotoxins
… of eosinophil-related mediators, as well as of IgE antibodies to S. aureus enterotoxins. Furthermore, eicosanoid release evaluated in nasal polyp patients showed an increase of leukotrienes and lipoxin A4 in patients with immune response - 18 - against S. aureus enterotoxins, which seem to be …
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Allergen Sensitization and Immunomodulation By Synthetic Ligands, Pul-042, In An Allergen-Induced Asthma Murine Model
… cells, which triggers production of IgE antibodies, the up-regulation of T<sub>H</sub>2-specific cytokines (<em>i.e. </em>IL-4, IL-5, IL-9 and IL-13), increased airway eosinophilia, and mucin hypersecretion. Although there are several therapeutics currently treating asthmatic …
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The Prevalence and Clinical Significance of Newly Sensitization to Inhalant Allergens in Toluene Diisocyanate-induced Asthmatic Patients
… the result of skin-prick test and serum specific IgE antibodies to common inhalant allergens monitored every year. The clinical features, drug requirements for systemic steroids, frequency of admission and degree of airway hyper-responsiveness were compared between the two groups. RESULTS: …
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Characterization of Allergen-Specific Immunoglubulin E Development in a Food Allergy Model and Its Regulation by T Follicular Helper and T Follicular Regulatory Cells
… and serious disease regulated by immunoglobin E (IgE) antibodies specific for food allergens.The development of IgE is regulated by T follicular helper cells (TFH) and T follicular regulatorycells (TFR) in the germinal center (GC). We aimed to understandthe regulation of IgEin the GC by TFH and …
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Identification and Analysis of Peanut and Soybean Cross Reacting Allergens in Korean Children Sensitive to Peanut
… of allergic patients with high level of soybean-IgE without clinical soybean allergy, especially in patients with high level of peanut-IgE. OBJECTIVE: The aim of this study was to evaluate the IgE binding proteins in both species, with a goal of identifying homologous epitopes of peanut and …
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The Role of ASK1 in Allergen-mediated Mast Cell Signaling and Activation-dependent Inflammatory Responses
… and dendritic cells. However, its role in IgE-FcERI-activated mast cells remains elusive. The purpose of this project is to expand on current knowledge of MAPK signaling and the role of ASK1 in mast cell-mediated allergic inflammation. Bone marrow-derived mast cell and fetal liver-derived …
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Investigating role of IL-4 receptor alpha (IL-4Ra) in murine models of atopic dermatitis
… common allergens, together with increased serum IgE antibodies, characterise the disease. B and T cells are essential in the disease manifestation, however, the exact mechanism of how these cells are involved in skin sensitization to allergens is unclear. Clinical studies investigating the …
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Characterizing the Innate Immune Response of Human Airway Cells to the Unique Fungal Allergen Alt a 1
… sensitized to Alternaria, have Alt a 1 specific IgE antibodies indicating that it is a major and clinically relevant allergen. Although progress has been made over the past few decades regarding elucidating the mechanistic underpinnings of allergic inflammation, more research needs to be done, …
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EOSINOPHILIC INFLAMMATION IN NASAL POLYPOSIS: REGULATION OF INTERLEUKIN 5 AND INTERLEUKIN 5 RECEPTOR α ISOFORMS
… IL-5 and eotaxin in NP tissue. Although elevated IgE levels are found in NP, total IgE and IgE antibodies in NP tissue was unrelated to skin prick tests, but correlated with the degree of eosinophilia. In addition, we demonstrated the organisation of secondary lymphoid tissue in NP tissue and a …
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Modeling steric effects in antibody aggregation using rule-based methods
… in turn, is initiated by the aggregation of antigens and IgE-FcεRI antibody-receptor complexes. Computational modeling of antibody- antigen aggregate formation as well as the size and structure of these aggregates is an important tool for greater understanding of the allergic response. In …
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Role of Toll-like receptors in airway inflammation
… Of these, a reduction in serum allergen-specific IgE antibodies, correlating with cell-bound IgE and IgG expression, along with a general activation of T cells were most prominent. The novel findings in this report included a shift in monocyte populations and decrease in levels of TLR2 and TLR4. …
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Effects of IL-33 on the interaction between HMC-1 cells and human airway smooth muscle cells
… most common form. Most cases are initiated by IgE antibodies, generally referred to as IgE-mediated allergic asthma. Treatments include β2-agonists and inhaled corticosteroids, although there is no definitive cure for the disease. Asthma results in a plethora of pathological processes, present …
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메밀알레르기의 생쥐모델 개발과 비강내 면역요법 후 특이 IgE 생성의 변화
… study is designed to develop a murine model of IgE-mediated buckwheat hypersensitivity induced by intragastric sensitization with native buckwheat flour. During the procedure it was intended to determine not only the qualitative and quantitative differences of IgE production dependent upon …
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Structural and ligand binding studies of toll-like receptor 4 (TLR4) associated proteins
… receptor 4 (TLR4) and myeloid differentiation antigen (MD-2). As described in Chapter 1, LPS-dependent complex formation of TLR4/MD-2 heterodimers results in the activation of pro-inflammatory signaling cascades. Although inflammation is usually host protective, when uncontrolled it can cause host …
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Untersuchung zum Risikoprofil hinsichtlich einer Sensibilisierung mit Rinderallergen unter besonderer Berücksichtigung der verschiedenen Rinderrassen
… klinischer und Labordiagnostik, d.h. eindeutige klinische Reaktionen finden keine Bestätigung durch Allergietestung mit kommerziellen Extrakten. Patienten berichten auch, unterschiedliche Reaktionen auf unterschiedliche Rassen zu zeigen. Noch gibt es aber keine Studien zu rassespezifischen …