Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 224 for “"IgE"”.
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Post-transcriptional regulation of IgE
… als sekretorische Form oder als membranständige Form. Die sekretorische Form der Immunglobuline bildet den Effektorarm des humoralen Immunsystems. Als integrale Membranproteine auf B Lymphozyten sind sie verbunden mit diversen Signaltransduktionskaskaden. Die Signale, die durch die …
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Molecular basis of Fce receptor: IgE interactions
… allergen crosslinking at least two molecules of IgE bound to their high-affinity cell surface receptor FceRI. This interaction initiates intracellular signalling starting a cascade of events resulting in cellular degranulation and the release of inflammatory mediators. Many present treatments for …
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IgE and IgG Binding Patterns to Dermatophoides Pteronyssinus and Dermatophagoides Farinae in Children with Atopic Dermatitis : An IgE Immunoblot Analysis
… 이용한 D. pteronyssinus와 D. farinae 조항원에 대한 IgE 및 IgG 항체 결합 양상 비교 목적: 집먼지진드기 항원에의 감작은 주로 4-5세 이상의 소아나 성인에서 의미 있게 관찰되나 3세 미만의 영 유아에서도 중요한 원인이 될 수 있다. 성인 환자들을 대상으로 시행한 외국의 연구에 의하면 140 kD-6 kD 사이의, 최소 32개의 IgE 결합 단백이 존재하며, 이 중 Group I(약 25 kD), Group II(약 15 kD), 및 Group III(약 30 kD) 항원이 주요 …
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Gene-Targeting zur Herstellung einer IgE überexprimierenden Maus
… neues Mausmodell vor, mit dem der Einfluß von IgE in der Entstehung einer Allergie und die Folgen vermehrter IgE-Produktion in-vivo untersucht werden können. Erreicht wurde dies durch eine definierte Mutation im Erbgut von Mäusen. Mittels homologer Rekombination wurde durch ein …
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Klinisch-genetische Definition des Hyper-IgE-Syndroms (HIES)
Das Hyper-IgE-Syndrom (HIES) ist ein seltener primärer Immundefekt, charakterisiert durch die klinische Trias: chronisches Ekzem mit einem Gesamt-IgE über 2000 IU/ml im Serum, rezidivierende Infektionen (insbesondere Abszesse, Infektionen des Respirationstraktes wie Pneumonien mit …
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B cell memory in STAT3 Hyper-IgE Syndrome: Cytokine integration, IgE regulation, and the architecture of human memory B cell subsets
Deleterious allergen-specific IgE responses cause lifelong and life-threatening allergic disease. However, the cellular reservoir of IgE memory in humans is incompletely characterised and prior studies have been unable to reproducibly detect human IgE+ memory B cells (MBCs). Individuals with Inborn …
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메밀알레르기의 생쥐모델 개발과 비강내 면역요법 후 특이 IgE 생성의 변화
… study is designed to develop a murine model of IgE-mediated buckwheat hypersensitivity induced by intragastric sensitization with native buckwheat flour. During the procedure it was intended to determine not only the qualitative and quantitative differences of IgE production dependent upon …
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IGE PRODUCTION REGULATION VIA CD23 STALK ENGAGEMENT AND CELL CYCLE STIMULATION
CD23, the low affinity receptor for IgE, is expressed mainly on B cells and has been shown to regulate IgE production. Previously, recombinant mouse and human CD23 were constructed with a trimerizing isoleucine zipper motif attached in frame to the N-terminus of the entire extracellular CD23 …
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Identifizierung und Charakterisierung IgE- reaktiver Proteine in der Tomate (Lycopersicon esculentum)
Zur Detektion neuer IgE- reaktiver Proteine wurde in dieser Arbeit ein zweidimensionales Proteintrennverfahren verwendet. Resultierende Proteinfraktionen wurden mithilfe von 18 tomatensensibiliesierten Patientenseren im Immunoblot getestet. Detektierte Proteine in der SDS-PAGE wurden mittels …
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Investigating the negative regulatory role of neurogranin in IgE-mediated mast cell activation
… plethora of pro-inflammatory mediators following IgE-mediated activation. Calcium mobilization following mast cell activation is essential for degranulation and pro-inflammatory cytokine/chemokine production, processes that require the Ca2+/calmodulin (CaM)-dependent phosphatase, calcineurin. …
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Μελέτη μιας νέας μετάλλαξης στο γονίδιο STAT3 που ενέχεται στο σύνδρομο ανοσοανεπάρκειας Hyper-IgE
Το σύνδρομο Hyper-IgE (HIES) είναι μια σπάνια πρωτοπαθής ανοσοανεπάρκεια η οποία χαρακτηρίζεται από υψηλά επίπεδα IgE στον ορό, υποτροπιάζουσες σταφυλοκοκκικές λοιμώξεις του δέρματος και επεισόδια πνευμονίας με σχηματισμό κύστεων. Επιπλέον, στο φαινότυπο του συνδρόμου περιλαμβάνονται και …
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Polymorphisms of High-affinity IgE Receptor Genes in Patients with Aspirin-Intolerant Chronic Urticaria
… is not completely understood, an IgE-mediated response was reported for a patient with aspirin-intolerant chronic urticaria (AICU). Atopy was reported a risk factor for a patient with AICU and approximately 40% of patients with chronic urticaria have autoimmune urticaria. The …
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