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Showing 1 to 13 of 13 for “"IgA nephropathy"”.
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Biomarkers in IgA nephropathy
Contains fulltext : 140179.pdf (Publisher’s version ) (Open Access)
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IgA Nephropathy study according to the Oxford Classification: IgA Nephropathy clinical-morphological correlations, disease progression and the effect of renoprotective therapy
Immuunoglobuliin A nefropaatia (IgAN) on kõige sagedasem glomerulonefriit maailmas. Diabeetilise nefropaatia kõrval on IgAN järgmine oluline nefroloogiavaldkonna probleem, kuna haigestuvad peamiselt noored inimesed ja aeglaselt progresseerudes tekib lõpp-staadiumi neerupuudulikkus ligikaudu pooltel …
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Studies of the pathogenesis of IgA nephropathy and Henoch-Schönlein purpura, with special reference to Streptococcus pyogenes infections and complement
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis and Henoch-Schönlein purpura (HSP) the most common form of vasculitis in childhood. HSP may affect kidneys, a complication termed Henoch-Schönlein nephropathy (HSN). Renal pathology in HSN resembles that seen in IgAN. The …
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Untersuchung von cosmc-Mutationen bei Patienten mit IgA-Nephropathie
Altered IgA1 galactosylation is involved in the pathogenesis of IgA nephropathy (IgAN), the most common glomerulonephritis in the world. The galactosyltransferase core-1 beta3-galactosyltransferase-1 (C1GALT1) and its chaperone cosmc are specifically required for O-galactosylation of the IgA1 hinge …
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Clinico-pathological correlation and outcome in patients with mesangioproliferative glomerulonephritis in Cape Town: A single centre study
… glomerulonephritides in Africa, despite the non-IgA subtype being reported as a common cause of nephrotic syndrome. This study will assess the outcome of patients with biopsy proven mesangioproliferative glomerulonephritis (MesPGN) from a single centre in Cape Town, South Africa. Methods The …
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Vitamin D and cardiac autonomic tone: Cardiovascular implications in humans with and without chronic kidney disease
… The same study with vitamin D deficient IgA nephropathy (IgAN) subjects yielded similar results. The VITAH Trial then aimed to assess whether a causal relationship existed between activated vitamin D supplementation and CAT in end-stage kidney disease (ESKD) patients requiring …
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The role of glycoproteins in glomerular pathophysiology
… and progression of CKD are still not fully investigated. Two of the most common examples of CKD are diabetic kidney disease (DKD) and IgA nephropathy (IgAN). This thesis is focusing on the role of specific glycoproteins in these diseases and possible biomarkers for diagnostic purposes. The first …
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Untersuchungen zur Analyse der O-Glykosylierung des IgA1-Moleküls im Krankheitsbild der IgA-Nephropathie
… HAA from Helix aspersa and Jacalin towards IgA1 O-glycans were characterized in detail. The aim was to evaluate existing techniques for the detection of undergalactosylated IgA O-glycans in IgA nephropathy and to develop and analyse new detection methods. A set of serum samples from IgAN …
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Energetic and dynamic characterization of the IgA1:FcαRI interaction reveals long-range conformational changes in IgA1 upon receptor binding
The interaction between immunoglobulin A (IgA) and the IgA-specific receptor, FcαRI, initiates a pro-inflammatory immune response in the presence of a multivalent antigen, and has recently been shown to possess an anti-inflammatory role in the absence of antigen. Additionally, soluble FcαRI has …
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A ten year retrospective study of the aetiology and outcome of crescentic glomerulonephritis in children presenting to the Red Cross Children's Hospital, Cape Town, South Africa
… in 11(57.9%), idiopathic in 4(21%), HSP/IgA nephropathy in 2 (10.5%), SLE in 1 (5.3%) and mesangiocapillary glomerulonephritis in 1(5.3%). Fourteen of the subjects were male thus giving a male to female ratio of 1.4 while the mean age of the children was 8.3 [range- 1 to 14 years]. The …
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Studies of immunoglobulin receptors and human proximal tubular cells
… There are many forms of GN, of which IgA nephropathy (IgAN) is the most common, affecting up to 2% of the adult population. GN is characterised by irreversible and progressive glomerular and tubulointerstitial fibrosis, reduction in glomerular filtration rate (GFR), and retention of …