Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Ig-Gene"”.
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The VH repertoire and clonal diversification of B cells in myositis and vasculitis
… in a number of disorders to a variety of self antigens but the precise cellular and molecular mechanisms resulting in pathology are largely unresolved. In some instances T cell mediated reactions are thought to be the main contributors to disease mechanisms but it is becoming increasingly evident …
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The Role of Activation-Induced Cytidine Deaminase in Antibody Diversification and B Cell Malignancies
… affinity of an antibody for its corresponding antigen by introducing point mutations within the variable region of the immunoglobulin (Ig) gene heavy chain locus. CSR replaces the Ig μ constant region with one of the downstream constant region, thereby changing the physical properties of the …
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MODULATION OF THE B-CELL REPERTOIRE IN RHEUMATOID ARTHRITIS BY TRANSIENT B-CELL DEPLETION
… understood, their importance in the pathogenesis of autoimmune diseases has been more appreciated in the past few years. It is now well known that they have roles in addition to (auto) antibody production and are involved by different mechanisms in the regulation of T-cell mediated …