Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Ig genes"”.
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The evolution of the autoantibody response in Graves’ disease
… and environmental factors contribute to pathogenesis and one such factor is the infectious agent, Yersinia enterocolitica. Two high affinity TSAbs, (KSAbl, lgG2t>/K; KSAb2, IgGaa/K), developed from an experimental murine model of GD, share common germline Ig genes and thus are derived from the …
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Genome-Wide Characterization of the Effects of Nucleic Acid Modifying Enzymes: Cytidine Deaminases and DNA Methylation
… mutations are introduced into immunoglobulin (Ig) genes, and class-switch recombination (CSR), in which genomic constant regions are recombined to encode antibodies of different isotypes. Both of these processes require AID-catalyzed C-to-U lesions at the Ig loci, which are resolved to generate …
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The role of DEAD-box helicase 1 in humoral immune responses
… of B-cells to recognise an endless array of antigens through their immunoglobulin (Ig) genes and secret these as soluble antibodies to help combat invading pathogens. Primary diversification occurs through VDJ recombination during B-cell development, whereas secondary diversification occurs …
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The VH repertoire and clonal diversification of B cells in myositis and vasculitis
… in a number of disorders to a variety of self antigens but the precise cellular and molecular mechanisms resulting in pathology are largely unresolved. In some instances T cell mediated reactions are thought to be the main contributors to disease mechanisms but it is becoming increasingly evident …
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MODULATION OF THE B-CELL REPERTOIRE IN RHEUMATOID ARTHRITIS BY TRANSIENT B-CELL DEPLETION
… understood, their importance in the pathogenesis of autoimmune diseases has been more appreciated in the past few years. It is now well known that they have roles in addition to (auto) antibody production and are involved by different mechanisms in the regulation of T-cell mediated …
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Molecular Insights of Primary Thyroid B-cell Lymphomas by Somatic Genetic and Immunogenetic Profiling
… of genetic changes that cooperate with antigenic stimulations during lymphomagenesis. The present thesis aimed to further elucidate the somatic genetic and immunogenetic profiles of primary thyroid lymphomas including EMZL, FL and DLBCL. In particular, the findings presented in this thesis …