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Showing 1 to 2 of 2 for “"Igκ locus"”.
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Investigation of the three dimensional organisation of the genome in B cell development
… chain (Igh) and immunoglobulin kappa chain (Igκ) loci must not only facilitate recombination between gene segments separated by up to 3Mb, but diverse recombination events. To understand how this is achieved a capture Hi-C (CHi-C) approach was developed to investigate interactions within the …
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Regulation of Accessibility of the Variable Gene Segments of the Mouse Immunoglobulin Kappa Light Chain Gene Locus
… nucleotide sequence of the 3.2 Mb Mus musculus Igκ gene locus and mapped all of the functional and pseudo-Vκ genes onto the sequence. I have also determined the patterns of potential transcription factor binding sites surrounding these Vκ genes. These analyses revealed statistically significant …