Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Ifenprodil"”.
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Effects of Ifenprodil on the Gating or NR1/2B NMDA Receptors
… differentially controls NMDA receptor activity. Ifenprodil binds to the ATD of NR1/NR2B receptors inhibiting the receptors. To delineate the effects of ifenprodil on NR1/NR2B receptor gating, we recorded steady state currents from cell attached and excised outside out patches at pH7.9. NR1/NR2B …
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The Structural Mechanism of Allosteric Modulation of The Nmda Receptor: A Balance of Tensions
… receptor, respectively. The synthetic compound ifenprodil also binds the ATDs and inhibits the receptor. We used luminescence resonance energy transfer to study the structural changes accompanying modulator binding and then linked those conformational changes to the function of the receptor …
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Propriedades eletrônicas, estruturais e espectroscópicas de diazocetonas através de cálculos quânticos e estudos in silico das ligações realizadas pela molécula de amurensinina no sítio de ligação do receptor específico de N-metil-D-Aspartato (NMDA)
… com aquelas existentes entre o antagonista ifenprodil e os sítios de ligação do mesmo receptor. Os resíduos de aminoácidos do receptor envolvidos nas interações com a amurensinina não protonada e protonada estão localizados na região do domínio ATD e os dados e informações obtidos acerca …
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The role of auditory sensory input during functional pre- and postsynaptic maturation of the calyx of Held synapse
… to the NR2B subunit-specific antagonist ifenprodil in P14-17 synapses of CaV1.3-/- deaf compared to wt mice. These results suggest that auditory activity is required for the adjustment of synaptic strength as well as for the down regulation of synaptic NMDARs during postnatal development …
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Exzitotoxizität im ZNS bei Mausmutanten mit veränderten Glutamatrezeptoren
… suppressed by the NR2B subunit-specific blocker ifenprodil, indicating that Ca2+-influx occurred only through NR2B channels. Thus, in the absence of fully functional NR2A channels, excitotoxicity can be triggered only by the NR2B subtype. In cultured neurons expressing NR2B only in its …
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Functions of GluN2D-containing NMDA receptors in dopamine neurons of the substantia nigra pars compacta
… intervention using subunit-specific inhibitors ifenprodil and DQP-1105 on elicited NMDAR-EPSCs suggested a developmental shift from primarily GluN2B to GluN2B/D. Activity dependent regulation was assessed by high frequency burst stimulation of glutamatergic afferents: in comparison to controls, …