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Showing 1 to 20 of 36 for “"Idiopathic Pulmonary Fibrosis"”.
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The pathogenesis of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a restrictive pulmonary disorder of unknown aetiology with a relentless disease course and a median survival of 3 years after the diagnosis. It is the most common idiopathic interstitial lung disease (ILD) with a basal and peripheral predominance associated …
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Approaches to lead generation for idiopathic pulmonary fibrosis targets
Idiopathic pulmonary fibrosis (IPF) is a common and devastating lung disease. There is currently no cure for IPF, and the limited pharmaceutical agents available to patients do not improve lung function, and only give moderate improvements in quality of life. Consequently, IPF is a major cause of …
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A study of platelets and the endothelium in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease associated with significant morbidity and early mortality. Despite this, the pathogenesis remains poorly understood and there is no effective disease modifying treatment. Epidemiological studies demonstrate an association between IPF …
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CHARACTERIZATION AND EVALUATION OF CLINICALLY RELEVANT READOUTS IN A PRE-CLINICAL MODEL OF IDIOPATHIC PULMONARY FIBROSIS (IPF)
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive age-related interstitial lung disease (ILD) with a poor prognosis and very limited therapeutic options (Raghu et al. 2015; Spagnolo et al. 2018). To date, Pirfenidone and Nintedanib are the only two therapies approved for IPF worldwide. …
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The Association of demographic and physiological variables and risk of subsequent disease progression in idiopathic pulmonary fibrosis
Background. Efficient clinical trial design in idiopathic pulmonary fibrosis (IPF) is hindered by incomplete understanding of the natural history of IPF and absence of robust predictive models. A retrospective analysis of the RAINIER clinical trial for simtuzumab, an inhibitor of …
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Tissue repair in lung disorders
… phase of tissue repair in lung disorders such as idiopathic pulmonary disease, asthma, obliterative bronchiolitis, and after lung transplantation is not well understood. One of the key players in fibrosis is the fibroblast and its progenitor, the fibrocyte. The fibroblast is the main producer of …
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Sine Oculis Homeobox Homolog 1 (Six1) Plays A Critical Role In The Progression of Pulmonary Fibrosis.
<p>Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia with a median survival time of 2-4 years after diagnosis. The alarming mortality rate is due to the lack of effective treatments. IPF is a chronic disease that is characterized by alveolar destruction due to …
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Role of Nudt21 Mediated Alternative Polyadenylation and Hyaluronan In The Development of Pulmonary Hypertension
<p>Pulmonary hypertension (PH) is a progressive disease with serious effects on quality of life and life expectancy of patients. PH is a complex disease that likely develops due to multiple influences, and no curative treatments exist for this disease. It has been shown that alternative …
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Contribution of Interleukin 6 Trans Signaling In Pulmonary Fibrosis
<p>Idiopathic Pulmonary Fibrosis (IPF) is a lethal lung disease with progressive fibrosis and death within 2-3 years of diagnosis. IPF incidence and prevalence rates are increasing annually, and because the pathogenesis is unknown, there are no effective treatments available. Inhibition of …
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The expression profile of cytoglobin in human fibrotic lung, and the protective role of cytoglobin in hypoxia and oxidative stress in vitro
… of fibrotic lesions taken from patients with Idiopathic Pulmonary Fibrosis (IPF) and Chronic Obstructive Pulmonary Disease (COPD). CYGB staining was observed in fibroblasts, endothelial cells, type II pneumocytes, type I pneumocytes, haematopoietic stem cells and inflammatory cells, which were …
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Understanding the Effect Of 1,3-Butadiene on Human Lung Fibroblasts: Does Exposure to 1,3-Butadiene Induce Senescence?
… of lung diseases, such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and cancer, by inhibiting normal lung fibroblast function and repair.
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The Hypoxic Adenosine Response Modulates Macrophage Differentiation and Contributes to Lung Disease
<p>Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease which affects 5 - 8 million individuals worldwide and 200,000 individuals in the United States alone. Although prevalent, we do not know what causes IPF and no effective curative treatment exists for this disease. Our laboratory has …
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Investigation of efficacy and mechanisms of action in mesenchymal stromal cell therapy for chronic lung diseases
… lung diseases, specifically Chronic Obstructive Pulmonary Disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF). In vitro characterisation of MSC demonstrated significant cytoprotective and reparative effects, through inhibition of epithelial apoptosis, suppression of neutrophil functions and …
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Alternative Polyadenylation Modulates Expression of Pro-Fibrotic Proteins and Contributes to Lung Fibrosis
<p>Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease which affects about 5 to 8 million individuals in the world. Despite the high prevalence, there is currently no cure for IPF, and the cause of this disease is still unclear. Our laboratory and collaborators have shown that nudix …
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The Role of A2B Adenosine Receptor Signaling In Adenosine Dependent Lung Disease
… and acute lung injuries are two distinctive pulmonary disorders that result in significant morbidity and mortality. Adenosine is a signaling nucleoside generated in response to injury and can serve both protective and destructive functions in tissues and cells through interaction with four …
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Algorithms And Tools For Computational Analysis Of Human Transcriptome Using Rna-Seq
… from non-differentially expressed genes of human idiopathic pulmonary fibrosis (IPF) lung disease.</p>
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INTERROGATING THE ROLE OF N6-METHYLADENOSINE RNA MODIFICATION ON TELOMERASE BIOLOGY
… of hTR leads to degenerative diseases such as idiopathic pulmonary fibrosis and aplastic anemia. Due to the severe nature of these diseases and absence of pharmaceutical interventions, it is important to understand the regulation of hTR in hopes that drug targets can be identified. The 3’ …
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Clinical evaluation of fibrotic idiopathic interstitial pneumonia
Idiopathic pulmonary fibrosis (IPF) is a fatal condition with limited treatment options. The diagnosis is usually made radiologically but a careful history to exclude identifiable causes of interstitial lung disease is required. Although the median survival is poor, there is considerable …
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