Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Id2"”.
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The Role and Regulation of Id2 In Dendritic Cells
… regulators inhibitor of DNA binding 2 (Id2) and the E protein E2-2 direct type 1 conventional DC (cDC1) and plasmacytoid DC (pDC) development, respectively. Though the requirement of Id2 in cDC1 lineage development during the steady state is well established, roles for Id2 in DC subset …
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Structural characterization and biochemical analysis of ID2, an inhibitor of DNA binding
… to inactivate their DNA-binding abilities. ID2, a member of the ID family was cloned, expressed and purified using strategies to overcome the known instability of this protein both in vitro and in vivo. The crystal structure of ID2 was solved to 2.1 ? and showed for the first time, a loop …
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Regulation of RNA polymerase III transcription by the ID1, ID2, ID3 and E47 proteins
RNA polymerase III (pol III) is responsible for transcribing a set of genes that are involved in protein synthesis, including transfer (tRNA) and 5S ribosomal RNA (5S rRNA). Pol III transcription levels are increased in many cancers, as increased protein synthesis is required for tumour growth. …
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Targeting Transcription Factors in Neuroblastoma: Development of Aurora Kinase A/N-Myc Degraders and ID2 Chemical Probes
… properties of 2.3. Inhibitor of DNA-binding 2 (ID2) has been found to be critical for tumorigenesis and its expression is strongly predictive of poor prognosis for neuroblastoma patients. However, validation of ID2 as a viable protein target for neuroblastoma remains an understudied area in drug …
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The Role of Id Proteins in the Development and Function of T and B Lymphocytes
… this thesis, I focused my study on the role of Id2 in gamma delta T cells and CD4<super>+</super> alpha beta T cells, as well as the role of Id3 in B cells.</p><p> Id proteins have been shown to control gamma delta T cell development. Id3 knockout mice demonstrate a dramatic expansion of …
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BREAST CANCER PROGRESSION AND METASTASIS: DISCOVERY OF NOVEL GENES AND THEIR FUNCTIONAL STUDY
… MCF10A and DCIS.com cell line, we identified ID2 as a regulator of DCIS initiation. ID2 promoted DCIS formation by enhancing cancer stemness of premalignant cells. On the other hand, we compared the DCIS.com and invasive breast cancer cell line, MCF10CA, and identified INHBA and GJB2 as novel …
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Untersuchungen zur Identifikation von Interaktionspartnern der Nemo-like-Kinase, Nlk
… (Cdks), die die inhibitorischen HLH Proteine Id2 und Id3 phosphorylieren, und die Beteiligung von HLH Transkriptionsfaktoren an der Entwicklung des Knochenmarks und des Zerebellums legten den Gedanken nahe, dass Id2 bzw. Id3 Interaktionspartner der Nlk sein könnten. Für das …
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Identification of Anti-Beta2 Glycoprotein I Auto-antibody Regulated Gene Targets in the Primary Antiphospholipid Syndrome Using Gene Microarray Analysis
… factors/signaling molecules including ID2. Microarray results were confirmed for selected genes (CSF3, CX3CL1, FGF18, ID2, SOD2, Tenascin C) using quantitative real-time RT-PCR analysis. This study revealed a complex anti-2GPI-regulated gene expression profile in HUVEC in vitro. The …
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Genetic Networks Modulating Retinal Injury
… and proliferation). Third, candidate genes Id2 and Lpin1 are current modulators for the network controlled by the chromosome 12 locus. Higher levels of Id2 and Lpin1 correlated with higher levels of the survival gene Crygd, and with lower levels of acute phase genes Fos and Stat3, reactive …
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Transcriptional Regulation by Hypoxia-Inducible Factors in Tumor Cells
… expression of the negative transcription factor ID2 (Paper I), involved in blocking the function of tissue-specific basic helix-loop-helix (bHLH) proteins, such as the SNS-specifying transcription factors HASH-1 and dHAND. Hypoxic up-regulation of ID2 was dependent on direct in vivo DNA-binding …
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Investigating the impact of endothelial BMPR2 loss on the proliferative response to bone morphogenetic protein 9 in pulmonary arterial hypertension
… of DNA-binding/differentiation genes, ID1 and ID2. In vivo, BMP9 administration reduced neonatal retinal and pulmonary vascular density in controls, but enhanced both measures in Bmpr2EC-/- mice. Conclusion: Loss of BMPR2 results in a shift of the endothelial BMP9 response towards enhanced …
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Role of MDM2 In Cell Growth Regulation
… studies suggest that another inhibitory domain, ID2, inhibits DNA replication, while an MDM2 deletion mutant containing the N-terminal 1-220 amino acids including inhibitory domain ID1 does not effectively prevent BrdU incorporation in an immortal cell line that is non-responsive to growth arrest …
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Separate Roles of FAN1 and Fanconi Anemia Proteins in DNA Interstrand Crosslink Repair and Human Disease
… as a direct interacting partner of FANCI/FANCD2 (ID2) complex of the Fanconi anemia pathway. Using cells isolated from human KIN patients and Fan1-deficient mice, we showed that ICL repair function of FAN1 is non-overlapping with Fanconi anemia proteins, yet redundant with SNM1A, an exonuclease …
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Comprehensive Integrated Genomic and Histopathological Analysis of Paediatric Diffuse Intrinsic Pontine Glioma
… 2p with high-level amplifications of MYCN and ID2. The Silent subgroup affects younger children, has genomes with minimal genomic instability and fewer mutations. Histologically, DIPG represent a spectrum of grade II-IV disease with vast regional differences and frequent leptomeningeal …
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A comprehensive survey of somatic mutation landscapes in normal human cells
… signatures encompassing SBS1 and SBS5 or ID1 and ID2 are present to varying degrees across all tissue structures. While some mutational signatures, such as SBS4, SBS7, or SBS88, are associated with unique aetiologies, many signatures have unknown causes. Furthermore, two previously undiscovered …
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Identification of novel regulators of lymphocyte development and differentiation using CRISPR-Cas9 screens
… transcription factor reporter mice (including Id2, T-bet, Gata3 and RORγt mice) identified additional potential novel regulators of the ILC developmental network. The application of functional CRISPR-Cas9 screens in primary immune cells has successfully identified new regulators of lymphocyte …
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The control of Schwann cell myelination during development and after nerve injury
… other hand, transcription factors cJun, Pax3, Id2 and signalling pathways Notch and p38 mitogen activated protein (MAP) kinases (MAPK) have been identified as negative regulators of Schwann cell differentiation and myelin formation. Recently, the HMG transcription factor Sox2 was identified as …
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The ontogeny and function of intestinal dendritic cells
… of CD103+CD11b- cDC depends on the TFs Id2, IRF8 and BatF3, the TF requirements for CD103+CD11b+ were not known. Using a mouse model that selectively depletes the TF IRF4 selectively in CD11c+ cells, we show that, similar to splenic/lymph node CD11b+ cDCs, intestinal CD103+CD11b+ cDCs …
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Structural Analysis of Cylindrical Particles by Small Angle X-ray Scattering
… a Kratky-Compact-Camera in our laboratory or ID2 beamline of the European Synchrotron Radiation Facility (ESRF) in Grenoble. The synthetic clay particles, Laponite RD, have been chosen as ideal disc-shaped model particles. In combination of SAXS with static light scattering, the scattering …