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Showing 1 to 8 of 8 for “"IVIVC"”.
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IN VITRO IN VIVO METHODS AND PHARMACOKINETIC MODELS FOR SUBCUTANEOUSLY ADMINISTERED PEPTIDE DRUG PRODUCTS
… no established In vitro - In vivo correlation (IVIVC) for subcutaneously administered immediate release (IR) peptide based drugs in a biorelevant manner. The contribution of IVIVC in drug development of orally administered drugs is very well known. For oral drugs, the in vivo process of drug …
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Development of the Sustained Release Analgesic Formulations for Rodents and a Novel In Vitro Model for Parenteral Formulations with the Character of a Level A IVIVC
… of Level A In Vitro-In Vivo Correlation (IVIVC) and elaborate drug release mechanism. So far there is no successful in vitro dissolution method with the character of Level A IVIVC exists at present for parenteral oily formations. Only a few publications stated in vitro in vivo correction …
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Using an In Vitro-In Vivo Correlation for the ‘Bioequivalence by Design’ Development of an Immediate Release Carbamazepine Product
… based in vitro-in vivo correlation (PB-IVIVC) model that had been nested within a clinical trial simulation platform. The PB-IVIVC method provides a direct link from dissolution performance to clinical performance. Thus, when it is used to refine a CPP-vs-dissolution response surface, …
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BIORELEVANT RELEASE TESTING OF LONG-ACTING INJECTABLES INTENDED FOR PARENTERAL ADMINISTRATION
… profiles (in vitro-in vivo correlation (IVIVC)). However, the applicability of IVIVC models is limited when interactions of complex drug product (complex in the characteristics of the drug substance, the formulation and/or the route of administration) with the physiological environment …
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Sublingual drug delivery: In vitro-in vivo correlation
… on the established in vitro in vivo correlation (IVIVC) of sublingual absorption parameters across two systems. Predicted plasma concentration-time profiles of propranolol, verapamil, naproxen, atenolol and caffeine were found to be in good agreement with the experimental profile with the …
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A 'Biorelevant' Approach for Accelerated In Vitro Release and In Vitro-In Vivo Relationship of a Biodegradable, Naltrexone Implant
… Effects. A good In vitro-In vivo Correlation (IVIVC) resulted from both devices; however, the capillary device provided a superior simulation for the lag-time in absorption. The accelerated study at 45°C and 55°C established a predictable increase in release rates (2-fold and 4-fold increases, …
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The release of nicotine from chewing gum formulations
… used in vitro could be successfully used for IVIVC purposes, however statistically, chew rates of 10 and 20 chews per minute performed better than all other chew rates. Finally a series of nicotine gums was made to investigate the effect of formulation variables on release of nicotine from the …
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In vitro methods to predict aerosol drug deposition in normal adults
This research was aimed at the development and validation of new in vitro methods capable of predicting in vivo drug deposition from dry powder inhalers, DPIs, in lung-normal human adults. Three physical models of the mouth, throat and upper airways, MT-TB, were designed and validated using the …