Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"ITR"”.
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Conversion of equine umbilical cord matrix mesenchymal stem cells to the trophectoderm lineage using the Yamanaka reprogramming factors
… cells were termed equine induced trophoblast (iTr) cells. Culture of the iTr cell in suspension resulted in formation of blastocyst-like spheres rather than solid cell aggregates indicative of ES and iPS cells. The iTr cells were transitioned to a feeder free monolayer culture. Transformation …
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Insider trading: Regulation, securities markets and welfare
… question about insider trading regulation (ITR) is: Does ITR make society better off or worse off? In this dissertation, I evaluate the impact of ITR on a securities market and on social welfare, paying special attention to the welfare issue.
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Equine Trophectoderm Cells and Their Role in Fetal-Maternal Recognition
… A novel equine induced trophoblast cell line (iTr) that closely mimics the genotype and phenotype of native equine TE was created. Transcriptome analysis of iTr revealed increased expression of growth factor (GF) receptors for Epidermal GF (EGF), Hepatocyte GF (HGF), Fibroblast GF-2 (FGF-2) and …
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Causal Effect Random Forest Of Interaction Trees For Learning Individualized Treatment Regimes In Observational Studies: With Applications To Education Study Data
<p>Learning individualized treatment regimes (ITR) using observational data holds great interest in various fields, as treatment recommendations based on individual characteristics may improve individual treatment benefits with a reduced cost. It has long been observed that different individuals …
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A Non-Parametric Framework for Value-Based Individualized Treatment Rule Estimation
… often denoted as individualized treatment rules (ITRs). While optimal performance of an ITR is of great importance, interpretability of the treatment rule, an understanding of 'why' a treatment path is being recommended, is also of concern to patients. Despite a rich literature concerning ITR …
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PIECING TOGETHER THE PUZZLE OF TREATING HEMOPHILIA A UTILIZING AAV BASED GENE THERAPY
… cloning to generate plasmids containing only one ITR. Our work shows that plasmids containing only a single ITR can be packaged into virions during normal rAAV production. This is an issue as single ITR containing plasmids are found in plasmid preparations used for AAV production. These single ITR …
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An analysis of the current investment trend in the U.S. toll road sector
… Chicago Skyway and $3.85bn Indiana Toll Road (ITR) have been completed and a $12.8bn Pennsylvania Turnpike deal has just been accepted (There are numerous other much smaller existing toll road concessions in the US not covered in this paper). One interesting observation is that for the Skyway …
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Uso do EuroSCORE como preditor de morbidade no pós-operatório de cirurgia cardíaca
… cardíaca: infecção do trato respiratório (ITR), acidente vascular Cerebral (AVC) e insuficiência renal dialítica (IRD).Métodos: Foram analisados, retrospectivamente, os prontuários de 900 pacientes operados no Real Hospital Português do Recife e admitidos na unidade de terapia intensiva …
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Bond exchange reactions in high temperature thermoset polymers
… assembly. Interchain transesterification (ITR) is a type of bond exchange reaction accessible by polymers possessing ester bonds. Thermoset polymers that have a high density of exchangeable bonds are referred to in the literature as vitrimers. Vitrimers have enhanced processability via …
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Design of unique composites based on aromatic thermosetting copolyesters
… via the Interchain Transesterification Reaction (ITR). ITR can also be used for reduction in void volume and healing of microcracks. Thus, ATSP resin systems provide a unique intrinsic repair mechanism compared to any other thermosetting systems in use today. Preliminary studies on measurement of …
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Personalised warfarin dosing in children after congenital heart surgery using the model-based approach
… the INR observations within the target range (%ITR) was higher (70% vs 47.4%), the median percentage of time in therapeutic range (%TTR) was higher (83.4% vs 62.3%), the median frequency of INR measurements per month was comparable (5.0 vs 6.3) and the median frequency of dose alterations was …
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Contributions to statistical learning and its applications in personalized medicine
… the problem of Individualized Treatment Rule (ITR) and analyzes the solution of it through Discriminant Analysis. In the ITR problem, the treatment assignment is done based on the particular patient's prognosis covariates in order to maximizes some reward function. Data generated from a random …
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Investigating the Role of the IP₃ Signalling Pathway in RNA Interference in C. elegans
… shown that loss of function in the IP₃ receptor (ITR-1) or in PLCβ (EGL-8) results in an enhanced response to exogenous dsRNA, with a more robust silencing response than that seen in WT worms. Conversely the potentiation of IP₃ signalling by the loss of function IPP-5, a phosphatase which …
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Developing tailored approaches from multi-arm randomised trials with an application to blood donation
… the optimal individualised treatment rule (ITR) in multi-arm trials and comparing their performance in large-scale trials via simulation studies in Chapter 2. We also apply these methods to the data from male donors in the INTERVAL trial to estimate the optimal personalised donation …
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A supervised machine-learning method for detecting steady-state visually evoked potentials for use in brain computer interfaces: A comparative assessment
… used the more the Information transfer rate (ITR) decreases. Undertaking a successful classification on only the initial 250 ms portions of SSVEP data would lead to an improved ITR and a BCI which is faster to use. Classification of each method was assessed at three SSVEP window periods (0.25, …
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Development of aromatic polyesters for high performance applications and use of interchain transesterification reactions as a solid-state fabrication tool
… to 320°C that interchain transesterifications (ITR - a class of solid state chemical reactions available to aromatic polyesters) are responsible in part for low wear rates via ATSP reincorporating its own wear debris and development of a stable transfer film. Additionally, it is found that a …
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Development and Characterisation of a Radiation Hard Readout Chip for the LHCb-Experiment
… well as components of the digital control circuitry. An interface compatible with the I2C-standard and the control logic for event readout have been implemented. A scheme has been developed which ensures the robustness of the Beetle chip against Single Event Upset (SEU). This includes the …
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Expanding the genome editing toolbox for biomedical applications
… insertion of AAV’s inverted terminal repeat (ITR) sequences. Both of these bystander mutations were missed by standard genotyping. This highlights the need for more thorough validation and development of improved transgene delivery methods. Therefore, we further investigated alternative …
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Investigation into Stand-alone Brain-computer Interfaces for Musical Applications
… The obtained information transfer rate (ITR) is 36.56±9.17 bits min-1, which surpasses communication rates of earlier BCMIs. This thesis concludes by building a system which encompasses a novel control flow, which allows the user to play a musical instrument by gazing at it.
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Design of aromatic thermosetting polyester composites for thermally stable devices
… induced local orientation of ATSP is observed. ITR process is proved to be effective in repairing the cracks and scratches of composites. In addition, the first electrical property test is achieved on ATSP/glass fiber composite. The insertion loss is less than standard circuit board FR-4.
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