Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"ITIM"”.
-
Generierung von chimären Mäusen mit Mutationen in der Signalleitungs-Domäne von CD22 und Untersuchungen zur Funktion von CD22 in Knockout-Mäusen
… sich 6 konservierte Tyrosine, 3 davon in ITIMs (Immunrezeptor tyrosinhaltige inhibitorischen Motiven). Nach Kreuzvernetzung des B-Zell Rezeptors wird CD22 tyrosinphosphoryliert. Die cytosolische Tyrosin-Phosphatase SHP-1 bindet in der Folge an die phosphorylierten ITIMs, wird aktiviert, …
-
Investigating the novel interaction between hERG and the Fc region of IgG and its consequences
… immunoreceptor tyrosine-based inhibitory motif (ITIM) within the C-terminus of hERG is necessary for this internalization, with its substitution (Y827A) completely preventing this effect. Inhibition of both Src and Src homology region 2 domain-containing phosphatases (SHP) further mitigate IgG’s …
-
Mechanistic and Functional Characterization of B and T Lymphocyte Attenuator (Btla) In Cd8 Tumor Infiltrating Lymphocytes
… phenotype. While the suppressive function of the ITIM and ITSM motifs of BTLA are well described, the Grb2 motif’s function remains understudied.</p> <p>In this study, we sought to determine the functional characteristics of the CD8<sup>+</sup>BTLA<sup>+</sup>TIL subset and define the contribution …
-
Studies on the Leukocyte-Associated Ig-Like Inhibitory Receptor-1 Signaling Pathway in T Lymphocytes
… Immuno-receptor Tyrosine-based Inhibitory Motif (ITIM)-bearing receptors in immune cells, including T lymphocytes, play a major role in preventing autoimmune responses. Leukocyte-associated Ig-like Inhibitory Receptor 1 (LAIR-1) is one of ITIM-bearing receptors. The mechanism by which LAIR-1 …
-
Influence of Polyolefin Contamination on the Thermal Characteristics of Bottle Grade Recycled Polyethylene Terephthalate
During the mechanical recycling, especially during the sorting and separation process of bottle grade PET, cross contamination with polyolefin is inevitable. Very small number of polyolefin bottles, caps and closures pass through the separation process and get recycled with PET bottles and affect …
-
The impacts of psychological stress on innate-like invariant T cell survival, phenotype, and function
… T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) in a GR-dependent manner and blockade of TIGIT partially restores their functional capacity in stressed mice. Ultimately, in a GR-dependent fashion, iNKT cells from stressed mice fail to prevent pulmonary metastases of B16 …
-
Molecular Structure and Thermodynamics of CO<sub>2</sub> and Water Adsorption on Mica
… interfaces simultaneously. Using the ITIM (Identification of the Truly Interfacial Molecules) analysis, how individual water layers develops in this film as RH increases is delineated. It was discovered that the water film is spatially heterogeneous, and the true liquid-vapor interface …
-
Klonierung und Charakterisierung von Signal Regulatory Protein beta in primären Makrophagen der Maus
… Tyrosin Based Inhibition Motifs� (ITIM) trägt und damit zur Klasse der In-hibitorischen Rezeptoren gehört. Vertreter der SIRPb gehören zur Klasse der aktivierenden Rezeptoren, besitzen aber nur einen kurzen intracytoplasmatischen Teil. Zur Signaltransduk-tion assoziieren sie über …
-
Molekularbiologische und funktionelle Charakterisierung neuer "Chicken Ig-like" Rezeptoren
… by two exons, the last exon containing the ITIMs. The exon/intron boundaries conformed to the gt-ag rule and the exon phases were highly conserved. In conclusion, the genomic organisation showed conserved features of mammalian Ig-like receptor genes. The novel identified CHIR were grouped …
-
Study of Regulated Cell Death In Two Systems: Pd-1 In Natural Killer Cells and Rip3 In Neurons
… immunoreceptor tyrosine-based inhibitory motif (ITIM) of PD-1 was crucial for its inhibitory effect on cytotoxicity.</p> <p>In the second part, I examined the involvement of RIP3 in acidosis-induced cell death, which critically contributes to ischemic brain injury and was recently shown to occur …
-
On the role of treml6 in B-1a B cell development And ICOS co-stimulation in adaptive immune responses against M. tuberculosis
… TLT-6 (Gen: treml6), einem bislang unerforschten ITIM-tragenden Rezeptor der TREM Rezeptor Familie, mittels Analyse von treml6-WT und eigens generierten treml6-/- Mäusen. Treml6 mRNA wurde vornehmlich von Leukozyten der Peritonealhöhle und lymphoiden Organen exprimiert. Treml6-/- Mäuse waren …
-
Verwendung von Gene-Targeting-Techniken zur Etablierung neuer Mauslinien mit Mutationen in B-Zell-Signalwegen
… Phosphorylierungsstellen, von denen drei eine ITIM-Sequenz (engl. immunoreceptor tyrosine-based inhibitory motif) aufweisen. CD22 defiziente Mäuse zeigten eindeutig, daß das Siglec CD22 ein negativer Regulator des BCR-Signals ist. Durch BCR-Kreuzvernetzung wird CD22 tyrosinphosphoryliert, die …