Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"ISW2"”.
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THE MECHANISMS OF ISW1A, ISW1B AND ISW2 CHROMATIN REMODELERS
… it is a concerted effort of the C-terminus of Isw2 and the ATPase domain to mobilize the nucleosomal DNA.
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ROLES OF ACCESSORY DOMAINS IN THE CATALYTIC SUBUNIT OF ISW2
… ATP-dependent chromatin remodeler complexes. ISW2 belongs to the ISWI family of chromatin remodelers in Saccharomyces cerevisiae and has been shown to be involved in transcription repression and DNA replication. The catalytic subunit of ISW2 consists of the ATPase domain and three domains at …
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE ISW2 CHROMATIN REMODELING COMPLEX
… space nucleosomes to regulate gene expression. ISW2, an ISWI remodeler in yeast, has been shown to reposition nucleosome near promoter regions and represses both mRNA and antisense non coding RNA transcription. ISW2 is composed of four subunits and the catalytic Isw2 subunit consists of several …
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MECHANISMS OF CHROMATIN REMODELING BY ISWI FAMILY OF REMODELERS: A FUNCTIONAL AND STRUCTURAL INSIGHT INTO THE ROLE OF THE Itc1 SUBUNIT OF ISW2 REMODELING COMPLEX
… the movement of nucleosomes along DNA. In the ISW2 complex, the Itc1 (accessory) and Isw2 (catalytic) subunits make up the minimal active complex. ISW2 moves mononucleosomes to the center of DNA as a function of the length of extranucleosomal DNA. This same property is also responsible for the …
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THE UNIQUE STRUCTURE AND MECHANISM OF INO80 - AN ATP DEPENDENT REMODELER OF THE HISTONE EXCHANGER FAMILY
… binding as well as remodeling by INO80 much like ISW2 and ISW1a. INO80 preferentially binds to nucleosomes containing >20bp of extranucleosomal DNA. Similarly, INO80 remodeling of mononucleosomes with different lengths of extranucleosomal DNA showed that at least 33bp of extranucleosomal DNA on …
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DYNAMICS OF NUCLEOSOME REMODELING BY ATP-DEPENDENT CHROMATIN REMODELERS
… octamer dynamics on nucleosome remodeling by ISW2, mechanism of dimer exchange by INO80 and mechanism of nucleosome disassembly by the coordinated action of RSC and histone chaperone Nap1. We also provide insights on how aberrant SWI/SNF complexes affect fundamental enzymatic properties such …
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DISTINCT GENOME WIDE FUNCTIONS OF CHROMATIN REMODELERS IN NUCLEOSOME ORGANIZATION AND TRANSCRIPTION REGULATION
… All members of the ISWI family (ISW1a, ISW1b, ISW2) share a conserved C-terminal HAND, SANT and SLIDE domains, which are important for sensing linker DNA. We find an auto-regulation of ISWI complexes by the SLIDE domain, independent of the histone H4 Nterminal tail. Our protein-protein chemical …
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The Regulation and Evolution of long, noncoding RNA Transcription
… chromatin remodeling factors: Swr1, Isw2, Rsc, Ino80. I then use strand-specific, high-throughput RNA sequencing (ssRNAseq) to identify the lncRNA targets of these complexes. Further, I go on to show that these factors largely regulate distinct populations of lncRNAs genome-wide, that …
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SWI/SNF COMPLEXES COORDINATE WITH HISTONE MODIFICATIONS TO REGULATE CHROMATIN REMODELING
… DNA at one end of the nucleosome like ISW2 and also like SWI/SNF but only when recruited by transcription factors. DNA crosslinking revealed that most of the SWI/SNF contacts are with a small region spanning the DNA translocation start site near SHL2 and does not extend to the rest of …