Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"ISRIB"”.
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A MOLECULE-INHIBITOR OF THE INTEGRATED STRESS RESPONSE REGULATES ACTIVITY OF MAMMALIAN EUKARYOTIC TRANSLATION INITIATION FACTOR 2B
… matter. A new chemical inhibitor of the ISR (ISRIB), a bis-O-arylglycolamide, can reverse the attenuation of mRNA translation by phosphorylated eIF2 protecting mice from prion-induced neurodegeneration and traumatic brain injury. The work presented in this dissertation describes identification …
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Investigating coordination between stress-induced translational and transcriptional attenuation
… molecule inhibitor of the ISR, ISR inhibitor (ISRIB). ISRIB treatment has been shown to improve age-related cognitive decline in mice. ISRIB treatment is also neuroprotective in prion diseased mice. Although ISRIB has not been shown as a human therapeutic, the use of ISRIB in mouse models …