Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"ISGylation"”.
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ISG15 conjugation : cellular targets and the lysine selectivity of HERC5
… at the transcriptional level by type I IFN. ISGylation of pathogen and host proteins is a component of cellular defense against viruses. Consistent with this, many viruses have evolved mechanisms to counteract the effects of ISGylation. SARS-CoV-2, for example, encodes an ISG15-deconjugating …
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Evaluation of the role of autophagy in acute myeloid leukaemic cell differentiation
… protein handling - autophagy and ISGylation. Autophagy is an intracellular recycling pathway responsible for degrading aged or redundant proteins. I demonstrate that ATRA induces autophagy and this has a functional role in differentiation. Autophagy inhibition reduces myeloid …
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Disentangling bacterial virulence mechanisms: Klebsiella pneumoniae targets post-translational modifications (PTMs) to manipulate innate immunity
… in vivo and here it is shown Klebsiella targets ISGylation, a type I IFN-dependent PTM, in vitro. ISGylation is analogous to ubiquitylation and involves the reversible conjugation of the ubiquitin-like modifier (UBL), IFN-Stimulated Gene 15 (ISG15) to target substrates. Whilst a crucial component …
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The roles of papain-like protease-related proteins in viral replication and host immunity
… the PLP2 domain-mediated deubiquitination and deISGylation effects. The infection of nsp2TF/nsp2N knockout mutants significantly upregulated antiviral innate immune responses in vitro. Furthermore, manipulating the expression of nsp2TF/nsp2N could enhance innate and adaptive immunity in pigs, …
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Systems Biology of Host-Pathogen Protein-Protein Interactions
… immune signaling by targeting IFIT5 for de-isgylation. Although host interactome is indirectly affected during viral infection, earlier studies have only focused on characterizing the properties of the viral proteins within the host-viral interactions. However, systematically exploring the …