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Showing 1 to 17 of 17 for “"ISG15"”.
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ISG15 conjugation : cellular targets and the lysine selectivity of HERC5
ISG15 is a 17 kDa ubiquitin-like protein that functions in the innate immune response to pathogens. While human ISG15 is a multifunctional protein, its canonical function is that of an intracellular ubiquitin-like protein modifier. Like ISG15, the human E1 (UBE1L), E2 (UBE2L6) and E3 (HERC5) …
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A Role for Interferon Stimulated Gene-15 (ISG15) During Chikungunya Virus Infection
… Role for Interferon Stimulated Gene-15: ISG15) During Chikungunya Virus Infection</p><p>By</p><p>Scott William Werneke</p><p>Doctor of Philosophy in Biology and Biomedical Science</p><p>(Immunology)</p><p>Washington University in St. Louis, 2013</p><p>Professor Deborah J. Lenschow, …
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Species Preference of Viral Deubiquitinating Proteases Toward ISG15 Through Structural and Enzymatic Characterization
… molecules such as interferon stimulated gene 15 (ISG15), have been identified as a potential virulence factor through their role in evading the innate immune response. Study and characterization of vOTUs involves evaluating their activity and preferences for Ub, ISG15, as well as the variety of …
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The interaction between NS1B protein of influenza B virus and the ubiquitin-like modifier ISG15 : insights into a unique species specific property of the virus
… acids of NS1B bind a cellular protein called ISG15. ISG15 is an interferon induced 'ubiquitin-like' protein, and upon interferon induction, is conjugated to hundreds of targets. It has been found that both ISG15 and its conjugation inhibit many viruses. The focus of the current study was to …
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Elucidation of the roles of PTN and ISG15 in RSV cytopathogenesis: possible biomarkers of severe disease?
… of these genes, interferon‐stimulate gene 15 (isg15) and pleiotrophin (ptn), were of particular interest based on published work identifying the anti‐viral role of ISG15 in a number of viral illnesses and the established interaction of PTN with the recently identified RSV co‐receptor/entry …
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Disentangling bacterial virulence mechanisms: Klebsiella pneumoniae targets post-translational modifications (PTMs) to manipulate innate immunity
… modifier (UBL), IFN-Stimulated Gene 15 (ISG15) to target substrates. Whilst a crucial component of the host anti-viral response, the function of ISG15 and its associated PTM in the context of bacterial infection remains poorly understood. <br/><br/>Using an in vitro infection model, I …
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Biophysical Characterization of the vOTU Proteases from the CCHF and Dugbe Nairoviruses
… as the Ub-like interferon-stimulated gene 15 (ISG15). vOTU homologs have been found in numerous viruses across several families. Moreover, the effects of these viruses range in severity from mild flu-like symptoms to mortality depending on the species of the infected host. As such, several …
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Sindbisvirus aktivierte ISRE-bindende Komplexe in L-929- Zellen
… der ein humanes Interferon-stimuliertes Gen 15 ( ISG15 ) Verwendung fand, wiesen wir in Extrakten von sindbisinfizierten L-929 Zellen verschiedene Proteinkomplexe nach, die nicht in Extrakten uninfizierter Zellen nachweisbar waren. Übereinstimmung im Laufverhalten mit Extrakten NDV-infizierter …
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ISRE-bindende Komplexe nach Sindbisinfektion in Mäuse- und Hühnerzellen
… der ein humanes Interferon-stimuliertes Gen 15 ( ISG15 ) Verwendung fand, wiesen wir in Extrakten von sindbisinfizierten L-929 Zellen verschiedene Proteinkomplexe nach, die nicht in Extrakten uninfizierter Zellen nachweisbar waren. Übereinstimmung im Laufverhalten mit Extrakten NDV-infizierter …
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An Imaging Approach to Examine Telomere Dynamics and Regulation of Gene Expression with Aging
… for which TPE-OLD has been described before, ISG15 (Interferon Stimulated Gene 15) and TERT (TElomerase Reverse Transcriptase). For both genes I found less interaction with the telomere on the same chromosome in old cells compared to young cells. Experimentally elongated telomeres in old cells …
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Structural and functional studies of the papain-like protease 2 from mouse hepatitis virus
… as the substrate) and deISGylating activities (ISG15-AMC as the substrate). With the three substrates tested, MHV PLP2 can only be saturated by Ub-AMC with Km of 1.3 mM, but not by RLRGG-AMC or ISG15-AMC where Km is not determinable. This suggests that PLP2 has a higher binding affinity to Ub …
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Evaluation of the role of autophagy in acute myeloid leukaemic cell differentiation
… modifier, interferonstimulated gene 15 (ISG15) to target proteins. Targeted inhibition of ISGylation impedes differentiation. I discuss the benefits and practical implications of pharmacologically targeting both autophagy and ISGylation. A thorough molecular understanding of these …
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Cooperative Tumor Suppression by ARF and p53
<p>Cancer is a complex genetic disease characterized by the inactivation of tumor suppressor genes and enhanced activity of oncogenes leading to deregulated cellular proliferation. Two tumor suppressor genes, p53 and Arf, play important roles in protecting cells against numerous biological …
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Multifunctional Coronavirus Papain-Like Proteases as Targets for Antiviral Therapeutics and Vaccines
<p>Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and Middle Ease Respiratory Syndrome coronavirus (MERS-CoV) pose a severe threat to humans because of high mortality. Despite the risk of coronavirus (CoV) emerging in the human population there are no antiviral drugs or vaccines to combat …
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Genetic Variations in Interferon-Induced Genes and HCV Recurrence after Liver Transplantation
Hepatitis C Virus (HCV) infection represents a worldwide pandemic and is currently the leading cause of cirrhosis and liver transplantation. After transplantation recurrence is almost universal with 96% of patients testing positive for viral RNA and exhibiting histological evidence of infection …
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Determining the role of nerve growth factor-beta in seminal plasma on bovine reproduction
… expression of interferon-stimulated genes Isg15 and Mx2 at day 19 were greater in pregnant NGF cows than in pregnant CONT cows. Consistently, plasma pregnancy-specific protein B concentrations at day 24 were greater in pregnant NGF than in pregnant CONT cows, and fetal crown rump length …